5-Bromodeoxyuridine-induced formation of virus-like particles in Naegleria gruberi EGs
Keyword(s):
Exposure of axenic cultures of the amoeboflagellate Naegleria gruberi EGs to the thymidine analogue 5-bromo-2′-deoxyuridine (BrdU) resulted in the induction of virus-like particles (VLP) and various structures associated with their development and presumed transmission. Previously, VLP induction could be accomplished only by growing amoebae in the presence of living bacteria as a food source. Addition of excess thymidine along with BrdU did not block induction of particles. This account demonstrates that the EGs-VLP system responded to BrdU as do a number of mammalian cell lines harbouring latent viruses, and provides the basis for future work on the infectivity of the VLPs for other amoebae as well as tissue culture cells.
1964 ◽
Vol 33
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pp. 301-309
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1969 ◽
Vol 27
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pp. 376-377
1993 ◽
Vol 51
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pp. 342-343
1976 ◽
Vol 18
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pp. 1147-1150
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1982 ◽
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pp. 1530-1536
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1973 ◽
Vol 248
(19)
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pp. 6738-6743
1976 ◽
Vol 251
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pp. 6747-6756
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1979 ◽
Vol 254
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pp. 3935-3946
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1978 ◽
Vol 253
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pp. 4408-4418
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1978 ◽
Vol 253
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pp. 6125-6131
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