Cervical cytology screening in HIV-positive women: completion of the audit cycle

Background: The relationship among HIV, HPV, and development of CIN is complex and incompletely understood. Present study is undertaken to find out the prevalence and relationship of abnormal cervical cytology and HPV infection in HIV positive women.Methods: This was a cross-sectional, case control study conducted on 95 HIV seropositive and 95 seronegative women. Specimen was collected from the cervix for HPV DNA testing, subtyping and cytology.Results: HPV DNA positivity was higher in seropositive group (18.6% vs. 7.4%). Premalignant conditions were found only in seropositive group. At CD4 count <249 HPV DNA positivity was 53%, at 250-499 the percentage of HPV DNA positivity was 31% and at >500 HPV DNA positivity was 19%.Conclusions: Prevalence of abnormal cytology and HPV DNA positivity is higher amongst HIV positive women and there is an association between HPV DNA positivity with lower CD4 counts.

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Comparison of the performance of anal cytology and cervical cytology as screening tests

Sexual Health ◽

10.1071/sh11178 ◽

2012 ◽

Vol 9 (6) ◽

pp. 568 ◽

Cited By ~ 21

Author(s):

Jennifer Margaret Roberts ◽

Julia Kathleen Thurloe

Keyword(s):

Cervical Screening ◽

Cervical Cytology ◽

Screening Tests ◽

Hiv Positive ◽

Anal Squamous Cell Carcinoma ◽

Target Populations ◽

Anal Cytology ◽

Sex With Men ◽

The Impact ◽

Cytology Screening

Cervical cytology screening has a long history and has successfully reduced the impact of cervical cancer in many countries. Anal cytology is a relative newcomer and anal screening is currently offered in only a few centres around the world. Many questions need to be answered before anal screening is more widely adopted. While there are many similarities between cervical and anal squamous cell carcinoma, there are also important differences: differences in the prevalence of disease, in the ‘at-risk’ target populations and possibly in the robustness of the reference standard of biopsy. The performance of cytology as a screening test in the literature varies widely but it is essential to understand that some of this variability is due to differences in the definitions of key parameters in the various studies. For cervical screening, estimates of sensitivity have ranged from 19% to 94% and specificity from 94% to 98%. For anal screening, data are fewer and more limited. Estimates of the sensitivity of anal cytology in men who have sex with men and HIV-positive populations have ranged from 55% to 87% and specificity from 37% to 76%. Ultimately, rather than comparing anal with cervical cytology, it may be more helpful to assess the value of anal cytology independently through well designed trials.

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Human Papillomavirus Co-Testing Results Effectively Triage Normal Cervical Cytology in HIV-Positive Women Aged 30 Years and Older

Journal of Lower Genital Tract Disease ◽

10.1097/lgt.0000000000000304 ◽

2017 ◽

Vol 21 (2) ◽

pp. 125-128 ◽

Cited By ~ 1

Author(s):

Rachel O. Alade ◽

Olivera Vragovic ◽

Conor Duffy ◽

Howard J. Cabral ◽

Elizabeth A. Stier

Keyword(s):

Human Papillomavirus ◽

Cervical Cytology ◽

Hiv Positive ◽

Hiv Positive Women ◽

Normal Cervical Cytology

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Cervical and Anal Cytology Screening in HIV-Positive Women Over Age 65 [10F]

Obstetrics and Gynecology ◽

10.1097/01.aog.0000483865.19861.f2 ◽

2016 ◽

Vol 127 ◽

pp. 53S

Author(s):

Alexandra Aserlind ◽

Karla Maguire ◽

Stefan Wennin ◽

Alec Szlachta-Mcginn ◽

Dana Senderoff ◽

...

Keyword(s):

Hiv Positive ◽

Hiv Positive Women ◽

Anal Cytology ◽

Cytology Screening

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Abnormal cervical cytology amongst women infected with human immunodeficiency virus in Limpopo province, South Africa

African Journal of Primary Health Care & Family Medicine ◽

10.4102/phcfm.v12i1.2215 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Samuel T. Ntuli ◽

Eric Maimela ◽

Linda Skaal ◽

Mabina Mogale ◽

Provia Lekota

Keyword(s):

South Africa ◽

Cervical Cancer ◽

Human Immunodeficiency Virus ◽

Limpopo Province ◽

Cervical Cytology ◽

Hiv Positive ◽

Abnormal Cytology ◽

Abnormal Cervical Cytology ◽

Hiv Positive Women ◽

Immunodeficiency Virus

Background: Cervical cancer remains the major public problem worldwide and the most common gynaecological malignancy in the developing world, particularly in sub-Saharan Africa.Aim: To determine the prevalence of abnormal cervical cytology amongst women with and without human immunodeficiency virus (HIV) and examine the association between HIV and histological grading.Setting: The study was conducted in Limpopo province, which is the northernmost province of South Africa. The province has five district municipalities with one tertiary, five regional and thirty four district hospitals.Methods: We retrospectively reviewed cervical cancer cases in Limpopo province (LP) of South Africa, using data collected routinely by the National Health Laboratory Services (NHLS). The data on smears submitted for cytology between 2013 and 2015 were extracted from the Central Data Warehouse (CDW) database.Results: A total of 84 466 women were screened for cervical cytology smears. Their mean age was 39.8 ± 13.6 years, with range from 15 to 113 years; 77.2% were in the age group 30 years and older and 19.6% had an abnormal cervical cytology result. Overall, 46.4% of the women screened for cervical cancer were HIV infected. A significantly higher proportion of HIV-positive women had abnormal cytology than HIV-negative women (31.8% vs. 9.2%).Conclusion: The prevalence of abnormal cytology amongst HIV-positive women is relatively high, and the risk appears to be significantly greater in all age groups. This finding highlights the need to ascertain HIV status of all women presenting with cervical cancer.

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