scholarly journals SUN-121 Vitamin D Repletion and Sitagliptin Administration is Associated with an Increase in Serum C-Peptide and a Decrease in GAD-65 Antibody and Hemoglobin A1c in a Patient with Latent Autoimmune Diabetes of Adults

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Nicholette Fox ◽  
Heidi Peynado De Pena ◽  
Gul Bahtiyar ◽  
Alan Sacerdote
Keyword(s):  
Vitamin D ◽  
Hemoglobin A1c ◽  
Autoimmune Diabetes ◽  
C Peptide ◽  
Latent Autoimmune Diabetes ◽  
Gad 65

Latent Autoimmune Diabetes in Adults (LADA) with High Titers of GAD 65 Antibodies but Lack of Long-Term Insulin Dependence.

2010 ◽  
pp. P3-560-P3-560
Author(s):  
Stefan Cadag ◽  
Ronak Patel ◽  
Jonathan Kahan ◽  
Emilia Pauline Liao ◽  
Leonid Poretsky
Keyword(s):  
Autoimmune Diabetes ◽  
Latent Autoimmune Diabetes ◽  
Insulin Dependence ◽  
Gad 65 ◽  
Gad 65 Antibodies

Vitamin D intake associates with insulin resistance in type 2 diabetes, but not in latent autoimmune diabetes in adults

2015 ◽  
Vol 35 (8) ◽  
pp. 689-699 ◽  
Author(s):  
Laura Ivonne Cardoso-Sánchez ◽  
Rita A. Gómez-Díaz ◽  
Niels H. Wacher
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Autoimmune Diabetes ◽  
Vitamin D Intake ◽  
Latent Autoimmune Diabetes

Identifying latent autoimmune diabetes in adults in Korea: The role of C-peptide and metabolic syndrome

2009 ◽  
Vol 83 (2) ◽  
pp. e62-e65 ◽  
Author(s):  
Seung-Hwan Lee ◽  
Hyuk-Sang Kwon ◽  
Soon-Jib Yoo ◽  
Yu-Bai Ahn ◽  
Kun-Ho Yoon ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Autoimmune Diabetes ◽  
C Peptide ◽  
Latent Autoimmune Diabetes

scholarly journals Urinary C-Peptide Creatinine Ratio as a Non-Invasive Tool for Identifying Latent Autoimmune Diabetes in Adults (LADA)

2019 ◽  
Vol Volume 12 ◽  
pp. 2531-2537 ◽  
Author(s):  
Wei Liu ◽  
Xingquan Huang ◽  
Xiuying Zhang ◽  
Xiaoling Cai ◽  
Xueyao Han ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Creatinine Ratio ◽  
C Peptide ◽  
Non Invasive ◽  
Latent Autoimmune Diabetes

scholarly journals Combined treatment with sitagliptin and vitamin D in a patient with latent autoimmune diabetes in adults

2016 ◽  
Vol 2016 ◽  
Author(s):  
E Rapti ◽  
S Karras ◽  
M Grammatiki ◽  
A Mousiolis ◽  
X Tsekmekidou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Autoimmune Diabetes ◽  
Combined Treatment ◽  
Acid Decarboxylase ◽  
Latent Autoimmune Diabetes ◽  
Glutamic Acid Decarboxylase Antibodies

Summary Latent autoimmune diabetes in adults (LADA) is a relatively new type of diabetes with a clinical phenotype of type 2 diabetes (T2D) and an immunological milieu characterized by high titers of islet autoantibodies, resembling the immunological profile of type 1 diabetes (T1D). Herein, we report a case of a young male, diagnosed with LADA based on both clinical presentation and positive anti-glutamic acid decarboxylase antibodies (GAD-abs), which were normalized after combined treatment with a dipeptidyl peptidase-4 inhibitor (DPP-4) (sitagliptin) and cholecalciferol. Learning points Anti-glutamic acid decarboxylase antibodies (GAD-abs) titers in young patients being previously diagnosed as type 2 diabetes (T2D) may help establish the diagnosis of latent autoimmune diabetes in adults (LADA). Sitagliptin administration in patients with LADA might prolong the insulin-free period. Vitamin D administration in patients with LADA might have a protective effect on the progression of the disease.

Saxagliptin improves glycaemic control and C-peptide secretion in latent autoimmune diabetes in adults (LADA)

2015 ◽  
Vol 32 (3) ◽  
pp. 289-296 ◽  
Author(s):  
R. Buzzetti ◽  
P. Pozzilli ◽  
R. Frederich ◽  
N. Iqbal ◽  
B. Hirshberg
Keyword(s):  
Glycaemic Control ◽  
Autoimmune Diabetes ◽  
C Peptide ◽  
Latent Autoimmune Diabetes ◽  
Peptide Secretion

scholarly journals C-Peptide compound analysis in type 2 diabetic patients

2019 ◽  
Vol 9 (3) ◽  
pp. 26-29
Author(s):  
Sagar R ◽  
Chandrudu J ◽  
Madhubhushan M ◽  
Seshaiah S
Keyword(s):  
Autoimmune Diabetes ◽  
Postprandial Blood Glucose ◽  
Diabetic Patients ◽  
Peptide Analysis ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Latent Autoimmune Diabetes ◽  
Blood Glucose Test ◽  
Type 2 Diabetic

In adults, a fragment of diabetic individuals with βcell autoantibodies has initially non Insulin requiring diabetes clinically performing as type 2 diabetes mellitus (T2DM), named latent autoimmune diabetes in maturity (LADA) which on later years requires Insulin. LADA is either unnoticed or misdiagnosed in many cases. The occurrence GAD autoantibodies and positive levels of C-peptide analysis are tested to determine and finalize the patients’ Insulin dependency. The frequency of βcell autoantibodies (GAD) and C-Peptide analysis was determined in 31 Type 2 diabetic adults. The type of diabetes was classified by doing a Postprandial Blood Glucose test. Ten Type 1 diabetic patients and 10 ordinary people were also subjected to the three tests for comparative study. Twenty-three per cent of the adults with T2DM were tested positive for GAD autoantibody, and 61 per cent were tested positive (who came in T1DM range) for C-peptide analysis among them. 19% of the patients were tested positive for both GAD antibody and C-peptide analysis. Patients had the common symptoms of polyuria, polyphagia and polydipsia. In T2DM patients, 61% were females, and 39% were males, and all were non-obese. β‐cell autoantibodies were evident in a subcategory of initially non‐insulin needy diabetic adults with the clinical entrance of T2DM. This proves the existence and necessity for change in Insulin dependency.

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