scholarly journals Differential diagnosis dilemma: A case of possible primary progressive aphasia versus aphasic dementia

1999 ◽  
Vol 14 (1) ◽  
pp. 121-121
Author(s):  
M. T. Barisa ◽  
J. Schumacher
Keyword(s):  
Differential Diagnosis ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Contribution of the Cognitive Approach to Language Assessment to the Differential Diagnosis of Primary Progressive Aphasia

2021 ◽  
Vol 11 (6) ◽  
pp. 815
Author(s):  
Joël Macoir ◽  
Annie Légaré ◽  
Monica Lavoie
Keyword(s):  
Differential Diagnosis ◽  
Language Impairment ◽  
Primary Progressive Aphasia ◽  
Behavioral Management ◽  
Language Abilities ◽  
Cognitive Approach ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Assessment Approach ◽  
Cognitive Neuropsychological

Diagnosis of primary progressive aphasia (PPA) is essentially based on the identification of progressive impairment of language abilities while other cognitive functions are preserved. The three variants of PPA are characterized by core and supportive clinical features related to the presence or absence of language impairment in different linguistic domains. In this article, we review the cognitive neuropsychological approach to the assessment of PPA and its contribution to the differential diagnosis of the three variants. The main advantage of this assessment approach is that it goes beyond the mere description and classification of clinical syndromes and identifies impaired and preserved cognitive and linguistic components and processes. The article is structured according to the main language domains: spoken production, language comprehension, and written language. Each section includes a brief description of the cognitive processes involved in the assessment tasks, followed by a discussion of typical characteristics for each PPA variant and common pitfalls in the interpretation of the results. In addition, the clinical benefit of the cognitive neuropsychological approach for the behavioral management of PPA is briefly sketched out in the conclusion.

scholarly journals Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis

2021 ◽  
Vol 11 (9) ◽  
pp. 1198
Author(s):  
Alexandra Plonka ◽  
Aurélie Mouton ◽  
Joël Macoir ◽  
Thi-Mai Tran ◽  
Alexandre Derremaux ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Healthy Subjects ◽  
Language Disorder ◽  
Primary Progressive Aphasia ◽  
Clinical Settings ◽  
Healthy Controls ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Digital Tablet

Primary progressive aphasia (PPA) brings together neurodegenerative pathologies whose main characteristic is to start with a progressive language disorder. PPA diagnosis is often delayed in non-specialised clinical settings. With the technologies’ development, new writing parameters can be extracted, such as the writing pressure on a touch pad. Despite some studies having highlighted differences between patients with typical Alzheimer’s disease (AD) and healthy controls, writing parameters in PPAs are understudied. The objective was to verify if the writing pressure in different linguistic and non-linguistic tasks can differentiate patients with PPA from patients with AD and healthy subjects. Patients with PPA (n = 32), patients with AD (n = 22) and healthy controls (n = 26) were included in this study. They performed a set of handwriting tasks on an iPad® digital tablet, including linguistic, cognitive non-linguistic, and non-cognitive non-linguistic tasks. Average and maximum writing pressures were extracted for each task. We found significant differences in writing pressure, between healthy controls and patients with PPA, and between patients with PPA and AD. However, the classification of performances was dependent on the nature of the tasks. These results suggest that measuring writing pressure in graphical tasks may improve the early diagnosis of PPA, and the differential diagnosis between PPA and AD.

scholarly journals First Symptoms of Primary Progressive Aphasia and Alzheimer's Disease in Brazilian Individuals

2021 ◽  
Vol 12 ◽  
Author(s):  
Talita Gallas dos Reis ◽  
Thais Helena Machado ◽  
Paulo Caramelli ◽  
Francisco Scornavacca ◽  
Liana Lisboa Fernandez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
Latin American ◽  
Primary Progressive Aphasia ◽  
Motor Speech ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Initial Symptoms ◽  
Semantic Variant

Background: Primary Progressive Aphasia (PPA) is characterized by progressive language impairment due to focal degeneration of brain areas related to linguistic processing. The detection and differential diagnosis of PPA can be difficult with clinical features that may overlap with features of other neurological conditions, such as Alzheimer's disease (AD). The scientific production on PPA in Latin American patients is still scarce. This study investigated the first symptoms in a Brazilian sample of patients with PPA in comparison with AD patients.Method: We compared the first symptoms reported by caregivers of people with PPA (n = 20; semantic variant n = 8, non-fluent variant n = 7, logopenic variant n = 3, and unclassified cases n = 2) and AD (n = 16). Data were collected through the application of a structured questionnaire that was presented in an interview format to the caregiver who knew the patient best.Results: Anomia, paraphasias and motor speech difficulties were the first symptoms capable of differentiating patients with PPA from those with AD, while memory was exclusive of AD. Among the PPA variants, anomia was the initial symptom associated with the semantic variant, while motor speech difficulties were associated with the non-fluent variant. The results are discussed considering the unique cultural and sociodemographic characteristics of this studied population.Conclusion: This study demonstrated that some of the initial symptoms of PPA patients may be unique to clinical variants of PPA and of AD, and their investigation may be useful for the early and differential diagnosis of this population.

scholarly journals Heterogeneity of repetition abilities in logopenic variant primary progressive aphasia

2021 ◽  
Vol 15 (3) ◽  
pp. 405-412
Author(s):  
Joel Macoir ◽  
Vicent Martel-Sauvageau ◽  
Liziane Bouvier ◽  
Robert Laforce ◽  
Laura Monetta
Keyword(s):  
Working Memory ◽  
Differential Diagnosis ◽  
Clinical Manifestations ◽  
Primary Progressive Aphasia ◽  
Syntactic Complexity ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Sentence Repetition ◽  
Psycholinguistic Variables ◽  
Language Assessments

ABSTRACT. The differential diagnosis of primary progressive aphasia (PPA) is challenging due to overlapping clinical manifestations of the different variants of the disease. This is particularly true for the logopenic variant of PPA (lvPPA), in which such overlap was reported with regard to impairments in repetition abilities. In this study, four individuals with lvPPA underwent standard neuropsychological and language assessments. The influence of psycholinguistic variables on their performance of in word, nonword and sentence repetition tasks was also specifically explored. Some level of heterogeneity was found in cognitive functions and in language. The four participants showed impairment in sentence repetition in which their performance was negatively affected by semantic reversibility and syntactic complexity. This study supports the heterogeneity of lvPPA with respect to the cognitive and linguistic status of participants. It also shows that sentence repetition is influenced not only by length, but also by semantic reversibility and syntactic complexity, two psycholinguistic variables known to place additional demands on phonological working memory.

The Combination of Metabolic Posterior Cingulate Cortical Abnormalities and Structural Asymmetries Improves the Differential Diagnosis Between Primary Progressive Aphasia and Alzheimer’s Disease

2021 ◽  
pp. 1-7
Author(s):  
Micaela Mitolo ◽  
Michelangelo Stanzani-Maserati ◽  
David N. Manners ◽  
Sabina Capellari ◽  
Claudia Testa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
Primary Progressive Aphasia ◽  
Posterior Cingulate Cortex ◽  
Structural Imaging ◽  
Proton Mr Spectroscopy ◽  
Progressive Aphasia ◽  
Posterior Cingulate ◽  
Primary Progressive

Differential diagnosis between primary progressive aphasia (PPA) and Alzheimer’s disease (AD) could be difficult if based on clinical grounds alone. We evaluated the combination of proton MR spectroscopy of posterior cingulate cortex (PCC) and quantitative structural imaging asymmetries to differentiate PPA from AD patients. A greater left-lateralized temporo-parietal atrophy (higher accuracy for the PCC, 81.4%) and metabolic neurodegenerative changes in PCC (accuracy 76.8%) was demonstrated in PPA versus AD. The combined multiparametric approach increased the accuracy to 94%in the differential diagnosis between these two neurodegenerative diseases.

scholarly journals A case of primary progressive aphasia syndrome Clinical features, brain imagings and differential diagnosis.

1992 ◽  
Vol 12 (4) ◽  
pp. 337-344
Author(s):  
Saiko Murai ◽  
Toshiko Mori ◽  
Kenji Hara ◽  
Takeshi Yasuda ◽  
Akira Terao
Keyword(s):  
Differential Diagnosis ◽  
Clinical Features ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive
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