Anti-inflammatory constituents of topically applied crude drugs. IV. Constituents and anti-inflammatory effect of Paraguayan crude drug "Alhucema"(Lavandula latifolia Vill.).

The hepatotoxic-protective effects of "San-fang-feng" (the root of E. grijisii) and "Lou-lu" (the root of E. latifolius) on CCl 4 induced hepatotoxicity have been proposed in our previous paper (Lin et al, 1990). The anti-inflammatory effects of these two crude drugs were investigated in this experiment. The results indicated that both of them displayed pronounced anti-inflammatory activities against carrageenan-induced edema. Furthermore, in order to isolated the main active components of E. grijisii, fractions obtained from the methanolic extract of E. grijisii were investigated in mice for their 24-h LD 50 and 95% confidence limits, which could be used as a guiding for further animal experiments. Our findings demonstrated that n-hexane (100,300 mg/kg), chloroform (30,100,300 mg/kg) and ethyl acetate (30,100, 300 mg/kg) fractions could markedly inhibit the carrageenan-induced inflammation, and the main active principle was found to be concentrated in the chloroform fraction, which possessed significant inhibitory activities even more than does indomethacin.

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The Anti-inflammatory Effects of Chinese Crude Drug Prescriptions on Experimental Arthritis

The American Journal of Chinese Medicine ◽

10.1142/s0192415x95000195 ◽

1995 ◽

Vol 23 (02) ◽

pp. 145-152 ◽

Cited By ~ 3

Author(s):

Chun-Ching Lin ◽

Ming-Feng Chen ◽

Chieh-Fu Chen

Keyword(s):

Chronic Arthritis ◽

Experimental Arthritis ◽

Drug Prescriptions ◽

Acute Arthritis ◽

Crude Drug ◽

Inflammatory Drugs ◽

Crude Drugs ◽

Freund’S Adjuvant ◽

Freund's Adjuvant ◽

Anti Inflammatory

San-Miao-Warn (SMW), Tuhwo-Jih-Shen-Tang (TJS) and Dang-Quei-Nian-Tong-Tang (DGT) are Chinese traditional prescriptions. In this study, we evaluated the anti-inflammatory activities of these crude drug prescriptions in carrageenan-induced acute arthritis and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. It was found that pretreatment with SMW, TJS or DGT at a dosage of 100 mg/kg or 300 mg/kg, significantly inhibited carrageenan-induced acute arthritis. Moreover, these crude drugs also significantly suppressed the development of chronic arthritis induced by CFA. These results suggest that SMW, TJS and DGT are potential anti-inflammatory agents and may be considered as alternatives for non-steroid anti-inflammatory drugs (NSAID).

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Anti-inflammatory effect of foods and crude drugs in relation to bitter and spicy tastes

Bioactive Compounds in Health and Disease ◽

10.31989/bchd.v2i4.613 ◽

2019 ◽

Vol 2 (4) ◽

pp. 77 ◽

Cited By ~ 1

Author(s):

Yukinobu Ikeya ◽

Denise A. Epp ◽

Mikio Nishizawa

Keyword(s):

Blood Stasis ◽

Earth Metal ◽

The Body ◽

Kampo Medicine ◽

Crude Drug ◽

Wood Fire ◽

Five Elements ◽

Crude Drugs ◽

Anti Inflammatory ◽

Pharmacological Function

Backround: In Kampo medicine as well as traditional Chinese medicine, each crude drug is classified by four properties (cold, cool, warm, and heat), five tastes (sour, bitter, sweet, spice, and salt) based on the Yin-yang and five elements (wood, fire, earth, metal, water) theory. The four properties and five tastes are greatly related to the medicinal efficacy of the crude drug in Kampo medicine. The pharmacological function of crude drugs is called "Yakuno" in Japanese. Examples of Yakuno include various functions such as clearing heat and removing blood stasis. Crude drugs with properties classified as cold or cool have the function to clear heat as they cool the body. Crude drugs classified as bBitter also have the function to clear heat. We speculated that anti-inflammatory constituents are included in crude drugs and food that are classified as cold or cool in property and bitter in taste.Keywords: crude drug, Kampo medicine, food, property, taste, nitric oxide, inflammation, pharmacological function

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Fundamental Research for the Pharmacological Activity of Oriental Drugs. IX. : On the Combined Action of Several Crude Drugs Consisting in "Rokusingan"for the Anti-inflammatory Effect

YAKUGAKU ZASSHI ◽

10.1248/yakushi1947.88.2_135 ◽

1968 ◽

Vol 88 (2) ◽

pp. 135-139 ◽

Cited By ~ 6

Author(s):

MASAYASU KIMURA ◽

EIZABURO OSADA ◽

TAKESHI MATSUI ◽

CHIYOKO KOBAYASHI

Keyword(s):

Pharmacological Activity ◽

Fundamental Research ◽

Combined Action ◽

Crude Drugs ◽

Anti Inflammatory ◽

Inflammatory Effect

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Anti-inflammatory Constituents of Topically Applied Crude Drugs. V. Constituents and Anti-inflammatory Effect of Aoki, Aucuba japonica THUNB.

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.17.665 ◽

1994 ◽

Vol 17 (5) ◽

pp. 665-667 ◽

Cited By ~ 22

Author(s):

Mineo SHIMIZU ◽

Takashi TOMOO

Keyword(s):

Aucuba Japonica ◽

Crude Drugs ◽

Anti Inflammatory ◽

Inflammatory Effect

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Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000620 ◽

2019 ◽

pp. 1-9

Author(s):

Samira Salem ◽

Essaid Leghouchi ◽

Rachid Soulimani ◽

Jaouad Bouayed

Keyword(s):

Time Course ◽

Acute Inflammation ◽

Lichen Species ◽

Paw Edema ◽

Sod Activity ◽

Edema Formation ◽

Lobaria Pulmonaria ◽

Anti Inflammatory ◽

Endogenous Antioxidant ◽

Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

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