scholarly journals Subacute Pulmonary Hypertension due to Pulmonary Tumor Microembolism as a Clinical Manifestation of Occult Gallbladder Adenocarcinoma

1997 ◽  
Vol 61 (1) ◽  
pp. 82-86 ◽  
Author(s):  
Hironobu Ando ◽  
Yoshiaki Ootake ◽  
Shosaku Asaka
Keyword(s):  
Pulmonary Hypertension ◽  
Clinical Manifestation ◽  
Pulmonary Tumor ◽  
Gallbladder Adenocarcinoma

scholarly journals Pulmonary Tumor Thrombotic Microangiopathy as a Cause of Pulmonary Hypertension

2021 ◽  
Vol 3 (7) ◽  
pp. 1029-1031
Author(s):  
Benjamin P. Schwartz ◽  
Philip Tracy ◽  
Stephanie Hon ◽  
Harrison W. Farber ◽  
James E. Udelson
Keyword(s):  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Pulmonary Tumor ◽  
Pulmonary Tumor Thrombotic Microangiopathy

scholarly journals Signet Ring Cell Carcinoma of Unknown Primary Complicated with Pulmonary Tumor Thrombotic Microangiopathy and Krukenberg Tumor

2018 ◽  
Vol 11 (2) ◽  
pp. 412-417
Author(s):  
Masahide Tanaka ◽  
Koichiro Takahashi ◽  
Yuki Kurihara ◽  
Mihoko Yamamoto-Rikitake ◽  
Shinsuke Ogusu ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Krukenberg Tumor ◽  
Carcinoma Of Unknown Primary ◽  
Pulmonary Tumor ◽  
Signet Ring ◽  
Ring Cell

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare disease that shows hypoxia with severe pulmonary hypertension related to malignant tumor. Diagnosis is difficult due to rapid clinical progression and the need to demonstrate pathological findings from lung biopsy. A 64-year-old woman visited our hospital with hypoxia and pulmonary hypertension. Diffuse granular shadows in the centrilobular area and ground-glass shadows in both lungs and left ovarian tumor were found on radiological imaging. PTTM was suspected, but pulmonary artery blood aspiration by right cardiac catheter failed to detect cancer cells. We could not obtain lung or ovary biopsies because of hypoxia or pulmonary hypertension. The patient died due to respiratory failure. Signet ring cell carcinoma of unknown primary, PTTM, and Krukenberg tumor were diagnosed on autopsy. Since early diagnosis facilitates adequate treatment, physicians should not miss the opportunity for biopsy in cases of suspected PTTM.

scholarly journals Pulmonary Hypertension Caused by Lung Cancer Suspected to Have Pulmonary Tumor Thrombotic Microangiopathy and Which We Treated with Gefitinib

Haigan ◽  
2012 ◽  
Vol 52 (4) ◽  
pp. 420-425 ◽  
Author(s):  
Kiyokazu Yoshinoya ◽  
Yu Kasamatsu ◽  
Shougen Boku ◽  
Takashi Kida ◽  
Masatoshi Kadoya ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Pulmonary Tumor ◽  
Pulmonary Tumor Thrombotic Microangiopathy

scholarly journals Pulmonary tumor thrombotic microangiopathy presenting as recurrent syncope

2020 ◽  
Vol 8 ◽  
pp. 2050313X2096904
Author(s):  
Constanza Burciaga Calderoni ◽  
Dafne T Moretta ◽  
Jeanette Merrill-Henry ◽  
Paresh C Giri
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Rare Condition ◽  
Right Heart Failure ◽  
Coagulation Cascade ◽  
Right Heart ◽  
Rare Presentation ◽  
Pulmonary Tumor ◽  
Pulmonary Tumor Thrombotic Microangiopathy

Pulmonary tumor thrombotic microangiopathy is a rare condition in which embolization of tumor cells to the pulmonary arterioles causes fibrocellular intimal thickening and activation of the coagulation cascade resulting in pulmonary hypertension and right heart failure. Herein, we highlight a young 35-year-old male with no known past medical history who presented with recurrent syncope and dyspnea, and was found to have severe right heart failure and pulmonary hypertension. He developed sudden clinical deterioration and died after a cardiac arrest. Autopsy revealed poorly differentiated gastric adenocarcinoma and pulmonary tumor thrombotic microangiopathy. New onset severe pulmonary hypertension and right heart failure without any other obvious etiology should encourage the reader to evaluate for pulmonary tumor thrombotic microangiopathy and undergo a diligent search for underlying malignancy. This case highlights recurrent syncope as a rare presentation of this rapidly fatal disease.

scholarly journals THE CLINICAL FEATURES OF ATRIOVENTRICULAR CANAL DEFECT

2017 ◽  
Vol 2 ◽  
pp. 14-21
Author(s):  
Andriana Malska
Keyword(s):  
Pulmonary Hypertension ◽  
Clinical Features ◽  
Clinical Manifestation ◽  
Congenital Heart ◽  
Viral Infections ◽  
Heart Defects ◽  
Mitral Valve Insufficiency ◽  
Atrioventricular Canal ◽  
Atrioventricular Canal Defect ◽  
Sternal Border

Atrioventricular canal defect (AVCD) is a congenital heart defect, which occurs in 2.9 % of all congenital heart defects (CHD) and is characterized by a wide variety of anatomical forms and often don’t have clear cardiac manifestation. Untreated AVCD may lead to the development of pulmonary hypertension. Aim. To determine clinical features of AVCD in children, considering variable anatomical forms of the pathology and its association with genetic pathology. Materials and methods. Patients history and outpatient statistic records of children with AVCD, who were admitted to Lviv Regional Children’s Hospital from September 1999 till January 2016 have been analyzed (n=84). The aspects of clinical manifestation of AVCD without associated pathology have been identified (n=48). Clinical manifestation of complete (n=36) and incomplete (n=12) AVCD and clinical manifestation with and without Down syndrome have been discussed. Children with AVCD were divided into two groups: A – children with complete (n=36) and B – with incomplete (n=12) form of AVCD. Group A was divided into A1 – with trisomy 21 (n=14), A2 – without genetic pathology (n=22). Results. In group А2 – 36,36±10,26 % and in group В – 50±14,4 % children were asymptomatic. Dyspnea, increased sweating during feeds, growth retardation and frequent respiratory viral infections during early childhood period were leading symptoms. Most frequent auscultation findings were accent of II heart sound over the pulmonary artery and 2-3/6 systolic murmur over left sternal border. According to echocardiographic examination mitral valve insufficiency was predominantly of mild grade, tricuspid insufficiency and pulmonary hypertension was diagnosed in group А2 with the frequency of 9,09±6,13 %). Conclusions: The absence of clinical features in group A2 and B 36,36±10,26 and 50,00±14,40 respectively, saturation levels 92,36±0,49 % in patients without genetic pathology and 95,25±0,40 % with incomplete AVCD provide a need to adopt protocol of children examination with saturation level under 95 % and compulsory echocardiographic diagnosis within the first month of life

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