scholarly journals Oral Liquid L-Thyroxine (L-T4) May Be Better Absorbed in Comparison to L-T4 Tablets in Patients With Lactose Intolerance

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A832-A832
Author(s):  
Poupak Fallahi ◽  
Silvia Martina Ferrari ◽  
Giusy Elia ◽  
Francesca Ragusa ◽  
Sabrina Rosaria Paparo ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Coeliac Disease ◽  
Atrophic Gastritis ◽  
Lactose Intolerance ◽  
Liquid Formulation ◽  
Oral Liquid ◽  
Tsh Levels

Abstract In patients with lactose intolerance (LI), L-thyroxine (L-T4) malabsorption is often present, that leads to the necessity to use elevated L-T4 doses in the substitutional treatment of hypothyroidism. After excluding non-compliance, the differential diagnosis should include such disorders as LI, atrophic gastritis, coeliac disease, and others. In case of a diagnosis of LI, a low lactose diet and a lactose-free L-T4 preparation should be administered, to decrease the dose of the L-T4 formulation, and restore euthyroidism. We report the normalisation of circulating thyrotropin (TSH) levels in 8 patients with LI who received L-T4 tablets, after switching to an oral liquid lactose-free formulation. After switching from oral tablets to the liquid L-T4 (at the same dose, 30 minutes before breakfast) TSH was significantly reduced (TSH, evaluated 1-3 months after the switch, decreased: from 7.5±3.1 to 3.2±2.4 μIU/mL, P<0.05). The return back to tablets (at the same dosage, 30 minutes before breakfast) caused thyrotropin levels to worsen again. This result leads us to believe that the absorption of oral liquid formulation of thyroxine is greater in these patients. In conclusion, these data suggest that the L-T4 oral liquid formulation could bypass the issue of malabsorption in patients with lactose intolerance.

scholarly journals Serum TSH Levels Normalisation in Patients Affected by Autoimmune Atrophic Gastritis, After the Switch From Oral L-T4 in Tablet Form to L-T4 in Liquid Formulation

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A833-A833
Author(s):  
Poupak Fallahi ◽  
Silvia Martina Ferrari ◽  
Giusy Elia ◽  
Francesca Ragusa ◽  
Sabrina Rosaria Paparo ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Dietary Habits ◽  
Patient Adherence ◽  
High Serum ◽  
Tablet Formulation ◽  
Liquid Formulation ◽  
Oral Liquid ◽  
Autoimmune Atrophic Gastritis ◽  
To Receive ◽  
Tsh Levels

Abstract Patients affected by autoimmune atrophic gastritis could have some issues in L-thyroxine (L-T4) absorption, due to drug malabsorption, induced by the increased gastric pH. Different factors influence L-T4 absorption, such as dietary habits, interference with other drugs, absorption kinetics, age of the patient, adherence to therapy, and others. We enrolled 36 patients affected by autoimmune atrophic gastritis with high serum thyrotropin (TSH) levels under therapy with L-T4 in the tablet formulation. L-T4 tablets were changed to an oral liquid L-T4 preparation, maintaining the same dose. The switch from L-T4 in tablet formulation to the liquid one, at the same L-T4 dosage, led to the normalisation/reduction of circulating TSH levels. Then 14 patients, who were switched back again to receive L-T4 in tablets (with the same dose), had a worsening of TSH values, falling in the hypothyroid range. In conclusion, our findings led to hypothesize that the pH alteration issue caused by autoimmune atrophic gastritis could be overcome by the oral L-T4 liquid formulation administration.

Irritable bowel syndrome and lactose intolerance: the importance of differential diagnosis. A monocentric study

2021 ◽  
Vol 67 (1) ◽  
Author(s):  
Roberto CATANZARO ◽  
Morena SCIUTO ◽  
Birbal SINGH ◽  
Surajit PATHAK ◽  
Francesco MAROTTA
Keyword(s):  
Irritable Bowel Syndrome ◽  
Differential Diagnosis ◽  
Lactose Intolerance ◽  
Irritable Bowel

THE STABILITY OF AN ORAL LIQUID FORMULATION OF CYSTEAMINE

1981 ◽  
Vol 6 (1) ◽  
pp. 67-70 ◽  
Author(s):  
A. Brodrick ◽  
Helen M. Broughton ◽  
Rosemary M. Oakley
Keyword(s):  
Liquid Formulation ◽  
Oral Liquid ◽  
The Stability

Development of an extemporaneous oral liquid formulation of oxandrolone and its stability evaluation

Burns ◽  
2011 ◽  
Vol 37 (7) ◽  
pp. 1150-1153 ◽  
Author(s):  
Alka Garg ◽  
Sanjay Garg ◽  
Richard Wong She
Keyword(s):  
Stability Evaluation ◽  
Liquid Formulation ◽  
Oral Liquid

Comparison of TSH Levels with Liquid Formulation Versus Tablet Formulations of Levothyroxine in the Treatment of Adult Hypothyroidism

2014 ◽  
Vol 20 (7) ◽  
pp. 657-662 ◽  
Author(s):  
Davide Brancato ◽  
Alessandro Scorsone ◽  
Gabriella Saura ◽  
Lidia Ferrara ◽  
Anna Di Noto ◽  
...  
Keyword(s):  
Liquid Formulation ◽  
Tablet Formulations ◽  
Tsh Levels

Studies on Malabsorption in Malnourished Pakistani Children

1988 ◽  
Vol 43 (9-10) ◽  
pp. 782-786 ◽  
Author(s):  
I. Mazahir ◽  
M. Ataur Rahman ◽  
M. A. Arif
Keyword(s):  
Coeliac Disease ◽  
Lactose Intolerance ◽  
Protein Energy Malnutrition ◽  
Amino Nitrogen ◽  
Common Finding ◽  
Control Group ◽  
Clinical Impression ◽  
Fibrocystic Disease ◽  
Control Subjects ◽  
Lactose Tolerance

Abstract Malnutrition is a common finding in Pakistan especially in children of low socio-economic class. Impairment of digestion and absorption makes the diet inefficient at fulfilling the requirements of the child and leads to malnutrition. Earlier work from this laboratory has shown that feeding a high-protein diet to children suffering from protein-energy malnutrition (PEM) did not improve their condition. In the present study forty-two malnourished children and seventeen control subjects were investigated. They were divided into five groups, i.e. fibrocystic disease of the pancreas (n = 9), coeliac disease (n = 17), lactose intolerance (n = 5), PEM (n = 5) and nonspecific diarrhoea (n = 6) on the basis of history, clinical impression and biochemical findings. They were from 6 months to 12 years of age. The majority of them were suffering from diarrhoea, distension of the abdomen and retardation of growth. All children were physically examined and anthropometric measurements were recorded. Changes in hair in the form of sparseness, dyspigmentation and easy pluckability were observed in all groups. In PEM, 80% of the cases had enlarged livers. All children had reduced weight and height as compared with the control group. Haemoglobin, total protein and serum albumin showed a decrease and the fall was greatest in PEM cases as compared with the control group. The excretion of a-amino nitrogen increased in PEM children while hydroxyproline and creatinine levels showed a decrease as compared with the control group. The hydroxyproline index, which signifies the growth rate, was also significantly lower in all groups. Xylose and lactose tolerance tests were performed after an oral dose of xylose or lactose respectively. The xylose concentration after the test dose was reduced with the lowest values in the coeliac disease group as compared with the control group. In the lactose tolerance test, the patients with lactose intolerance showed lower values as compared with control subjects. Sodium and chloride in sweat showed a significant rise in fibrocystic disease while daily faecal fat excretion was increased in fibrocystic disease, coeliac disease and lactose intolerance cases as compared with the control group. The various biochemical indicies studied indicate that malabsorption played an important role in malnourishment.

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