scholarly journals Clonidine Reduces Nociceptive Responses in Mouse Orofacial Formalin Model: Potentiation by Sigma-1 Receptor Antagonist BD1047 without Impaired Motor Coordination

2015 ◽  
Vol 38 (9) ◽  
pp. 1320-1327 ◽  
Author(s):  
Seo-Yeon Yoon ◽  
Suk-Yun Kang ◽  
Hyun-Woo Kim ◽  
Hyung-Chan Kim ◽  
Dae-Hyun Roh
Keyword(s):  
Receptor Antagonist ◽  
Motor Coordination ◽  
Sigma 1 Receptor ◽  
Nociceptive Responses ◽  
Sigma 1

scholarly journals TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain

2018 ◽  
Vol 115 (7) ◽  
pp. E1657-E1666 ◽  
Author(s):  
Miguel Ortíz-Rentería ◽  
Rebeca Juárez-Contreras ◽  
Ricardo González-Ramírez ◽  
León D. Islas ◽  
Félix Sierra-Ramírez ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Sigma 1 Receptor ◽  
Trpv1 Channels ◽  
Nociceptive Responses ◽  
Sigma 1 ◽  
Transient Receptor ◽  
Thermal Stimuli

The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed in nociceptors where, when activated by chemical or thermal stimuli, it functions as an important transducer of painful and itch-related stimuli. Although the interaction of TRPV1 with proteins that regulate its function has been previously explored, their modulation by chaperones has not been elucidated, as is the case for other mammalian TRP channels. Here we show that TRPV1 physically interacts with the Sigma 1 Receptor (Sig-1R), a chaperone that binds progesterone, an antagonist of Sig-1R and an important neurosteroid associated to the modulation of pain. Antagonism of Sig-1R by progesterone results in the down-regulation of TRPV1 expression in the plasma membrane of sensory neurons and, consequently, a decrease in capsaicin-induced nociceptive responses. This is observed both in males treated with a synthetic antagonist of Sig-1R and in pregnant females where progesterone levels are elevated. This constitutes a previously undescribed mechanism by which TRPV1-dependent nociception and pain can be regulated.

Sigma‐1 receptor antagonist ( BD ‐1063) potentiates the antinociceptive effect of quercetin in neuropathic pain induced by chronic constriction injury

2020 ◽  
Author(s):  
Josué Vidal Espinosa‐Juárez ◽  
Osmar Antonio Jaramillo‐Morales ◽  
Myrna Déciga‐Campos ◽  
Luis Alfonso Moreno‐Rocha ◽  
Francisco Javier López‐Muñoz
Keyword(s):  
Neuropathic Pain ◽  
Receptor Antagonist ◽  
Chronic Constriction Injury ◽  
Antinociceptive Effect ◽  
Sigma 1 Receptor ◽  
Sigma 1

216 A NEW SELECTIVE SIGMA-1 RECEPTOR ANTAGONIST (S1RA) REDUCES NEUROPATHIC PAIN BEHAVIORS AND ACTIVITY-INDUCED SPINAL SENSITISATION

2010 ◽  
Vol 4 (S1) ◽  
pp. 63-63 ◽  
Author(s):  
D. Zamanillo ◽  
L. Romero ◽  
J. Burgueño ◽  
X. Nadal ◽  
A. Dordal ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Receptor Antagonist ◽  
Sigma 1 Receptor ◽  
Pain Behaviors ◽  
Sigma 1
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