scholarly journals Male Germline Stem Cell Division and Spermatocyte Growth Require Insulin Signaling in Drosophila

2009 ◽  
Vol 34 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Satoru Ueishi ◽  
Hanako Shimizu ◽  
Yoshihiro H. Inoue
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Insulin Signaling ◽  
Germline Stem Cell ◽  
Male Germline ◽  
Stem Cell Division

scholarly journals Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Cuie Chen ◽  
Mayu Inaba ◽  
Zsolt G Venkei ◽  
Yukiko M Yamashita
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Cell Fate ◽  
Germline Stem Cell ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Mother And Daughter ◽  
Stem Cell Divisions ◽  
Stem Cell Division ◽  
Male Germline Stem Cells

Asymmetric stem cell division is often accompanied by stereotypical inheritance of the mother and daughter centrosomes. However, it remains unknown whether and how stem cell centrosomes are uniquely regulated and how this regulation may contribute to stem cell fate. Here we identify Klp10A, a microtubule-depolymerizing kinesin of the kinesin-13 family, as the first protein enriched in the stem cell centrosome in Drosophila male germline stem cells (GSCs). Depletion of klp10A results in abnormal elongation of the mother centrosomes in GSCs, suggesting the existence of a stem cell-specific centrosome regulation program. Concomitant with mother centrosome elongation, GSCs form asymmetric spindle, wherein the elongated mother centrosome organizes considerably larger half spindle than the other. This leads to asymmetric cell size, yielding a smaller differentiating daughter cell. We propose that klp10A functions to counteract undesirable asymmetries that may result as a by-product of achieving asymmetries essential for successful stem cell divisions.

scholarly journals C. elegans Nucleostemin Is Required for Larval Growth and Germline Stem Cell Division

PLoS Genetics ◽  
2008 ◽  
Vol 4 (8) ◽  
pp. e1000181 ◽  
Author(s):  
Michelle M. Kudron ◽  
Valerie Reinke
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Larval Growth ◽  
Germline Stem Cell ◽  
C Elegans ◽  
Stem Cell Division
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