scholarly journals Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed I. Optimum Formulation for Core Particles and Development of a Novel Friability Test Method

2007 ◽  
Vol 55 (8) ◽  
pp. 1169-1174 ◽  
Author(s):  
Tomohiro Hamashita ◽  
Yasuo Nakagawa ◽  
Takao Aketo ◽  
Satoru Watano
Keyword(s):  
Fluidized Bed ◽  
Film Coating ◽  
Test Method ◽  
Optimum Formulation ◽  
Core Particles

scholarly journals Preparation of Core Particles for Aqueous Film Coating Using Agitation Fluidized Bed.

1997 ◽  
Vol 45 (12) ◽  
pp. 2039-2042 ◽  
Author(s):  
Satoru WATANO ◽  
Kengo ANDO ◽  
Kei MIYANAMI ◽  
Yoshinori II ◽  
Seiei SASATANI
Keyword(s):  
Fluidized Bed ◽  
Film Coating ◽  
Core Particles

scholarly journals Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed II. A Proposal of a Rapid Dissolution Test for Evaluation of Bitter Taste of Ibuprofen

2008 ◽  
Vol 56 (7) ◽  
pp. 883-887 ◽  
Author(s):  
Tomohiro Hamashita ◽  
Miwako Matsuzaki ◽  
Tetsuo Ono ◽  
Masaki Ono ◽  
Yoshinobu Tsunenari ◽  
...  
Keyword(s):  
Fluidized Bed ◽  
Bitter Taste ◽  
Film Coating ◽  
Dissolution Test ◽  
Rapid Dissolution ◽  
Core Particles

Quantitative Analysis of Film Coating in a Fluidized Bed Process by In-Line NIR Spectrometry and Multivariate Batch Calibration

2000 ◽  
Vol 72 (9) ◽  
pp. 2099-2108 ◽  
Author(s):  
Martin Andersson ◽  
Staffan Folestad ◽  
Johan Gottfries ◽  
Mats O. Johansson ◽  
Mats Josefson ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Fluidized Bed ◽  
Film Coating ◽  
Fluidized Bed Process

scholarly journals Preparation of Core Particles with High Drug Content from Slurry Materials using a Direct Granulation Method with a Fluidized Bed Granulator.

2000 ◽  
Vol 37 (2) ◽  
pp. 107-114 ◽  
Author(s):  
Hiroyuki TSUJIMOTO ◽  
Kazunori NAGATA ◽  
Toyokazu YOKOYAMA ◽  
Takayuki KAMATA ◽  
Keijirou TERASHITA ◽  
...  
Keyword(s):  
Fluidized Bed ◽  
High Drug ◽  
Drug Content ◽  
Core Particles

scholarly journals Piecewise function parameters as responses of the design of experiment in the development of a pulsatile release chronopharmaceutical system

2016 ◽  
Vol 66 (2) ◽  
pp. 173-189 ◽  
Author(s):  
Andreea Loredana Vonica-Gligor ◽  
Ioan Tomuţă ◽  
Sorin E. Leucuţa
Keyword(s):  
Drug Release ◽  
Design Of Experiment ◽  
Film Coating ◽  
Dissolution Profile ◽  
Box Behnken Design ◽  
Pulsatile Release ◽  
Swelling Agent ◽  
Piecewise Function ◽  
Optimum Formulation ◽  
Sigmoid Shape

Abstract The aim of this work was to develop a pulsatile release system with metoprolol for chronotherapeutical use by coating swellable mini-tablets with Eudragit RS. To study the influence of the formulation factors (amount of coating polymer, plasticizer percentage in film coating and swelling agent percentage in mini-tablets), a Box-Behnken design of experiment (DoE) was used. To evaluate the influence of the studied factors on the sigmoid shape of the dissolution profile, piecewise function parameters were used as the responses of DoE. The results show that higher concentrations of coating polymer and higher concentrations of plasticizer polymer led to a thicker and more elastic polymeric film, which led to a delay in drug release. Using the parameters of the piecewise function as DoE responses, an optimum formulation with a sigmoid shape dissolution profile and a 2.5-h lag time followed by rapid drug release were obtained.

Sign in / Sign up

Export Citation Format

Share Document