scholarly journals Neuroimaging in the Differential Diagnosis of Primary Progressive Aphasia – Illustrative Case Series in the Light of New Diagnostic Criteria

2014 ◽  
Vol 79 ◽  
pp. 251-258 ◽  
Author(s):  
Jarosław Sławek
Keyword(s):  
Differential Diagnosis ◽  
Diagnostic Criteria ◽  
Case Series ◽  
Primary Progressive Aphasia ◽  
Illustrative Case ◽  
Progressive Aphasia ◽  
Primary Progressive

Early and Mild Phases of Primary Progressive Aphasia: A Case Series

2017 ◽  
Vol 10 (2) ◽  
pp. 136-142
Author(s):  
Jessica Powell ◽  
James Lendrum ◽  
Rosalind Huff ◽  
Christine Belden ◽  
Marwan N. Sabbagh
Keyword(s):  
Case Series ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Contribution of the Cognitive Approach to Language Assessment to the Differential Diagnosis of Primary Progressive Aphasia

2021 ◽  
Vol 11 (6) ◽  
pp. 815
Author(s):  
Joël Macoir ◽  
Annie Légaré ◽  
Monica Lavoie
Keyword(s):  
Differential Diagnosis ◽  
Language Impairment ◽  
Primary Progressive Aphasia ◽  
Behavioral Management ◽  
Language Abilities ◽  
Cognitive Approach ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Assessment Approach ◽  
Cognitive Neuropsychological

Diagnosis of primary progressive aphasia (PPA) is essentially based on the identification of progressive impairment of language abilities while other cognitive functions are preserved. The three variants of PPA are characterized by core and supportive clinical features related to the presence or absence of language impairment in different linguistic domains. In this article, we review the cognitive neuropsychological approach to the assessment of PPA and its contribution to the differential diagnosis of the three variants. The main advantage of this assessment approach is that it goes beyond the mere description and classification of clinical syndromes and identifies impaired and preserved cognitive and linguistic components and processes. The article is structured according to the main language domains: spoken production, language comprehension, and written language. Each section includes a brief description of the cognitive processes involved in the assessment tasks, followed by a discussion of typical characteristics for each PPA variant and common pitfalls in the interpretation of the results. In addition, the clinical benefit of the cognitive neuropsychological approach for the behavioral management of PPA is briefly sketched out in the conclusion.

Lexical retrieval treatment in primary progressive aphasia: An investigation of treatment duration in a heterogeneous case series

Cortex ◽  
2019 ◽  
Vol 115 ◽  
pp. 133-158 ◽  
Author(s):  
Karen Croot ◽  
Theresa Raiser ◽  
Cathleen Taylor-Rubin ◽  
Leanne Ruggero ◽  
Nibal Ackl ◽  
...  
Keyword(s):  
Treatment Duration ◽  
Case Series ◽  
Primary Progressive Aphasia ◽  
Lexical Retrieval ◽  
Progressive Aphasia ◽  
Primary Progressive

P3-220: The Mild Cognitive Impairment of Primary Progressive Aphasia: A Case Series

2016 ◽  
Vol 12 ◽  
pp. P909-P910
Author(s):  
Jessica Powell ◽  
James Lendrum ◽  
Rosalind Huff ◽  
Christine Belden ◽  
Marwan N. Sabbagh
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Case Series ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Primary progressive aphasia: Classification of variants in 100 consecutive Brazilian cases

2013 ◽  
Vol 7 (1) ◽  
pp. 110-121 ◽  
Author(s):  
Mirna Lie Hosogi Senaha ◽  
Paulo Caramelli ◽  
Sonia M.D. Brucki ◽  
Jerusa Smid ◽  
Leonel T. Takada ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Language Impairment ◽  
Demographic Data ◽  
Primary Progressive Aphasia ◽  
Clinical Syndrome ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Diagnosis And Classification ◽  
Consensus Classification

ABSTRACT Primary progressive aphasia (PPA) is a neurodegenerative clinical syndrome characterized primarily by progressive language impairment. Recently, consensus diagnostic criteria were published for the diagnosis and classification of variants of PPA. The currently recognized variants are nonfluent/agrammatic (PPA-G), logopenic (PPA-L) and semantic (PPA-S). Objective: To analyze the demographic data and the clinical classification of 100 PPA cases. Methods: Data from 100 PPA patients who were consecutively evaluated between 1999 and 2012 were analyzed. The patients underwent neurological, cognitive and language evaluation. The cases were classified according to the proposed variants, using predominantly the guidelines proposed in the consensus diagnostic criteria from 2011. Results: The sample consisted of 57 women and 43 men, aged at onset 67.2±8.1 years (range of between 53 and 83 years). Thirty-five patients presented PPA-S, 29 PPA-G and 16 PPA-L. It was not possible to classify 20% of the cases into any one of the proposed variants. Conclusion: It was possible to classify 80% of the sample into one of the three PPA variants proposed. Perhaps the consensus classification requires some adjustments to accommodate cases that do not fit into any of the variants and to avoid overlap where cases fit more than one variant. Nonetheless, the established current guidelines are a useful tool to address the classification and diagnosis of PPA and are also of great value in standardizing terminologies to improve consistency across studies from different research centers.

scholarly journals Spontaneous oscillatory activity in response to intensive tDCS and anomia therapy in primary progressive aphasia: A case series

2018 ◽  
Vol 12 ◽  
Author(s):  
Jed Meltzer ◽  
Tiffany Deschamps ◽  
Alexander Francois-Nienaber ◽  
Selina Teti ◽  
Regina Jokel ◽  
...  
Keyword(s):  
Case Series ◽  
Primary Progressive Aphasia ◽  
Oscillatory Activity ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example

2020 ◽  
Vol 29 (4) ◽  
pp. 1833-1849
Author(s):  
Eduardo Europa ◽  
Leonardo Iaccarino ◽  
David C. Perry ◽  
Elizabeth Weis ◽  
Ariane E. Welch ◽  
...  
Keyword(s):  
Positron Emission Tomography Imaging ◽  
Evaluation Process ◽  
Primary Progressive Aphasia ◽  
Diagnostic Assessment ◽  
Pharmacological Intervention ◽  
Illustrative Case ◽  
Speech Language Pathologists ◽  
Learning Abilities ◽  
Progressive Aphasia ◽  
Primary Progressive

Purpose Diagnosis and classification of primary progressive aphasia (PPA) requires confirmation of specific speech and language symptoms, highlighting the important role of speech-language pathologists in the evaluation process. The purpose of this case report is to inform speech-language pathologists regarding current practices for diagnostic assessment in PPA, describing standard approaches as well as complementary, state-of-the-art procedures that may improve diagnostic precision. Method We describe the diagnostic evaluation of a 49-year-old woman with complaints of progressive word-finding difficulty. She completed standard neurological, neuropsychological, and speech-language evaluations, as well as magnetic resonance and positron emission tomography imaging of her brain. In addition, a history of developmental speech, language, and learning abilities was obtained, as well as genetic testing and assessment of cerebrospinal fluid biomarkers. We discuss the evaluation results in the context of the most current research related to PPA diagnosis. Conclusion Detailed behavioral assessment, thorough intake of symptom history and neurodevelopmental differences, multimodal neuroimaging, and comprehensive examination of genes and biomarkers are of paramount importance for detecting and characterizing PPA, with ramifications for early behavioral and/or pharmacological intervention. Supplemental Material https://doi.org/10.23641/asha.12771113

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