A new isoform ofDrosophilanon-muscle Tropomyosin 1 interacts with Kinesin-1 and functions inoskarmRNA localization

Development ◽  
2016 ◽  
Vol 143 (23) ◽  
pp. e1.2-e1.2
Author(s):  
Rajalakshmi Veeranan-Karmegam ◽  
Devi Prasad Boggupalli ◽  
Guojun Liu ◽  
Graydon B. Gonsalvez
Keyword(s):  
Muscle Tropomyosin

scholarly journals The amino terminus of muscle tropomyosin is a major determinant for function.

1990 ◽  
Vol 265 (1) ◽  
pp. 538-545
Author(s):  
Y J Cho ◽  
J Liu ◽  
S E Hitchcock-DeGregori
Keyword(s):  
Major Determinant ◽  
Amino Terminus ◽  
Muscle Tropomyosin

scholarly journals Control of the Initiation and Termination of Kinesin-1-Driven Transport by Myosin-Ic and Non-Muscle Tropomyosin

2015 ◽  
Vol 108 (2) ◽  
pp. 598a
Author(s):  
Betsy B. McIntosh ◽  
Erika L.F. Holzbaur ◽  
E. Michael Ostap
Keyword(s):  
Muscle Tropomyosin

scholarly journals Alterations in flight muscle ultrastructure and function in Drosophila tropomyosin mutants.

1996 ◽  
Vol 135 (3) ◽  
pp. 673-687 ◽  
Author(s):  
A J Kreuz ◽  
A Simcox ◽  
D Maughan
Keyword(s):  
Amino Acid ◽  
Power Output ◽  
Flight Muscle ◽  
Structure And Function ◽  
Wild Type ◽  
Muscle Tropomyosin ◽  
Ultrastructure And Function ◽  
And Function ◽  
Net Power Output ◽  
Current Report

Drosophila indirect flight muscle (IFM) contains two different types of tropomyosin: a standard 284-amino acid muscle tropomyosin, Ifm-TmI, encoded by the TmI gene, and two > 400 amino acid tropomyosins, TnH-33 and TnH-34, encoded by TmII. The two IFM-specific TnH isoforms are unique tropomyosins with a COOH-terminal extension of approximately 200 residues which is hydrophobic and rich in prolines. Previous analysis of a hypomorphic TmI mutant, Ifm(3)3, demonstrated that Ifm-TmI is necessary for proper myofibrillar assembly, but no null TmI mutant or TmII mutant which affects the TnH isoforms have been reported. In the current report, we show that four flightless mutants (Warmke et al., 1989) are alleles of TmI, and characterize a deficiency which deletes both TmI and TmII. We find that haploidy of TmI causes myofibrillar disruptions and flightless behavior, but that haploidy of TmII causes neither. Single fiber mechanics demonstrates that power output is much lower in the TmI haploid line (32% of wild-type) than in the TmII haploid line (73% of wild-type). In myofibers nearly depleted of Ifm-TmI, net power output is virtually abolished (< 1% of wild-type) despite the presence of an organized fibrillar core (approximately 20% of wild-type). The results suggest Ifm-TmI (the standard tropomyosin) plays a key role in fiber structure, power production, and flight, with reduced Ifm-TmI expression producing corresponding changes of IFM structure and function. In contrast, reduced expression of the TnH isoforms has an unexpectedly mild effect on IFM structure and function.

The isolation of cod muscle tropomyosin by heat treatment

1969 ◽  
Vol 188 (1) ◽  
pp. 124-131 ◽  
Author(s):  
P.H. Odense ◽  
T.C. Leung ◽  
W.A. Green ◽  
J.R. Dingle
Keyword(s):  
Heat Treatment ◽  
Muscle Tropomyosin

Production and crystallization of lobster muscle tropomyosin expressed in Sf9 cells

FEBS Letters ◽  
1996 ◽  
Vol 394 (2) ◽  
pp. 201-205 ◽  
Author(s):  
Andrea Miegel ◽  
Ken-Ichi Sano ◽  
Kazuhiro Yamamoto ◽  
Kayo Maeda ◽  
Yuichiro Maéda ◽  
...  
Keyword(s):  
Sf9 Cells ◽  
Muscle Tropomyosin

A processed gene defining a gene family encoding a human non-muscle tropomyosin

1983 ◽  
Vol 167 (3) ◽  
pp. 523-537 ◽  
Author(s):  
Alexander R. MacLeod ◽  
Kathleen Talbot ◽  
H.E. Huxley
Keyword(s):  
Gene Family ◽  
Muscle Tropomyosin

Functional properties of non-muscle tropomyosin isoforms

1994 ◽  
Vol 6 (1) ◽  
pp. 96-104 ◽  
Author(s):  
Mark F. Pittenger ◽  
Jeffrey A. Kazzaz ◽  
David M. Helfman
Keyword(s):  
Functional Properties ◽  
Tropomyosin Isoforms ◽  
Muscle Tropomyosin

scholarly journals Renaturation of skeletal muscle tropomyosin: implications for in vivo assembly.

1985 ◽  
Vol 82 (8) ◽  
pp. 2359-2363 ◽  
Author(s):  
H. R. Brown ◽  
F. H. Schachat
Keyword(s):  
Skeletal Muscle ◽  
Muscle Tropomyosin

Chemical evidence for chain heterogeneity in rabbit muscle tropomyosin

1970 ◽  
Vol 41 (4) ◽  
pp. 987-994 ◽  
Author(s):  
R.S. Hodges ◽  
L.B. Smillie
Keyword(s):  
Rabbit Muscle ◽  
Muscle Tropomyosin ◽  
Chemical Evidence

Shark skeletal muscle tropomyosin is a phosphoprotein

2008 ◽  
Vol 29 (2-5) ◽  
pp. 101-107 ◽  
Author(s):  
Michael Hayley ◽  
Tatiana Chevaldina ◽  
Wasana A. K. A. Mudalige ◽  
Donna M. Jackman ◽  
Alvin D. Dobbin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Tropomyosin
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