scholarly journals Cytotoxicity of Organochlorine Pesticides and Lipid Peroxidation in Rat Hepatocytes (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)

Eisei kagaku ◽  
1997 ◽  
Vol 43 (1) ◽  
pp. P5-P5
Author(s):  
Toshihide SUZUKI ◽  
Miho KOMATSU ◽  
Hideo ISONO
Keyword(s):  
Lipid Peroxidation ◽  
Environmental Health ◽  
Organochlorine Pesticides ◽  
Rat Hepatocytes

Effects of Deoxycholic Acid and Its Epimers on Lipid Peroxidation in Isolated Rat Hepatocytes

2001 ◽  
Vol 129 (5) ◽  
pp. 683-689 ◽  
Author(s):  
A. Hino ◽  
M. Morita ◽  
M. Une ◽  
K. Fujimura ◽  
T. Kuramoto
Keyword(s):  
Lipid Peroxidation ◽  
Deoxycholic Acid ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

scholarly journals Asiatic Acid Derivatives Protect Primary Cultures of Rat Hepatocytes against Carbon Tetrachloride-Induced Injury via the Cellular Antioxidant System

2009 ◽  
Vol 4 (6) ◽  
pp. 1934578X0900400
Author(s):  
Mi Kyeong Lee ◽  
Seung Hyun Kim ◽  
Hyekyung Yang ◽  
Doo-Yeon Lim ◽  
Je-Ho Ryu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Carbon Tetrachloride ◽  
Primary Cultures ◽  
Rat Hepatocytes ◽  
Asiatic Acid ◽  
Antioxidative Defense ◽  
Protective Activity ◽  
Defense System

We attempted to elucidate the hepatoprotective mechanism of two asiatic acid (AS) derivatives, 3β,23-dihydroxyurs-2-oxo-12-ene-28-oic acid (AS-10) and 3β,23-dihydroxyurs-12-ene-28-oic acid (AS-14), which exhibited significant protective activity against carbon tetrachloride (CCl4)-induced hepatotoxicity in primary cultures of rat hepatocytes. Our findings showed that AS-10 and AS-14 preserved the level of glutathione and the activities of antioxidant enzymes such as glutathione reductase, glutathione peroxidase, superoxide dismutase and catalase. In addition, these compounds ameliorated lipid peroxidation, as demonstrated by a reduction in the production of malondialdehyde. Furthermore, AS-10 and AS-14 did not restore the reduced total GSH level by BSO, indicating that the hepatoprotective activities of these compounds may be involved, in part, by regulating GSH synthesis. From these results, we suggest that both AS-10 and AS-14 exerted their hepatoprotective activities against CCl4-induced injury by preserving the cellular antioxidative defense system.

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