The Analgesic Effect of Tramadol After Intravenous Injection in Healthy Volunteers in Relation to CYP2D6

OBJECTIVE:To investigate the analgesic and nonanalgesic effects and the pharmacokinetics of an intravenous infusion of 2 mg hydromorphone over 20 mins.DESIGN:Open study.SUBJECTS:Twelve healthy volunteers.MEASUREMENTS:The analgesic effect of hydromorphone was evaluated serially using pressure pain thresholds (PPTs) measured on the third fingers and toes. The nonanalgesic effects of hydromorphone were measured as miosis, decrease of saliva production and central nervous effects such as euphoria/dysphoria, nausea, headache, fatigue and feeling of heaviness. Plasma concentration of hydromorphone was measured using high performance liquid chromatography.RESULTS:PPTs were significantly increased compared with baseline levels for up to 2 h after the infusion of hydromorphone. Significant miosis and reduction of saliva production were registered up to 6 h after drug administration. Fatigue and heaviness were reported by all subjects. In the studied opioid-naive subjects, the hydromorphone-induced analgesic effect was of shorter duration than the studied nonanalgesic effects. The terminal elimination half-life of hydromorphone was 1.87±0.4 h (± SD) (95% CI 1.61 to 2.13), systemic clearance was 1.81±0.25 L/min (95% CI 1.65 to 1.97) and volume of distribution was 4.15±0.86 L/kg (95% CI 3.6 to 4.71).CONCLUSION:Analgesia and nonanalgesic effects appear to be well correlated with the plasma concentrations of the hydromorphone.

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The pharmacokinetics of ondansetron after intravenous injection in healthy volunteers phenotyped as poor or extensive metabolisers of debrisoquine.

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.1994.tb04294.x ◽

1994 ◽

Vol 37 (4) ◽

pp. 389-391 ◽

Cited By ~ 23

Author(s):

EI Ashforth ◽

JL Palmer ◽

A Bye ◽

A Bedding

Keyword(s):

Healthy Volunteers ◽

Intravenous Injection ◽

Extensive Metabolisers

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Pharmacoepidiological study of the effectiveness of procaine (novocaine) in combination with other drugs in the treatment of pain syndrome in acute pancreatitis

Medicine and Physical Education: Science and Practice ◽

10.20310/2658-7688-2020-2-2(6)-7-19 ◽

2020 ◽

pp. 7-19

Author(s):

Valery B. МAKSIMENKO ◽

Esedulla M. ОSMANOV ◽

Marina V. MAKEDONSKAYA ◽

Arkady I. TRUFANOV ◽

Luka A. GROMAKOV

Keyword(s):

Acute Pancreatitis ◽

Gastric Secretion ◽

Intravenous Injection ◽

Analgesic Effect ◽

Pain Syndrome ◽

Case Histories ◽

Pharmacological Agents ◽

Clinical Hospital ◽

Surgery Department ◽

Old Men

The purpose of the study : on the base of statistical and pharmacoepidemiological researches to study the effectiveness of procaine (novocaine) and to develop optimal combinations of pharmacological agents in the treatment of pain in acute pancreatitis. Materials and methods . In a cohort retrospective research, we studied case histories of 131 patients with acute pancreatitis who were treated at Surgery Department of Archbishop Luka City Clinical Hospital of Tambov. Among them, 71 men (54.2 %) and 60 women (45.8 %), whose average age was 52.5, including 46 years old men and 59 years old women. We studied the number of medicines used to treat the pain syndrome, the time of its relief, and made a pharmacoepidemiological assessment of the effectiveness of treatment with novocaine in combination with various drugs. Procaine was injected intravenously in the form of a 0.25-0.5 % solution. Results . We found out that combination of procaine with non-steroidal anti-inflammatory medicines and gastric secretion blockers have an effective analgesic effect. Treatment of pain by intravenous injection of a solution of novocaine and its combination with anticholinergic and myotrop antispasmodics was ineffective.

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Changes in Disappearance of Intravenously Administered 47Ca at the Onset of Alimentary Absorption of Unlabelled Calcium

Clinical Science ◽

10.1042/cs0460311 ◽

1974 ◽

Vol 46 (3) ◽

pp. 311-316

Author(s):

J. Kocián ◽

V. Brodan

Keyword(s):

Gastrointestinal Tract ◽

Healthy Volunteers ◽

Intravenous Injection ◽

Calcium Concentration ◽

Calcium Absorption ◽

Specific Radioactivity ◽

Rapid Decline ◽

Short Term ◽

Serum Calcium Concentration ◽

Temporary Rise

1. Administration of a large amount of unlabelled calcium orally 60 min after intravenous injection of 47Ca leads to a temporary rise of serum specific radioactivity in healthy volunteers. 2. This short-term rise is followed by a more rapid decline and in some instances by oscillations of specific radioactivity. 3. Both these effects could be caused by secretion of thyrocalcitonin resulting from a rise of serum calcium concentration during calcium absorption from the gastrointestinal tract.

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