High-frequency stimulation of the globus pallidus for the treatment of Parkinson's disease

Neurology ◽  
1997 ◽  
Vol 49 (1) ◽  
pp. 249-253 ◽  
Author(s):  
R. Pahwa ◽  
S. Wilkinson ◽  
D. Smith ◽  
K. Lyons ◽  
E. Miyawaki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Globus Pallidus ◽  
High Frequency ◽  
High Frequency Stimulation ◽  
Frequency Stimulation ◽  
Stimulation Of

High frequency stimulation of the subthalamic nucleus impacts adult neurogenesis in a rat model of Parkinson's disease

2011 ◽  
Vol 42 (3) ◽  
pp. 284-291 ◽  
Author(s):  
Vitaly Khaindrava ◽  
Pascal Salin ◽  
Christophe Melon ◽  
Michael Ugrumov ◽  
Lydia Kerkerian-Le-Goff ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Adult Neurogenesis ◽  
Rat Model ◽  
High Frequency ◽  
High Frequency Stimulation ◽  
Frequency Stimulation ◽  
Stimulation Of

Commentary: Dealing with the Aftermath

2016 ◽  
Vol 25 (4) ◽  
pp. 750-751
Author(s):  
Yves Agid
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
High Frequency ◽  
High Frequency Stimulation ◽  
Frequency Stimulation ◽  
Stimulation Of

In 2006, our team reported our experience in the use of bilateral high-frequency stimulation of the subthalamic nucleus (STN) in patients with severe levodopa-responsive forms of Parkinson’s disease (PD).1 The aim was to better understand and manage the difficulties experienced by patients who undergo neurosurgery, and by their families.

High Frequency Stimulation of the Subthalamic Nucleus as a Treatment for Parkinson's Disease: A 12 Month Follow-up Study

Neurosurgery ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 717-718
Author(s):  
Isabelle Germano ◽  
C. W. Olanow ◽  
J. M. Gracies ◽  
D. Weisz ◽  
J. C. Bucobo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
High Frequency ◽  
High Frequency Stimulation ◽  
Follow Up Study ◽  
Frequency Stimulation ◽  
Stimulation Of

scholarly journals Contrasting Changes in Cortical Activation Induced by Acute High-Frequency Stimulation within the Globus Pallidus in Parkinson's Disease

2008 ◽  
Vol 29 (2) ◽  
pp. 235-243 ◽  
Author(s):  
Pierre Payoux ◽  
Philippe Remy ◽  
Malika Miloudi ◽  
Jean-Luc Houeto ◽  
Claudio Stadler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Globus Pallidus ◽  
High Frequency ◽  
Premotor Cortex ◽  
Synaptic Activity ◽  
Cortical Activation ◽  
High Frequency Stimulation ◽  
Clinical Effects ◽  
Frequency Stimulation

Continuous stimulation of the globus pallidus (GP) has been shown to be an effective treatment for Parkinson's disease (PD). We used the fact that the implanted quadripolar leads contain electrodes within the GPi and GPe to investigate the clinical effects of acute high-frequency stimulation applied in these nuclei and changes in regional cerebral blood flow (rCBF) as an index of synaptic activity. In five patients treated by chronic GP stimulation, we compared the effects on PD symptoms and the changes in rCBF at rest and during paced right-hand movements, with and without left GPe or GPi stimulation. Although improving contralateral rigidity and akinesia, left GPe stimulation decreased rCBF in the left cerebellum and lateral premotor cortex at rest and significantly increased it in the left primary sensorimotor cortex (SM1) during movement. In contrast, left ventral GPi stimulation, which improved rigidity and worsened akinesia, decreased rCBF in the left SM1, premotor area, anterior cingulum, and supplementary motor area but did not modify the movement-related activation. GPe stimulation seems to result in a reduced activity of motor-related areas and the facilitation of motor cortex activation during movement, the latter component being absent during GPi stimulation, and this may explain the observed worsening of akinesia.

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