Adsorption of Metal Ions to Surface-Template Resins Prepared with Amphiphilic Styrene Monomers Bearing Amino Carboxylic Acid

1998 ◽  
Vol 71 (4) ◽  
pp. 789-796 ◽  
Author(s):  
Yoshifumi Koide ◽  
Keigo Tsujimoto ◽  
Hideto Shosenji ◽  
Mizuo Maeda ◽  
Makoto Takagi
Keyword(s):  
Carboxylic Acid ◽  
Metal Ions ◽  
Adsorption Of Metal Ions ◽  
Amino Carboxylic Acid

Synthesis, Characterization and In vitro Evaluation of N-Substituted- Sulfomoyl-Phenyl-Amino Carboxylic Acid Derivatives as Squalene Synthase Inhibitors

2019 ◽  
Vol 15 (4) ◽  
pp. 415-426
Author(s):  
Avani B. Chokshi ◽  
Mahesh T. Chhabria ◽  
Pritesh R. Desai
Keyword(s):  
Carboxylic Acid ◽  
Cell Line ◽  
Hepatic Cell ◽  
Squalene Synthase ◽  
Lipid Lowering ◽  
Assay Method ◽  
Aromatic Substituent ◽  
Hepatic Cell Line ◽  
Amino Carboxylic Acid

Background:Squalene Synthase is one of the cholesterol biosynthetic pathway enzymes, inhibition of which produces potent lipid lowering action. A variety of chemical classes have been evaluated for its inhibition to provide alternate antihyperlipidemic agents to statins.Methods:A series of N-substituted-sulfomoyl-phenyl-amino carboxylic acid derivatives were designed through pharmacophore modelling as Squalene Synthase inhibitors. We report here the synthesis, characterization and in vitro pharmacological screening of the designed molecules as Squalene synthase inhibitors. The target molecules were synthesized by a simple procedure and each molecule was characterized by IR, Mass, 1HNMR and 13CNMR spectroscopic techniques. As a primary site of action for cholesterol biosynthesis is liver, each of the molecules were first screened for in vitro cytotoxicity over human hepatic cell line (HepG2) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay method. The enzyme inhibition assay was performed on cell lysates prepared from HepG2 cells by Human Squalene Synthase ELISA kit, where test compounds were added in the nontoxic concentrations only.Results:Compound 5f was found to be most potent with the IC50 value of 11.91 µM. The CTC50 value for 5f on human hepatic cell line was > 1000 µM so it was considered that the compound was relatively safe and might be free of hepatotoxicity.Conclusion:From the results of our studies, it was observed that compounds with poly nuclear aromatic or hetero aromatic substituent on a side chain were more potent enzyme inhibitors and a distance of 4-5 atoms is optimum between amide nitrogen and hydroxyl group of carboxylic acid.

A comparative study on selective adsorption of metal ions using aminated adsorbents

2013 ◽  
Vol 395 ◽  
pp. 230-240 ◽  
Author(s):  
Len Foong Koong ◽  
Koon Fung Lam ◽  
John Barford ◽  
Gordon McKay
Keyword(s):  
Comparative Study ◽  
Metal Ions ◽  
Selective Adsorption ◽  
Adsorption Of Metal Ions

The influence of selected transition metal ions on the structure, thermal and microbiological properties of pyrazine-2-carboxylic acid

Polyhedron ◽  
2020 ◽  
Vol 175 ◽  
pp. 114173 ◽  
Author(s):  
Grzegorz Świderski ◽  
Sławomir Wojtulewski ◽  
Monika Kalinowska ◽  
Renata Świsłocka ◽  
Agnieszka Zofia Wilczewska ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Microbiological Properties

scholarly journals Adsorption of Metal Ions by Amidoxime-based Polyacrylic Fibers

2018 ◽  
Vol 6 ◽  
Author(s):  
Anup Tuladhar ◽  
Horng-Bin Pan ◽  
Chien Wai
Keyword(s):  
Metal Ions ◽  
Adsorption Of Metal Ions
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