scholarly journals Antioxidant and Anti-inflammatory Related Activities of Selected Synthetic Chalcones: Structure–Activity Relationship Studies Using Computational Tools

2008 ◽  
Vol 56 (7) ◽  
pp. 897-901 ◽  
Author(s):  
Rajesh Gacche ◽  
Mansi Khsirsagar ◽  
Srikant Kamble ◽  
Babasaheb Bandgar ◽  
Nagesh Dhole ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Computational Tools ◽  
Structure Activity ◽  
Anti Inflammatory

Flavones induce immunomodulatory and anti-inflammatory effects by activating cellular anti-oxidant activity: a structure-activity relationship study

Tumor Biology ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 6571-6579 ◽  
Author(s):  
Soumaya Kilani-Jaziri ◽  
Nadia Mustapha ◽  
Imen Mokdad-Bzeouich ◽  
Dorra El Gueder ◽  
Kamel Ghedira ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Anti Oxidant ◽  
Relationship Study ◽  
Anti Inflammatory

Tiliroside: Biosynthesis, Bioactivity and Structure activity relationship (SAR)- A review

2017 ◽  
Vol 6 (6) ◽  
pp. 343-348
Author(s):  
Lokadi Pierre Luhata ◽  
◽  
Wembi Gaston Luhata ◽  
◽  
Keyword(s):  
Acute Inflammation ◽  
Shikimate Pathway ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Coumaric Acid ◽  
Acid Moiety ◽  
Structure Activity ◽  
Starter Unit ◽  
Anti Inflammatory ◽  
Relationship Of

Tilirosides (TLD) are glycosidic flavonoids (GFD) from originating in plants that exhibit a range of bioactivities of great interest for healthcare: antioxidant, anti-microbial, antifungal, anti-diabetic and antihyperlipedemic, antiviral and cytotoxic, anti–inflammatory, anti-rheumatism, inhibition of neuroinflammation and acute inflammation and hepatoprotective activities. TLD are biosynthesized in plants in three main steps. First, the synthesis of the aglycone (a flavonoid) occurs, which follows the shikimate pathway with cinnamoylCoA as a starter unit. Second, there is the glucosylation of the aglycone using Uridine diphosphosugar (UDPglucose) as the agent for glycosylation. Finally, the coumaroyl part is added. The Structure Activity Relationship of TLD reveals that the addition of the para coumaric acid moiety considerably modifies their bioactivity.

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