scholarly journals Upregulation of Mitimere and Nubbin acts through Cyclin E to confer self-renewing asymmetric division potential to neural precursor cells

Development ◽  
2004 ◽  
Vol 131 (5) ◽  
pp. 1123-1134 ◽  
Author(s):  
K. M. Bhat
Keyword(s):  
Cyclin E ◽  
Asymmetric Division ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

scholarly journals Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS

Development ◽  
2001 ◽  
Vol 128 (16) ◽  
pp. 3161-3168 ◽  
Author(s):  
Brijesh Mehta ◽  
Krishna Moorthi Bhat
Keyword(s):  
Signaling Pathway ◽  
Asymmetric Division ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Down Regulation ◽  
Over Expression ◽  
Symmetric Division ◽  
A Cell ◽  
Mother Cells

The bipotential Ganglion Mother Cells, or GMCs, in the DrosophilaCNS asymmetrically divide to generate two distinct post-mitotic neurons. Here,we show that the midline repellent Slit (Sli), via its receptor Roundabout(Robo), promotes the terminal asymmetric division of GMCs. In GMC-1 of the RP2/sib lineage, Slit promotes asymmetric division by down regulating two POU proteins, Nubbin and Mitimere. The down regulation of these proteins allows the asymmetric localization of Inscuteable, leading to the asymmetric division of GMC-1. Consistent with this, over-expression of these POU genes in a late GMC-1 causes mis-localization of Insc and symmetric division of GMC-1 to generate two RP2s. Similarly, increasing the dosage of the two POU genes insli mutant background enhances the penetrance of the RP2 lineage defects whereas reducing the dosage of the two genes reduces the penetrance of the phenotype. These results tie a cell-non-autonomous signaling pathway to the asymmetric division of precursor cells during neurogenesis.

scholarly journals c-jun is differentially expressed in embryonic and adult neural precursor cells

2017 ◽  
Vol 147 (6) ◽  
pp. 721-731 ◽  
Author(s):  
Fumiaki Kawashima ◽  
Kengo Saito ◽  
Hirofumi Kurata ◽  
Yoshihiro Maegaki ◽  
Tetsuji Mori
Keyword(s):  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Differentially Expressed ◽  
Neural Precursor
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