scholarly journals Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development

Development ◽  
2007 ◽  
Vol 134 (24) ◽  
pp. 4405-4415 ◽  
Author(s):  
S. Raft ◽  
E. J. Koundakjian ◽  
H. Quinones ◽  
C. S. Jayasena ◽  
L. V. Goodrich ◽  
...  
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Sensory Hair ◽  
Ear Development ◽  
Inner Ear Development ◽  
Sensory Hair Cells

scholarly journals Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development

Biology Open ◽  
2017 ◽  
Vol 6 (9) ◽  
pp. 1270-1278 ◽  
Author(s):  
Simone Schwarzer ◽  
Sandra Spieß ◽  
Michael Brand ◽  
Stefan Hans
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Sensory Hair ◽  
Ear Development ◽  
Inner Ear Development ◽  
Sensory Hair Cells

scholarly journals Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development

2017 ◽  
Vol 423 (2) ◽  
pp. 126-137 ◽  
Author(s):  
Jeremy S. Duncan ◽  
Michelle L. Stoller ◽  
Andrew F. Francl ◽  
Fadel Tissir ◽  
Danelle Devenport ◽  
...  
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Planar Polarity ◽  
Ear Development ◽  
Vestibular Hair Cells ◽  
Inner Ear Development

scholarly journals Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle

Development ◽  
2020 ◽  
Vol 147 (22) ◽  
pp. dev192849
Author(s):  
Evan M. Ratzan ◽  
Anne M. Moon ◽  
Michael R. Deans
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Hair Cells ◽  
Conditional Knockout ◽  
Developmental Model ◽  
Type I ◽  
Ear Development ◽  
Inner Ear Development ◽  
Morphological Criteria ◽  
Genetic Labeling

ABSTRACTFGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from otic placode induction to cellular differentiation in the organ of Corti. As a secreted morphogen with diverse functions, Fgf8 expression is likely to be spatially restricted and temporally dynamic throughout inner ear development. We evaluated these characteristics using genetic labeling mediated by Fgf8mcm gene-targeted mice and determined that Fgf8 expression is a specific and early marker of Type-I vestibular hair cell identity. Fgf8mcm expression initiates at E11.5 in the future striolar region of the utricle, labeling hair cells following EdU birthdating, and demonstrates that sub-type identity is determined shortly after terminal mitosis. This early fate specification is not apparent using markers or morphological criteria that are not present before birth in the mouse. Although analyses of Fgf8 conditional knockout mice did not reveal developmental phenotypes, the restricted pattern of Fgf8 expression suggests that functionally redundant FGF ligands may contribute to vestibular hair cell differentiation and supports a developmental model in which Type-I and Type-II hair cells develop in parallel rather than from an intermediate precursor.

Cod106, a novel synaptic protein expressed in sensory hair cells of the inner ear and in CNS neurons

2005 ◽  
Vol 28 (1) ◽  
pp. 106-117 ◽  
Author(s):  
Ellen Reisinger ◽  
Ulrike Zimmermann ◽  
Marlies Knipper ◽  
Jost Ludwig ◽  
Nikolaj Klöcker ◽  
...  
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Synaptic Protein ◽  
Sensory Hair ◽  
Sensory Hair Cells ◽  
Cns Neurons

scholarly journals Filling the Silent Void: Genetic Therapies for Hearing Impairment

2012 ◽  
Vol 2012 ◽  
pp. 1-9
Author(s):  
Joel Sng ◽  
Thomas Lufkin
Keyword(s):  
Inner Ear ◽  
Hearing Impairment ◽  
Hair Cells ◽  
Genetic Disorders ◽  
Environmental Damage ◽  
Inner Ear Development ◽  
Sensory Hair Cells ◽  
And Function ◽  
Function Potential

The inner ear cytoarchitecture forms one of the most intricate and delicate organs in the human body and is vulnerable to the effects of genetic disorders, aging, and environmental damage. Owing to the inability of the mammalian cochlea to regenerate sensory hair cells, the loss of hair cells is a leading cause of deafness in humans. Millions of individuals worldwide are affected by the emotionally and financially devastating effects of hearing impairment (HI). This paper provides a brief introduction into the key role of genes regulating inner ear development and function. Potential future therapies that leverage on an improved understanding of these molecular pathways are also described in detail.

Sign in / Sign up

Export Citation Format

Share Document