Prediksi Pencapaian Target Peserta Keluarga Berencana Pasca Persalinan Menggunakan Algoritma Backpropagation

Population growth in Indonesia continues to increase, so the government makes a program to control the rate of growth of the population, namely the Family Planning Program (KB). The implementation of family planning also has another objective, namely to reduce the risk of maternal death after childbirth. To measure the level of increasing target achievement of postpartum family planning participants. So that it can be a reference for the DPPKBP3A in carrying out the postpartum family planning program. Data from the Population Control, Family Planning, Women Empowerment and Child Protection (DPPKBP3A) District Lima Puluh Kota data processed in this study is data on the achievement of postpartum family planning participants from 2018 to 2020. Data processing uses the Backpropagation algorithm through several stages, namely the stage initialization, activation stage, weight training (weight change) and iteration stage. One of the results obtained from the calculation is the comparison of the target with the output gradient error in Suliki District in 2018, namely the target of 0.11311 and the result of the error gradient output is -0.1171. The prediction results obtained from this process become a reference for the Population Control, Family Planning and Women Empowerment and Child Protection Agency (DPPKBP3A) of District Lima Puluh Kota to implement the implementation of postpartum family planning programs to the community the following year.

1411Alcohol and tobacco use and risk of multiple myeloma: a case-control study

Background Although responsible for significant mortality and morbidity, our knowledge of modifiable causes of multiple myeloma (MM) remains limited. This analysis of an Australian population-based case-control family study investigated associations between smoking and alcohol consumption and MM risk. Methods Incident cases (n = 789) of MM were recruited mainly via cancer registries in Victoria and NSW. The controls included in the analysis (n = 1,113) were either family members of cases (n = 696) or recruited as part of a similarly designed case-control family study of renal cancer (n = 417). Unconditional multivariable logistic regression was used to estimate ORs, 95% CIs and p-values for associations between alcohol- and tobacco-related exposures and risk of MM. Results Heavy drinkers of alcohol had lower MM risk compared with non-drinkers (OR = 0.68, 95% CI = 0.50 – 0.93), and there was an inverse dose-response relationship for alcohol intake (OR per 10g ethanol per day = 0.92, 95% CI: 0.86 – 0.99); there was no evidence of interaction with sex (p = 0.27). There was no evidence of association between smoking-related exposures and MM risk. Conclusions These findings extend the knowledge of MM risk factor epidemiology. Further research into the causality of the association of alcohol with MM risk and potential underlying mechanisms is recommended. Key messages We found alcohol consumption to be inversely associated with risk of multiple myeloma.

Prediksi Pencapaian Target Peserta Keluarga Berencana Pasca Persalinan menggunakan Algoritma Backpropagation

Population growth in Indonesia continues to increase, so the government makes a program to control the rate of growth of the population, namely the Family Planning Program (KB). The implementation of family planning also has another objective, namely to reduce the risk of maternal death after childbirth. To measure the level of increasing target achievement of postpartum family planning participants. So that it can be a reference for the DPPKBP3A in carrying out the postpartum family planning program. Data from the Population Control, Family Planning, Women Empowerment and Child Protection (DPPKBP3A) District Lima Puluh Kota data processed in this study is data on the achievement of postpartum family planning participants from 2018 to 2020. Data processing uses the Backpropagation algorithm through several stages, namely the stage initialization, activation stage, weight training (weight change) and iteration stage. One of the results obtained from the calculation is the comparison of the target with the output gradient error in Suliki District in 2018, namely the target of 0.11311 and the result of the error gradient output is -0.1171. The prediction results obtained from this process become a reference for the Population Control, Family Planning and Women Empowerment and Child Protection Agency (DPPKBP3A) of District Lima Puluh Kota to implement the implementation of postpartum family planning programs to the community the following year.

Population-based estimates of the age-specific cumulative risk of breast cancer for pathogenic variants in CHEK2: Findings from the Australian Breast Cancer Family Registry.

551 Background: Case-control studies of breast cancer have consistently shown that pathogenic variants in CHEK2 are associated with about a 3-fold increased risk of breast cancer. Information about the recurrent protein truncating variant CHEK2c.1100delC dominates this estimate. There have been no formal estimates of age-specific cumulative risk of breast cancer for all CHEK2 pathogenic (including likely pathogenic) variants combined. Methods: We conducted a genetic screen of CHEK2 in an Australian population-based case-control-family study of breast cancer. This study is focused on disease at an early age and participants were unselected for family history. The age-specific cumulative risk (penetrance) of breast cancer was estimated using segregation analysis. Results: The estimated hazard ratio for carriers of pathogenic CHEK2 variants (combined) was 4.9 (95% CI 2.5-9.5; p < 0.0001) relative to non-carriers. The HR for carriers of the CHEK2 c.1100delC variant was estimated to be 3.5 (95% CI 1.02-11.6) and the HR for carriers of all other CHEK2 variants combined was estimated to be 5.7 (95% CI 2.5-12.9). The age-specific cumulative risk of breast cancer was estimated to be 18% (95% CI 11-30%) and 33% (95% CI 21-48%) to age 60 and 80 years, respectively. Conclusions: These findings provide important information for the clinical management of breast cancer risk for women carrying pathogenic variants in CHEK2.

A Dynamic Framework of Noneconomic Goals and Inter-Family Agency Complexities in Multi-Family Firms

Multi-family firms represent an important and complex type of family firm that is not as well understood as single-family firms. We develop a governance-based framework of the agency complexities in multi-family firms, theorizing that divergent family-centered noneconomic goals between the owning families create complex inter-family agency problems that are intensified by evolving family dynamics. We propose governance mechanisms that address these problems by limiting opportunistic behavior associated with the pursuit of noneconomic goals related to firm control, family altruism, social capital, and transgenerational succession. We then present a future research agenda that can expand our knowledge of multi-family firms.

Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in CHEK2: Findings from the Australian Breast Cancer Family Registry

Case-control studies of breast cancer have consistently shown that pathogenic variants in CHEK2 are associated with about a 3-fold increased risk of breast cancer. Information about the recurrent protein-truncating variant CHEK2 c.1100delC dominates this estimate. There have been no formal estimates of age-specific cumulative risk of breast cancer for all CHEK2 pathogenic (including likely pathogenic) variants combined. We conducted a population-based case-control-family study of pathogenic CHEK2 variants (26 families, 1071 relatives) and estimated the age-specific cumulative risk of breast cancer using segregation analysis. The estimated hazard ratio for carriers of pathogenic CHEK2 variants (combined) was 4.9 (95% CI 2.5–9.5) relative to non-carriers. The HR for carriers of the CHEK2 c.1100delC variant was estimated to be 3.5 (95% CI 1.02–11.6) and the HR for carriers of all other CHEK2 variants combined was estimated to be 5.7 (95% CI 2.5–12.9). The age-specific cumulative risk of breast cancer was estimated to be 18% (95% CI 11–30%) and 33% (95% CI 21–48%) to age 60 and 80 years, respectively. These findings provide important information for the clinical management of breast cancer risk for women carrying pathogenic variants in CHEK2.

A Novel Biallelic STING1 Gene Variant Causing SAVI in Two Siblings

STING-associated vasculopathy of infantile-onset (SAVI) is one of the newly identified types of interferonopathies. SAVI is caused by heterozygous gain-of-function mutations in the STING1. We herein report for the first time a homozygous variant in the STING1 gene in two siblings that resulted in constitutive activation of STING gene and the SAVI phenotype. Exome sequencing revealed a novel homozygous NM_198282.3: c.841C&gt;T; p.(Arg281Trp) variant in exon 7 of the STING1 gene. The variant segregated in the family to be homozygous in all affected and either heterozygous or wild type in all healthy. Computational structural analysis of the mutants revealed changes in the STING protein structure/function. Elevated serum beta-interferon levels were observed in the patients compared to the control family members. Treatment with Janus kinase inhibitor (JAK-I) Ruxolitinib suppressed the inflammatory process, decreased beta-interferon levels, and stopped the progression of the disease.

DETERMINANT ANALYSIS OF ENTREPRENEURIAL INTENTION AMONG MILLENNIAL IN YOGYAKARTA, INDONESIA

This study aims to analyze the determinant of millennial entrepreneurial intention in Yogyakarta. The subject in this study was the people resident in Yogyakarta with the age of 19 to 39 years old. Respondents were selected using a purposive sampling method. The data were gathered using questionnaires and analyzed by using multiple linear regression analysis. The finding of this study shows that overall the attitude, perceived behavioral control, family background, entrepreneurial knowledge, and social media have a positive and significant impact on entrepreneurial intention simultaneously. Whereas separately the results show that attitude, behavioral control, family background, and social media have a positive and significant impact on entrepreneurial intention while entrepreneurial knowledge has a negative and insignificant of the millennial generation in Yogyakarta. Overall, this research provides some crucial insights for Yogyakarta’s local government to highlight possible steps for policy makers as a reference for entrepreneurship development.

On the sliding mode control for precision machining

Precision machining uses linear motor actuators in order to deal with robustness and stability in the broad range of cutting conditions. Those systems are demanding more sophisticated control algorithms in order to fulfil each time more exigent tolerances in the tendency to miniaturization of products and to face more robust dynamics. Sliding mode control family is natural approach to cope with mass and damping variation and external disturbances which are inherent characteristics of cutting processes. This paper compares conventional and super-twisting sliding mode controls on keeping the closed loop dynamics within requirements and reject disturbances created by the cutting forces.