scholarly journals Correlation between inhibition of renin-angiotensin system and antihypertensive effect of MK-421 and captopril in 2-kidney, 1-clip renal hypertensive rats after a single and repeated oral administration of MK-421 or captopril.

1985 ◽  
Vol 86 (4) ◽  
pp. 303-313 ◽  
Author(s):  
Ippei OHMURA ◽  
Eiji MAKI ◽  
Tomohiro NARUSE ◽  
Noriji IKEDA ◽  
Terumi ASAMI ◽  
...  
Keyword(s):  
Oral Administration ◽  
Antihypertensive Effect ◽  
Renin Angiotensin System ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Renal Hypertensive Rats

scholarly journals Regulation of brain renin-angiotensin system by benzamil-blockable sodium channels

1999 ◽  
Vol 276 (5) ◽  
pp. R1416-R1424 ◽  
Author(s):  
Masato Nishimura ◽  
Ken Ohtsuka ◽  
Naoharu Iwai ◽  
Hakuo Takahashi ◽  
Manabu Yoshimura
Keyword(s):  
Sodium Channels ◽  
Renin Angiotensin System ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Intracerebroventricular Infusion ◽  
Pcr Method ◽  
The Brain ◽  
Renal Hypertensive Rats

Changes in the renin-angiotensin system (RAS) mRNAs in the brain and the kidney of rats after administration of DOCA and/or sodium chloride were assessed by use of a competitive PCR method. Benzamil, a blocker of amiloride-sensitive sodium channels, was infused intracerebroventricularly or intravenously for 7 days in DOCA-salt or renal hypertensive rats, and the effects of benzamil on the brain RAS mRNAs were determined. Renin and ANG I-converting enzyme (ACE) mRNAs were not downregulated in the brain of rats administered DOCA and/or salt; however, these mRNAs were decreased in the kidney. Intracerebroventricular infusion of benzamil decreased renin, ACE, and ANG II type 1 receptor mRNAs in the brain of DOCA-salt hypertensive rats but not in the brain of renal hypertensive rats. The gene expression of the brain RAS, particularly renin and ACE, is regulated differently between the brain and the kidney in DOCA-salt hypertensive rats, and benzamil-blockable brain sodium channels may participate in the regulation of the brain RAS mRNAs.

Does the Renin—Angiotensin System Contribute to the Vascular Lesions in Renal Hypertensive Rats?

1976 ◽  
Vol 51 (s3) ◽  
pp. 33s-35s
Author(s):  
R. Dietz ◽  
H. Haebara ◽  
B. Lüth ◽  
G. Mast ◽  
Z. Nemes ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
Vascular Wall ◽  
Vascular Lesions ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Spontaneously Hypertensive ◽  
Renin Angiotensin ◽  
High Sodium ◽  
High Sodium Diet ◽  
Renal Hypertensive Rats

1. Renal hypertensive rats with a normal or suppressed activity of the renin—angiotensin system develop vascular lesions which are similar to those observed in spontaneously hypertensive rats on high sodium diet. 2. Exposure of a vascular bed to high blood pressure results in a rapid damage of the vascular wall, irrespective of the state of the renin—angiotensin system.

scholarly journals Role of renin-angiotensin system in chronic renal hypertensive rats.

Hypertension ◽  
1979 ◽  
Vol 1 (4) ◽  
pp. 427-434 ◽  
Author(s):  
S Sen ◽  
R R Smeby ◽  
F M Bumpus ◽  
J G Turcotte
Keyword(s):  
Renin Angiotensin System ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Renal Hypertensive Rats

Role of Prostaglandins on the Renin-Angiotensin System in Normotensive and Hypertensive Rats

1996 ◽  
Vol 26 (2) ◽  
pp. 553
Author(s):  
Pyung-Jin Yoon ◽  
Mann Jung ◽  
Jong-Seung Kim ◽  
Jae-Yeoul Jun ◽  
Cheol-Ho Yeum
Keyword(s):  
Renin Angiotensin System ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Renin Angiotensin
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