Functional Magnetic Resonance Imaging of Language Following Constraint-Induced Aphasia Therapy Primed with Intermittent Theta Burst Stimulation in 13 Patients with Post-Stroke Aphasia

Theta burst stimulation (TBS) is associated with a range of clinical, cognitive, and behavioural outcomes, but specific neurobiological effects remain somewhat unclear. This systematic literature review investigated resting-state and task-based functional magnetic resonance imaging (fMRI) outcomes post TBS in healthy human adults. Forty-two studies that applied either continuous- or intermittent- (c/i) TBS, and adopted a pretest-posttest and/or sham-controlled design, were included. For resting-state outcomes following stimulation applied to motor, temporal, parietal, occipital, or cerebellar regions, functional connectivity generally decreased in response to cTBS and increased in response to iTBS, though there were some exceptions to this pattern of response. This is mostly consistent with the assumed long-term depression (LTD)/long-term potentiation (LTP)-like plasticity effects of cTBS and iTBS, respectively. Task-related outcomes following TBS were more variable. TBS applied to the frontal cortex, irrespective of task or state, also produced more variable responses, with no consistent patterns emerging. Individual participant and methodological factors are likely to contribute to the variability in responses to TBS. Future studies assessing the effects of TBS via fMRI must account for factors known to affect the response to TBS, both at the level of individual participants and of research methodology.

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Theta-Burst Stimulation for Auditory-Verbal Hallucination in Very-Late-Onset Schizophrenia-Like Psychosis—A Functional Magnetic Resonance Imaging Case Study

Frontiers in Psychiatry ◽

10.3389/fpsyt.2020.00294 ◽

2020 ◽

Vol 11 ◽

Cited By ~ 1

Author(s):

Rebecca Zöllner ◽

Anne-Friederike Hübener ◽

Udo Dannlowski ◽

Tilo Kircher ◽

Jens Sommer ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Late Onset ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Theta Burst Stimulation ◽

Burst Stimulation ◽

Auditory Verbal Hallucination ◽

Theta Burst

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Functional Magnetic Resonance Imaging Before and After Aphasia Therapy

Stroke ◽

10.1161/01.str.0000110983.50753.9d ◽

2004 ◽

Vol 35 (2) ◽

pp. 554-559 ◽

Cited By ~ 78

Author(s):

Kyung K. Peck ◽

Anna B. Moore ◽

Bruce A. Crosson ◽

Megan Gaiefsky ◽

Kaundinya S. Gopinath ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Aphasia Therapy ◽

Before And After

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Efficacy and Mechanism of Abdominal Acupuncture as a Poststroke Intervention for Promoting Upper-limb Motor Recovery: A Study Protocol of A Randomized Controlled Trial

10.21203/rs.2.9927/v1 ◽

2019 ◽

Author(s):

Ruihuan Pan ◽

Shanshan Ling ◽

Jingping XIE ◽

Youhua Guo ◽

Yiping Zhong ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Motor Imagery ◽

Upper Limb ◽

Surface Electromyography ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Post Stroke ◽

Abdominal Acupuncture

Abstract Background: How to promote true recovery from poststroke upper limb motor impairment has remained an urgent public health problem. Acupuncture has the potential to facilitate poststroke recovery. Abdominal acupuncture, based on the recently discovered acupoint system on the anterior abdominal wall, appears attractive because it induces less pain, and allows concurrent limb rehabilitative training during treatment. However, its clinical efficacy has not been systematically demonstrated, and its neurophysiological mechanism has remained obscure. Methods: First-onset stroke survivors (0.5-3 months post-stroke) will be randomly divided into 3 groups (N=22 in each), respectively receiving (1) abdominal acupuncture, (2) abdominal acupuncture with sham needles, and (3) no acupuncture. All subjects will concurrently receive basic treatment, including upper limb rehabilitative training and measures for secondary stroke prevention. Clinical scores reflective of motor functions and impairment (Wolf motor function test, Fugl-Meyer assessment, Brunnstrom staging), evaluation of daily life ability, surface electromyography, and motor-imagery functional magnetic resonance imaging will be collected as outcome measures before and after intervention. Upper-limb muscle synergies will be identified from the collected surface electromyography. Discussion: The study will use abdominal acupuncture to improve recovery from motor dysfunction of the upper limb after stroke, to observe the effects of abdominal acupuncture on post-stroke upper limb motor functions, and to analyze the relationship between changes in upper-limb functions and measurements from both multi-muscle surface electromyographic data and brain activations during motor imagery from functional magnetic resonance imaging, so as to explore possible mechanisms of neuroplasticity associated with abdominal acupuncture. Trial registration: This trial was registered with the ClinicalTrials.gov (ID: NCT03712085) on 7th July 2018, and last updated on 16th Oct 2018.

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