Role of the greater sciatic notch of the hip bone in sexual dimorphism: a morphometric study of the North Indian population

Background: The role of single nucleotide polymorphism rs10937405 (C>T) of the TP63 gene in cancer including leu- kemia has previously been studied in different world populations; however, the role of this variant in leukemia in the North Indian population of Jammu and Kashmir is still unknown. Objectives: In the present study, we investigated the association of genetic variant rs10937405 with leukemic in the Jammu and Kashmir population. Methods: A total of 588 subjects, (188 cases and 400 controls) were recruited for the study. The rs10937405 variant was genotyped by using the real-time based TaqMan assay. Results: A statistically significant association was observed between the rs10937405 and leukemia [OR of 1.94 (95% CI 1.51-2.48), p=1.2x10-6]. Conclusion: The current study concludes that the rs10937405 variant is a risk factor for the development of leukemia in the population of Jammu and Kashmir, North India. However, it would be interesting to explore the contribution of this variant in other cancers as well. Our findings will help in the development of diagnostic markers for leukemia in the studied population and potentially for other North Indian populations. Keywords: Single Nucleotide Polymorphism (SNPs); Leukemia; North Indian population; Tumour suppressor (TP63); Linkage Disequilibrium (LD); Genome wide association studies (GWAS); Jammu and Kashmir (J &K).

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Differential role of sodium channelsSCN1AandSCN2Agene polymorphisms with epilepsy and multiple drug resistance in the north Indian population

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.2009.03437.x ◽

2009 ◽

Vol 68 (2) ◽

pp. 214-220 ◽

Cited By ~ 47

Author(s):

Ram Lakhan ◽

Ritu Kumari ◽

Usha K. Misra ◽

Jayanti Kalita ◽

Sunil Pradhan ◽

...

Keyword(s):

Drug Resistance ◽

Indian Population ◽

Multiple Drug Resistance ◽

Multiple Drug ◽

North Indian Population ◽

The North

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Association of Genetic Variants of ELMO1 Gene With Diabetic Nephropathy in the North Indian Population

10.21203/rs.3.rs-121795/v1 ◽

2020 ◽

Author(s):

Gurvinder Singh ◽

Rubina Sharma ◽

Priyanka Raina ◽

Vishali Kalotra ◽

Harkirat Sandhu ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Physical Inactivity ◽

Indian Population ◽

Linkage Disequilibrium Mapping ◽

North Indian Population ◽

The North ◽

High Doses ◽

Stage Renal Disease ◽

End Stage

Abstract Diabetic nephropathy (DN) is a major cause of renal failure globally including chronic kidney disease and end-stage renal disease (ESRD). Using comprehensive linkage disequilibrium mapping, we genotyped five polymorphisms from engulfment and cell motility 1 (ELMO1) gene (rs741301, rs7799004, rs1882080, rs11769038 and rs1345365) to evaluate its association with DN. BMI was observed to be low in DN cases as compared to the control groups, which is the result of haemodialysis and high doses of medication. Physical inactivity, lipid profile, urea and creatinine were observed to be the confounding factors correlated with DN. This study comprehensively evaluated ELMO1 in DN patients, T2D without Nephropathy and healthy controls from North Indian population and revealed significant association with DN. Haplotypes G-G-C-C and G-A-T-T provided ~2-fold risk towards DN development. In conclusion, the present study suggests the significant role of ELMO1 gene polymorphisms in the pathophysiology of DN in North-Indian population.

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