Differences in Connectivity among the Basal Ganglia, Cerebellum, and Supplementary Motor Area in Parkinson's Disease and Healthy Controls during Predictive Motor Timing (IN6-1.006)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. IN6-1.006-IN6-1.006
Author(s):  
M. Bares ◽  
I. Husarova ◽  
M. Mikl ◽  
O. Lungu ◽  
R. Marecek ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Supplementary Motor Area ◽  
Motor Area ◽  
Healthy Controls ◽  
Motor Timing

scholarly journals Neural signatures of hyperdirect pathway activity in Parkinson’s disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ashwini Oswal ◽  
Chunyan Cao ◽  
Chien-Hung Yeh ◽  
Wolf-Julian Neumann ◽  
James Gratwicke ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Supplementary Motor Area ◽  
Computational Modelling ◽  
Motor Area ◽  
Internal Globus Pallidus ◽  
Pathway Activity ◽  
High Beta ◽  
Beta Frequency

AbstractParkinson’s disease (PD) is characterised by the emergence of beta frequency oscillatory synchronisation across the cortico-basal-ganglia circuit. The relationship between the anatomy of this circuit and oscillatory synchronisation within it remains unclear. We address this by combining recordings from human subthalamic nucleus (STN) and internal globus pallidus (GPi) with magnetoencephalography, tractography and computational modelling. Coherence between supplementary motor area and STN within the high (21–30 Hz) but not low (13-21 Hz) beta frequency range correlated with ‘hyperdirect pathway’ fibre densities between these structures. Furthermore, supplementary motor area activity drove STN activity selectively at high beta frequencies suggesting that high beta frequencies propagate from the cortex to the basal ganglia via the hyperdirect pathway. Computational modelling revealed that exaggerated high beta hyperdirect pathway activity can provoke the generation of widespread pathological synchrony at lower beta frequencies. These findings suggest a spectral signature and a pathophysiological role for the hyperdirect pathway in PD.

scholarly journals Excitability of the supplementary motor area in Parkinson's disease depends on subcortical damage

2019 ◽  
Vol 12 (1) ◽  
pp. 152-160 ◽  
Author(s):  
Silvia Casarotto ◽  
Francesco Turco ◽  
Angela Comanducci ◽  
Alessio Perretti ◽  
Giorgio Marotta ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Supplementary Motor Area ◽  
Motor Area

Correlation between Bereitschaftspotential and reaction time measurements in patients with Parkinson's disease measuring the impaired supplementary motor area function?

1997 ◽  
Vol 147 (2) ◽  
pp. 177-183 ◽  
Author(s):  
Saša R. Filipović ◽  
Nadežda Čovičković-Šternić ◽  
Vladan M. Radović ◽  
Nataša Dragašević ◽  
Marina Stojanović-Svetel ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Reaction Time ◽  
Supplementary Motor Area ◽  
Motor Area ◽  
Area Function

scholarly journals Modeling Accuracy and Variability of Motor Timing in Treated and Untreated Parkinson’s Disease and Healthy Controls

2011 ◽  
Vol 5 ◽  
Author(s):  
Catherine R. G. Jones ◽  
Daniel O. Claassen ◽  
Minhong Yu ◽  
Jeffrey R. Spies ◽  
Tim Malone ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Healthy Controls ◽  
Motor Timing ◽  
Modeling Accuracy

Theta burst stimulation over the supplementary motor area in Parkinson’s disease

2014 ◽  
Vol 262 (2) ◽  
pp. 357-364 ◽  
Author(s):  
Carsten Eggers ◽  
Miriam Günther ◽  
John Rothwell ◽  
Lars Timmermann ◽  
Diane Ruge
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Supplementary Motor Area ◽  
Motor Area ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

scholarly journals Deficient supplementary motor area at rest: Neural basis of limb kinetic deficits in Parkinson's disease

2018 ◽  
Vol 39 (9) ◽  
pp. 3691-3700 ◽  
Author(s):  
Stefanie Kübel ◽  
Katharina Stegmayer ◽  
Tim Vanbellingen ◽  
Sebastian Walther ◽  
Stephan Bohlhalter
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Supplementary Motor Area ◽  
Motor Area ◽  
Neural Basis

scholarly journals Effects of magnetic stimulation over supplementary motor area on movement in Parkinson's disease

Brain ◽  
1996 ◽  
Vol 119 (3) ◽  
pp. 815-822 ◽  
Author(s):  
Ross Cunnington ◽  
Robert Iansek ◽  
Gary W. Thickbroom ◽  
Bev A. Laing ◽  
Frank L. Mastaglia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Stimulation ◽  
Supplementary Motor Area ◽  
Motor Area
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