Follicular dendritic cell sarcoma arising from the hypopharynx

Follicular dendritic cell (FDC) tumours have been described recently as malignant tumours arising from accessory cells of the lymph nodes. They are rare tumours with fewer than 70 cases occurring worldwide. They usually present in cervical or abdominal lymph nodes,with very few occurring extranodally. We present the first case of an FDC tumour to occur in the hypopharynx with simultaneous cervical node metastases. The pathology is discussed and the literature reviewed.

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Follicular dendritic cell sarcoma presenting as a thyroid mass: an unusual case report and literature review

Journal of International Medical Research ◽

10.1177/0300060520920433 ◽

2020 ◽

Vol 48 (6) ◽

pp. 030006052092043

Author(s):

Ting Zhang ◽

Liang He ◽

Zhihong Wang ◽

Wenwu Dong ◽

Wei Sun ◽

...

Keyword(s):

Case Report ◽

Dendritic Cell ◽

Radical Neck Dissection ◽

Follicular Dendritic Cell ◽

Follicular Dendritic Cell Sarcoma ◽

Cell Sarcoma ◽

Dendritic Cell Sarcoma ◽

First Case ◽

Follicular Dendritic ◽

Rare Malignancy

Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the germinal centers and is characterized by the neoplastic proliferation of spindled to ovoid cells. As there have been only five cases reported in the literature until now, the diagnostic and therapeutic information available to clinicians regarding thyroid FDCS is fairly limited. To our knowledge, this is the first case report of thyroid FDCS without a history of Hashimoto’s thyroiditis. A 48-year-old woman was found to have a slow-growing mass in the left thyroid. After total thyroidectomy and left modified radical neck dissection, the specimen demonstrated morphologic and immunohistochemical features of FDCS. The patient had a favorable prognosis with no evidence of disease 11 months after tumor excision.

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Primary follicular dendritic cell sarcoma of the urinary bladder: the first case report and potential diagnostic pitfalls

Diagnostic Pathology ◽

10.1186/s13000-017-0625-4 ◽

2017 ◽

Vol 12 (1) ◽

Cited By ~ 5

Author(s):

Guang-Jie Duan ◽

You-Li Wu ◽

Hui Sun ◽

Lang Lang ◽

Zhi-Wen Chen ◽

...

Keyword(s):

Case Report ◽

Dendritic Cell ◽

Urinary Bladder ◽

Follicular Dendritic Cell ◽

Follicular Dendritic Cell Sarcoma ◽

Cell Sarcoma ◽

Dendritic Cell Sarcoma ◽

First Case ◽

Follicular Dendritic ◽

Diagnostic Pitfalls

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Follicular Dendritic Cell Sarcoma Arising in the Dura Mater of the Spine

Archives of Pathology & Laboratory Medicine ◽

10.5858/2006-130-1718-fdcsai ◽

2006 ◽

Vol 130 (11) ◽

pp. 1718-1721 ◽

Cited By ~ 2

Author(s):

Jung Woo Choi ◽

Ju-Han Lee ◽

Aeree Kim ◽

Chul Hwan Kim ◽

Yang Seok Chae ◽

...

Keyword(s):

Dendritic Cell ◽

Dura Mater ◽

Case Reports ◽

Follicular Dendritic Cell ◽

Individual Case ◽

Follicular Dendritic Cell Sarcoma ◽

Cell Sarcoma ◽

Dendritic Cell Sarcoma ◽

First Case ◽

Follicular Dendritic

Abstract There have been some individual case reports and a few large series of reports describing the clinicopathologic features of follicular dendritic cell sarcoma. This tumor originates from the dendritic cells of lymphoid follicles and is extremely rare in the extranodal location. We report the case of a 68-year-old man who presented with low back pain. A mass was found in the lumbar dura mater and extended to the right epidural space. The tumor was composed of nodules, sheets, and interlacing fascicles of oval-to-spindle cells intermingled with the dense infiltrates of small lymphocytes. Immunohistochemical staining revealed that the tumor cells were positive for CD21, CD23, CD35, and clusterin, and focally positive for CD68, CD20, and CD79a. To our knowledge, this is the first case of follicular dendritic cell sarcoma occurring in the dura mater of the spine.

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