scholarly journals Distinct role of dopamine in the PFC and NAc in retrieval of cocaine reward memory

2021 ◽  
Vol 94 (0) ◽  
pp. 2-P1-01
Author(s):  
Yukie Kawahara ◽  
Yoshinori Ohnishi ◽  
Yoko Ohnishi ◽  
Hiroshi Kawahara ◽  
Akinori Nishi
Keyword(s):  
Distinct Role ◽  
Cocaine Reward

scholarly journals F4/80+ Kupffer Cell-Derived Oncostatin M Sustains the Progression Phase of Liver Regeneration through Inhibition of TGF-β2 Pathway

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2231
Author(s):  
Qingjun Lu ◽  
Hao Shen ◽  
Han Yu ◽  
Jing Fu ◽  
Hui Dong ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Serum Levels ◽  
Inhibitory Effect ◽  
Regenerative Process ◽  
Oncostatin M ◽  
Hepatocyte Proliferation ◽  
Initiation Phase ◽  
Distinct Role

The role of Kupffer cells (KCs) in liver regeneration is complicated and controversial. To investigate the distinct role of F4/80+ KCs at the different stages of the regeneration process, two-thirds partial hepatectomy (PHx) was performed in mice to induce physiological liver regeneration. In pre- or post-PHx, the clearance of KCs by intraperitoneal injection of the anti-F4/80 antibody (α-F4/80) was performed to study the distinct role of F4/80+ KCs during the regenerative process. In RNA sequencing of isolated F4/80+ KCs, the initiation phase was compared with the progression phase. Immunohistochemistry and immunofluorescence staining of Ki67, HNF-4α, CD-31, and F4/80 and Western blot of the TGF-β2 pathway were performed. Depletion of F4/80+ KCs in pre-PHx delayed the peak of hepatocyte proliferation from 48 h to 120 h, whereas depletion in post-PHx unexpectedly led to persistent inhibition of hepatocyte proliferation, indicating the distinct role of F4/80+ KCs in the initiation and progression phases of liver regeneration. F4/80+ KC depletion in post-PHx could significantly increase TGF-β2 serum levels, while TGF-βRI partially rescued the impaired proliferation of hepatocytes. Additionally, F4/80+ KC depletion in post-PHx significantly lowered the expression of oncostatin M (OSM), a key downstream mediator of interleukin-6, which is required for hepatocyte proliferation during liver regeneration. In vivo, recombinant OSM (r-OSM) treatment alleviated the inhibitory effect of α-F4/80 on the regenerative progression. Collectively, F4/80+ KCs release OSM to inhibit TGF-β2 activation, sustaining hepatocyte proliferation by releasing a proliferative brake.

scholarly journals Distribution and function of carbamate hydrolase genes cehA and mcd in soils: the distinct role of soil pH

2018 ◽  
Vol 94 (6) ◽  
Author(s):  
Constantina Rousidou ◽  
Dionysis Karaiskos ◽  
Despoina Myti ◽  
Evangelos Karanasios ◽  
Panagiotis A Karas ◽  
...  
Keyword(s):  
Soil Ph ◽  
And Function ◽  
Distinct Role

Distinct role of insulin and IGF-I and its receptors in white skeletal muscle during the compensatory growth of gilthead sea bream (Sparus aurata)

Aquaculture ◽  
2007 ◽  
Vol 267 (1-4) ◽  
pp. 188-198 ◽  
Author(s):  
Núria Montserrat ◽  
Pedro Gómez-Requeni ◽  
Giovanni Bellini ◽  
Encarnación Capilla ◽  
Jaume Pérez-Sánchez ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Compensatory Growth ◽  
Sparus Aurata ◽  
Gilthead Sea Bream ◽  
Sea Bream ◽  
Igf I ◽  
Distinct Role

Distinct role of adiposity and insulin resistance in glucose intolerance: Studies in ventromedial hypothalamic-lesioned obese rats

Metabolism ◽  
2002 ◽  
Vol 51 (6) ◽  
pp. 716-723 ◽  
Author(s):  
Asako Kageyama ◽  
Tsutomu Hirano ◽  
Haruaki Kageyama ◽  
Toshimasa Osaka ◽  
Yoshio Namba ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Intolerance ◽  
Obese Rats ◽  
Distinct Role

scholarly journals Evolutionary Algorithms for Boolean Functions in Diverse Domains of Cryptography

2016 ◽  
Vol 24 (4) ◽  
pp. 667-694 ◽  
Author(s):  
Stjepan Picek ◽  
Claude Carlet ◽  
Sylvain Guilley ◽  
Julian F. Miller ◽  
Domagoj Jakobovic
Keyword(s):  
Evolutionary Algorithms ◽  
Genetic Programming ◽  
Evolutionary Computation ◽  
Boolean Functions ◽  
Coding Theory ◽  
Design Criteria ◽  
Hamming Weight ◽  
High Quality ◽  
Distinct Role

The role of Boolean functions is prominent in several areas including cryptography, sequences, and coding theory. Therefore, various methods for the construction of Boolean functions with desired properties are of direct interest. New motivations on the role of Boolean functions in cryptography with attendant new properties have emerged over the years. There are still many combinations of design criteria left unexplored and in this matter evolutionary computation can play a distinct role. This article concentrates on two scenarios for the use of Boolean functions in cryptography. The first uses Boolean functions as the source of the nonlinearity in filter and combiner generators. Although relatively well explored using evolutionary algorithms, it still presents an interesting goal in terms of the practical sizes of Boolean functions. The second scenario appeared rather recently where the objective is to find Boolean functions that have various orders of the correlation immunity and minimal Hamming weight. In both these scenarios we see that evolutionary algorithms are able to find high-quality solutions where genetic programming performs the best.

Rejection despite C5 blockade: a distinct role of IgM?

2014 ◽  
Vol 27 (12) ◽  
pp. 1233-1234 ◽  
Author(s):  
Georg A. Böhmig ◽  
Farsad Eskandary
Keyword(s):  
Distinct Role

Abstract 13483: Pathological Decline in Incretin Hormone Glucagon-like Peptide-1 Causes Cardiac Apoptosis and Dysfunction in Pressure-overloaded Heart Failure Through Cyclic AMP-dependent Mechanisms. -Distinct Role of Protein Kinase a and EPAC

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Morihiko Aoyama ◽  
Yasuko K Bando ◽  
Haruya Kawase ◽  
Akio Monji ◽  
Toko Mitsui ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cyclic Amp ◽  
Left Ventricular ◽  
Ample Evidence ◽  
Incretin Hormone ◽  
Myocardial Apoptosis ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Distinct Role

Introduction: Ample evidence demonstrates cardiovascular protection by incretin hormone glucagon-like peptide-1 (GLP-1) through the cyclic AMP axis. GLP-1 is known for its inotropic effect on heart, however, the role of GLP-1 in heart failure remains uncertain. Hypothesis: To explore the pathophysiological role of GLP-1 in heart failure Methods: Pressure overload-induced heart failure model was generated by transverse aortic constriction in mice (TAC). Results: At 4 week after the operation, TAC exhibited systolic left-ventricular dysfunction, myocardial hypertrophy and augmented apoptosis. Unexpectedly, circulating GLP-1 concentration was markedly decreased in TAC (in pM; 0.86±0.10 for TAC versus 2.13±0.54 for sham) with concomitant reduction of myocardial cyclic AMP concentration (in pmole/mg protein; 33.0±1.4 for TAC versus 42.2±1.5). TAC exhibited pathological changes in signaling molecules of myocardial contractility [SERCA, phospho-phospholamban(Serine16; pPL), β-myosin heavy chain (MYH7)], remodeling (Akt/mTOR/S6K), and cell death markers (procaspase-3/Bcl2 for apoptosis and PINK/PARKIN complex for mitophagy detecting damaged mitochondria). All of these changes observed in TAC heart were reversed selectively by treatment with GLP-1 analog exendin-4 (Ex4; 24nmole/kg/day for 4 weeks) and indirect supplement of GLP-1 by a DPP4 inhibitor alogliptin (ALO; 10mg/kg/day for 4 weeks). In vitro TUNEL assay using cultured cardiomyocytes revealed that Ex-4 reduced myocardial apoptosis in a cAMP/EPAC1-dependent but PKA-independent manner (Figure). Conclusions: Pressure-overloaded heart failure exhibits decline in GLP-1, leading to cAMP/EPAC1-dependent impairment in myocardial apoptosis, and cAMP/PKA/pPL/SERCA-dependent myocardial contractile dysfunction. Our data suggest the distinct role of PKA and EPAC in pathophysiology underlying heart failure.

Creating Revolutionary Justice

2020 ◽  
pp. 22-59
Author(s):  
Matthew Rendle
Keyword(s):  
Civil War ◽  
Legal Reform ◽  
Secret Police ◽  
Clear Sense ◽  
New System ◽  
Distinct Role

The first chapter provides the foundation for the rest of the book by charting the establishment of revolutionary justice. Although the Bolsheviks had a clear sense of the role of law in society and a clear desire to oversee legal reform, they did not have a coherent plan on exactly what they would do. Consequently, the new system emerged steadily through the year after October with the development of tribunals shaped by the Bolsheviks’ experiences of early trials and the intensifying civil war. This chapter examines the decrees that outlined the official role of tribunals, explores the experiences of the early trials, and looks at how tribunals started to operate in practice, both nationally and locally. It examines various reforms of the tribunal system and various types of tribunals, including press tribunals, provincial tribunals, and the Supreme Tribunal. From the start, tribunals were pitted against the secret police, the Cheka, and this too shaped how tribunals took shape. By late 1918, however, tribunals were firmly in place, with a structure that only changed minimally thereafter and a distinct role alongside the Cheka.

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