scholarly journals Risk factors for possible REM sleep behavior disorders

Neurology ◽  
2020 ◽  
Vol 95 (16) ◽  
pp. e2214-e2224
Author(s):  
Hui Zhang ◽  
Zhuqin Gu ◽  
Chun Yao ◽  
Yanning Cai ◽  
Yuan Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Rem Sleep ◽  
Positive Family History ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Multivariable Logistic Regression Analysis ◽  
Co Poisoning ◽  
Sleep Behavior ◽  
History Of

ObjectiveTo explore the risk factors for idiopathic REM sleep behavior disorder (RBD) in a community population in Beijing.MethodsParticipants aged 55 years and above were recruited from the Beijing Longitudinal Study on Aging II cohort. We identified individuals with possible RBD (pRBD) using the validated RBD Questionnaire–Hong Kong in 2010. A series of environmental, lifestyle, and other potential risk factors were assessed via standardized questionnaires in 2009. Multivariable logistic regression analysis was performed to investigate the association between the studied factors and pRBD.ResultsOf 7,225 participants who were free of parkinsonism and dementia, 219 (3.0%) individuals were considered as having pRBD. Participants with pRBD reported more nonmotor and motor symptoms of Parkinson disease (PD) with adjusted odds ratios (ORs) ranging from 1.10 to 4.40. Participants with pRBD were more likely to report a family history of parkinsonism or dementia (OR 3.03, 95% confidence interval [CI] 1.23–7.46). There was a significant association between pRBD and self-reported hyperlipidemia (OR 1.51, 95% CI 1.09–2.10), ever smoking (OR 1.79, 95% CI 1.20–2.65), prior carbon monoxide (CO) poisoning (OR 2.30, 95% CI 1.39–3.83), and nonoccupational exposure to pesticides (OR 2.21, 95% CI 1.40–3.50).ConclusionOur study replicated previously reported associations between pRBD and hyperlipidemia, smoking, pesticide exposure, and several prodromal PD symptoms. We also found previously unreported links with a positive family history of parkinsonism or dementia and CO poisoning. Risk factor profiles for pRBD partially resemble those defined for PD, but also differ in distinct ways.

Cardiovascular Risk Factors and Phenoconversion to Neurodegenerative Synucleinopathies in Idiopathic REM Sleep Behavior Disorder

2022 ◽  
pp. 1-7
Author(s):  
Sheida Zolfaghari ◽  
Natalia Lewandowski ◽  
Amelie Pelletier ◽  
Seyed Ali Naeimi ◽  
Jean-François Gagnon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rem Sleep ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Metabolic Risk ◽  
Sleep Behavior ◽  
History Of ◽  
Atherosclerotic Risk Factors

Several studies have suggested that atherosclerotic diseases and diabetes may be risk factors for α-synucleinopathies. This prospective cohort study evaluated whether cardiovascular diseases and metabolic risk factors alter the rate or type of phenoconversion from idiopathic/isolated REM sleep behavior disorder (iRBD) to parkinsonism or dementia. Polysomnography-confirmed iRBD patients recruited between 2004 and 2020 were followed annually. Baseline history of cardiovascular disorders, hypertension, hypercholesterolemia, and diabetes were compared among patients who developed outcomes versus those who remained outcome-free. No atherosclerotic risk factors were associated with development of α-synucleinopathies. Patients with hypercholesterolemia were somewhat more likely to develop dementia with Lewy bodies rather than Parkinson’s disease.

scholarly journals P1-324: APOE ε4 AND REM SLEEP BEHAVIOR DISORDER AS RISK FACTORS FOR SUNDOWN SYNDROME IN ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P368-P368
Author(s):  
Jung Min Pyun ◽  
Min Ju Kang ◽  
Jeewon Suh ◽  
Moon-ku Han ◽  
Young Ho Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Apoe Ε4

Sertraline Associated with REM Sleep Behavior Disorder: A Case Report

2019 ◽  
Vol 8 (2) ◽  
pp. 159-162 ◽  
Author(s):  
Seyed Mostafa Mansouripour ◽  
Dharmendra Kumar
Keyword(s):  
Case Report ◽  
Rem Sleep ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Motor Behavior ◽  
Antidepressant Medication ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Cord Injury ◽  
History Of

Background: REM sleep behavior disorder (RBD) is manifested by abnormal motor behavior with an endurance of tone during REM sleep. Studies suggest that patients taking Selective serotonin reuptake inhibitors (SSRIs) are at greater risk of developing REM sleep behavior disorder. Case Presentation: We present a case of 39-year-old female with a past medical history of spinal cord injury from a gunshot wound 19 years ago resulting in paraplegia, posttraumatic stress disorder(PTSD), chronic pain, and chronic sleep problem. After sertraline started and up-titrated to 200 mg for her anxiety, she noticed worsening of her nighttime sleep behavior. Her mother also witnessed sleepwalking episode and doing things which the patient had no recollection in the morning, including trying to take a bath and eat from the refrigerator. On her follow-up appointment, her sertraline was discontinued altogether and she was started on Escitalopram 5 mg. She tolerated the medication well, it helped moderately with her anxiety and by the time of this case report (approximately 1 month) patient did not report any sleep-related behavior. Conclusion: Since antidepressant medication is very commonly prescribed, it is important to be cautious of physiologic changes they may induce, even if the clinical significance of these changes is not fully elucidated. In addition, RBD may predict neurodegenerative disorders a couple of years earlier, so it may be used as an effective early marker of neurodegenerative diseases.

Hiding in plain sight: Risk factors for REM sleep behavior disorder

Neurology ◽  
2012 ◽  
Vol 79 (5) ◽  
pp. 402-403 ◽  
Author(s):  
S. S. Sullivan ◽  
C. H. Schenck ◽  
C. Guilleminault
Keyword(s):  
Risk Factors ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

APOE ɛ4 and REM Sleep Behavior Disorder as Risk Factors for Sundown Syndrome in Alzheimer’s Disease

2019 ◽  
Vol 69 (2) ◽  
pp. 521-528 ◽  
Author(s):  
Jung-Min Pyun ◽  
Min Ju Kang ◽  
Younghwa Yun ◽  
Young Ho Park ◽  
SangYun Kim
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

scholarly journals Risk factors for probable REM sleep behavior disorder

Neurology ◽  
2016 ◽  
Vol 86 (14) ◽  
pp. 1306-1312 ◽  
Author(s):  
Janice C. Wong ◽  
Junjuan Li ◽  
Milena Pavlova ◽  
Shuohua Chen ◽  
Aiping Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior
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