scholarly journals Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events

2008 ◽  
Vol 122 (1) ◽  
pp. 75-82 ◽  
Author(s):  
X. Xia ◽  
V. Lessmann ◽  
T. F. J. Martin
Keyword(s):  
Hippocampal Neurons ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Vesicle Exocytosis

scholarly journals Role of the polybasic sequence in the Doc2α C2B domain in dense-core vesicle exocytosis in PC12 cells

2010 ◽  
pp. no-no ◽  
Author(s):  
Mai Sato ◽  
Yasunori Mori ◽  
Takahide Matsui ◽  
Ryo Aoki ◽  
Manami Oya ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Vesicle Exocytosis

Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells

10.1038/nn869 ◽  
2002 ◽  
Vol 5 (7) ◽  
pp. 649-656 ◽  
Author(s):  
Ok-Ho Shin ◽  
Josep Rizo ◽  
Thomas C. Südhof
Keyword(s):  
Pc12 Cells ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Vesicle Exocytosis

scholarly journals Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I

2001 ◽  
Vol 98 (20) ◽  
pp. 11680-11685 ◽  
Author(s):  
T. Voets ◽  
T. Moser ◽  
P.-E. Lund ◽  
R. H. Chow ◽  
M. Geppert ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Calcium Dependence ◽  
Large Dense Core Vesicle ◽  
Synaptotagmin I ◽  
Vesicle Exocytosis

scholarly journals Activation of intracellular transport by relieving KIF1C autoinhibition

2018 ◽  
Author(s):  
Nida Siddiqui ◽  
Alice Bachmann ◽  
Alexander James Zwetsloot ◽  
Hamdi Hussain ◽  
Daniel Roth ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Intracellular Transport ◽  
Tyrosine Phosphatase ◽  
Dense Core ◽  
Release Mechanism ◽  
Dense Core Vesicle ◽  
Ferm Domain ◽  
Cargo Transport ◽  
Binding Surface

AbstractThe kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of KIF1C. We show that the microtubule binding surface of KIF1C motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase PTPN21. The FERM domain of PTPN21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in KIF1C-depleted cells. In vitro, human full-length KIF1C is a processive, plus-end directed motor. Its landing rate onto microtubules increases in the presence of either PTPN21 FERM domain or the cargo adapter Hook3 that binds the same region of KIF1C tail. This autoinhibition release mechanism allows cargo-activated transport and might enable motors to participate in bidirectional cargo transport without undertaking a tug-of-war.

scholarly journals CAPS Acts at a Prefusion Step in Dense-Core Vesicle Exocytosis as a PIP2 Binding Protein

Neuron ◽  
2004 ◽  
Vol 43 (4) ◽  
pp. 551-562 ◽  
Author(s):  
Ruslan N Grishanin ◽  
Judith A Kowalchyk ◽  
Vadim A Klenchin ◽  
Kyougsook Ann ◽  
Cynthia A Earles ◽  
...  
Keyword(s):  
Binding Protein ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Vesicle Exocytosis
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