scholarly journals MesenchymalHox6function is required for mouse pancreatic endocrine cell differentiation

Development ◽  
2015 ◽  
Vol 142 (22) ◽  
pp. 3859-3868 ◽  
Author(s):  
Brian M. Larsen ◽  
Steven M. Hrycaj ◽  
Micaleah Newman ◽  
Ye Li ◽  
Deneen M. Wellik
Keyword(s):  
Cell Differentiation ◽  
Endocrine Cell ◽  
Pancreatic Endocrine Cell

scholarly journals Glucose Is Necessary for Embryonic Pancreatic Endocrine Cell Differentiation

2007 ◽  
Vol 282 (20) ◽  
pp. 15228-15237 ◽  
Author(s):  
Ghislaine Guillemain ◽  
Gaëlle Filhoulaud ◽  
Gabriela Da Silva-Xavier ◽  
Guy A. Rutter ◽  
Raphaël Scharfmann
Keyword(s):  
Cell Differentiation ◽  
Endocrine Cell ◽  
Pancreatic Endocrine Cell

scholarly journals The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses Beta- to Delta-Cell Transdifferentiation

2021 ◽  
Author(s):  
Xuehua Liang ◽  
Hualin Duan ◽  
Yahui Mao ◽  
Ulrich Koestner ◽  
Yiqiu Wei ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Beta Cell ◽  
Endocrine Cell ◽  
Endocrine Cells ◽  
Cell Number ◽  
Pancreatic Endocrine Cell ◽  
Cell Transdifferentiation ◽  
Pancreatic Endocrine Cells ◽  
Delta Cell ◽  
Null Mutants

The allocation and specification of pancreatic endocrine lineages are tightly regulated by transcription factors. Disturbances in differentiation of these lineages contribute to the development of various metabolic diseases, including diabetes. The Insulinoma-associated protein 1 (<i>Insm1</i>), which encodes a protein containing one SNAG domain and five zinc fingers, plays essential roles in pancreatic endocrine cell differentiation and in mature beta-cell function. In the present study, we compared the differentiation of pancreatic endocrine cells between Insm1 null and Insm1 SNAG domain mutants (Insm1delSNAG) to explore the specific function of the SNAG domain of Insm1. We show that the delta-cell number is increased in Insm1delSNAG but not in Insm1 null mutants as compared to the control mice. We also show a less severe reduction of the beta-cell number in Insm1delSNAG as that in Insm1 null mutants. In addition, similar deficits are observed in alpha-, PP- and epsilon-cell in Insm1delSNAG and Insm1 null mutants. We further identified that the increased delta-cell number is due to beta- to delta-cell transdifferentiation. Mechanistically, the SNAG domain of Insm1 interacts with Lsd1, the demethylase of H3K4me1/2. Mutation in the SNAG domain of Insm1 results in impaired recruitment of Lsd1 and increased H3K4me1/2 levels at <i>H</i><i>hex</i> loci that are bound by Insm1, thereby promoting the transcriptional activity of the delta-cell-specific gene <i>Hhex</i>. Our study has identified a novel function of the SNAG domain of Insm1 in the regulation of pancreatic endocrine cells differentiation, particularly in the repression of beta- to delta-cell transdifferentiation.

The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses Beta- to Delta-Cell Transdifferentiation

Diabetes ◽  
2021 ◽  
pp. db200883
Author(s):  
Xuehua Liang ◽  
Hualin Duan ◽  
Yahui Mao ◽  
Ulrich Koestner ◽  
Yiqiu Wei ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Endocrine Cell ◽  
Pancreatic Endocrine Cell ◽  
Cell Transdifferentiation ◽  
Delta Cell

scholarly journals The Pax6b Homeodomain Is Dispensable for Pancreatic Endocrine Cell Differentiation in Zebrafish

2010 ◽  
Vol 285 (18) ◽  
pp. 13863-13873 ◽  
Author(s):  
Vincianne Verbruggen ◽  
Olivier Ek ◽  
Daphné Georlette ◽  
François Delporte ◽  
Virginie Von Berg ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Endocrine Cell ◽  
Pancreatic Endocrine Cell

scholarly journals The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses Beta- to Delta-Cell Transdifferentiation

2021 ◽  
Author(s):  
Xuehua Liang ◽  
Hualin Duan ◽  
Yahui Mao ◽  
Ulrich Koestner ◽  
Yiqiu Wei ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Beta Cell ◽  
Endocrine Cell ◽  
Endocrine Cells ◽  
Cell Number ◽  
Pancreatic Endocrine Cell ◽  
Cell Transdifferentiation ◽  
Pancreatic Endocrine Cells ◽  
Delta Cell ◽  
Null Mutants

The allocation and specification of pancreatic endocrine lineages are tightly regulated by transcription factors. Disturbances in differentiation of these lineages contribute to the development of various metabolic diseases, including diabetes. The Insulinoma-associated protein 1 (<i>Insm1</i>), which encodes a protein containing one SNAG domain and five zinc fingers, plays essential roles in pancreatic endocrine cell differentiation and in mature beta-cell function. In the present study, we compared the differentiation of pancreatic endocrine cells between Insm1 null and Insm1 SNAG domain mutants (Insm1delSNAG) to explore the specific function of the SNAG domain of Insm1. We show that the delta-cell number is increased in Insm1delSNAG but not in Insm1 null mutants as compared to the control mice. We also show a less severe reduction of the beta-cell number in Insm1delSNAG as that in Insm1 null mutants. In addition, similar deficits are observed in alpha-, PP- and epsilon-cell in Insm1delSNAG and Insm1 null mutants. We further identified that the increased delta-cell number is due to beta- to delta-cell transdifferentiation. Mechanistically, the SNAG domain of Insm1 interacts with Lsd1, the demethylase of H3K4me1/2. Mutation in the SNAG domain of Insm1 results in impaired recruitment of Lsd1 and increased H3K4me1/2 levels at <i>H</i><i>hex</i> loci that are bound by Insm1, thereby promoting the transcriptional activity of the delta-cell-specific gene <i>Hhex</i>. Our study has identified a novel function of the SNAG domain of Insm1 in the regulation of pancreatic endocrine cells differentiation, particularly in the repression of beta- to delta-cell transdifferentiation.

scholarly journals Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans

Diabetologia ◽  
2007 ◽  
Vol 50 (3) ◽  
pp. 585-595 ◽  
Author(s):  
S. Zertal-Zidani ◽  
A. Bounacer ◽  
R. Scharfmann
Keyword(s):  
Cell Differentiation ◽  
Endocrine Cell ◽  
Pancreatic Endocrine Cell

scholarly journals Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish

2017 ◽  
Vol 8 ◽  
Author(s):  
Lisette A. Maddison ◽  
Wenbiao Chen
Keyword(s):  
Endocrine Cell ◽  
Cell Adaptation ◽  
Pancreatic Endocrine Cell

scholarly journals Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment

Development ◽  
2018 ◽  
Vol 145 (6) ◽  
pp. dev163162 ◽  
Author(s):  
Xin-Xin Yu ◽  
Wei-Lin Qiu ◽  
Liu Yang ◽  
Lin-Chen Li ◽  
Yu-Wei Zhang ◽  
...  
Keyword(s):  
Cell Fate ◽  
Endocrine Cell ◽  
Pancreatic Endocrine Cell

scholarly journals Specifying pancreatic endocrine cell fates

2006 ◽  
Vol 123 (7) ◽  
pp. 501-512 ◽  
Author(s):  
Patrick Collombat ◽  
Jacob Hecksher-Sørensen ◽  
Palle Serup ◽  
Ahmed Mansouri
Keyword(s):  
Endocrine Cell ◽  
Cell Fates ◽  
Pancreatic Endocrine Cell
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