Blood Flow Measurement Using a Highly Filled Carbon Polymer Sandwich Sensor and an Elasto-Pseudo Compressible Vascular Flow

Vascular grafts are widely employed in clinical practice and still pose significant problems of compatibility and longevity, particularly when the prosthesis is to replace arteries of small diameter. Once a graft has been implanted in the vascular tree, there is no easy way of assessing its interactions with the surrounding tissue. Doppler flow probes or some imaging techniques are commonly used to monitor flow velocity in vascular prostheses. It is, however, difficult to monitor a patient's recovery on a continuous basis. Continuous means of measurement can be quite invaluable. This paper presents a high-carbon filled polymer (HCFP) sensor that is developed for blood flow measurement in vascular grafts. Furthermore, a computational fluid dynamics model of incompressible blood flow in elastic blood vessels is presented.

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7D47 Blood flow measurement in the cerebral microvessels with fluorescent imaging techniques.

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME ◽

10.1299/jsmebio.2012.24._7d47-1_ ◽

2012 ◽

Vol 2012.24 (0) ◽

pp. _7D47-1_-_7D47-2_

Author(s):

Daiki YAMAGUCHI ◽

Kouichi YOSHIHARA ◽

Takuma SUGASHI ◽

Daigo SHIRAHATA ◽

Hiroyuki TAKUWA ◽

...

Keyword(s):

Blood Flow ◽

Flow Measurement ◽

Imaging Techniques ◽

Fluorescent Imaging ◽

Blood Flow Measurement ◽

Cerebral Microvessels

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Correlation of γ-radioactivity and Scanning Electron Microscopy in measurement of retention of 111Indium-labeled canine endothelial cells on synthetic vascular grafts

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100156419 ◽

1989 ◽

Vol 47 ◽

pp. 886-887

Author(s):

E.J. Prendiville ◽

S. Laliberté Verdon ◽

K. E. Gould ◽

K. Ramberg ◽

R. J. Connolly ◽

...

Keyword(s):

Blood Flow ◽

Ex Vivo ◽

Vascular Grafts ◽

Retention Data ◽

Vascular Prostheses ◽

Group 4 ◽

Human Fibronectin ◽

Insufficient Time ◽

Group 3 ◽

Group 2

Endothelial cell (EC) seeding is postulated as a mechanism of improving patency in small caliber vascular grafts. However the majority of seeded EC are lost within 24 hours of restoration of blood flow in previous canine studies . We postulate that the cells have insufficient time to fully develop their attachment to the graft surface prior to exposure to hemodynamic stress. We allowed EC to incubate on fibronectin-coated ePTFE grafts for four different time periods after seeding and measured EC retention after perfusion in a canine ex vivo shunt circuit.Autologous canine EC, were enzymatically harvested, grown to confluence, and labeled with 30 μCi 111 Indium-oxine/80 cm 2 flask. Four groups of 5 cm x 4 mm ID ePTFE vascular prostheses were coated with 1.5 μg/cm.2 human fibronectin, and seeded with 1.5 x 105 EC/ cm.2. After seeding grafts in Group 1 were incubated in complete growth medium for 90 minutes, Group 2 were incubated for 24 hours, Group 3 for 72 hours and Group 4 for 6 days. Grafts were then placed in the canine ex vivo circuit, constructed between femoral artery and vein, and subjected to blood flow of 75 ml per minute for 6 hours. Continuous counting of γ-activity was made possible by placing the seeded graft inside the γ-counter detection crystal for the duration of perfusion. EC retention data after 30 minutes, 2 hours and 6 hours of flow are shown in the table.

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MEASUREMENT OF BLOOD FLOW WITH FREELY DIFFUSIBLE INDICATORS AS INERT GASES, ANTIPYRINE, LABELLED WATER AND RUBIDIUM

Acta Endocrinologica ◽

10.1530/acta.0.069s095b ◽

1972 ◽

Vol 68 (2_Supplb) ◽

pp. S95-S111 ◽

Cited By ~ 9

Author(s):

Niels A. Lassen ◽

Ole Andrée Larsen

Keyword(s):

Blood Flow ◽

Flow Measurement ◽

Capillary Wall ◽

Inert Gases ◽

Tissue Blood Flow ◽

Blood Flow Measurement

ABSTRACT Indicators which freely cross the capillary wall can be used for measurement of tissue blood flow in many different ways. Basically one can distinguish two categories of methods, viz. the ones where the indicator enters the tissue via the inflowing blood and the ones where the indicator is deposited locally in the tissue. The most important methods are briefly described with special emphasis on the theory of blood flow measurement.

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