scholarly journals Diagnostic accuracy of NMP 22 and urine cytology for detection of transitional cell carcinoma urinary bladder taking cystoscopy as gold standard

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Muhammad Tanveer Sajid ◽  
Muhammad Rafiq Zafar ◽  
Hussain Ahmad ◽  
Saif Ullah ◽  
Zahoor Iqbal Mirza ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Diagnostic Accuracy ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Roc Curve ◽  
Predictive Value ◽  
Gold Standard ◽  
Transitional Cell ◽  
Urine Cytology ◽  
Female Ratio

Objective: To determine diagnostic accuracy of NMP 22 and urine cytology in the detection of transitional cell carcinoma (TCC) urinary bladder taking cystoscopy as a gold standard in patients having provisional diagnosis of bladder cancer (BC). Methods: This cross sectional validational study enrolled 380 patients fulfilling selection criteria and was conducted at Armed Forces Institute of Urology (AFIU) Rawalpindi, Pakistan form July 2018 to July 2019. The urine sample collected underwent NMP22 and cytological analysis followed by rigid cystoscopy. Reports of all three tests divided patients into positive or negative for malignancy as per defined criteria. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of NMP 22, urine cytology and their combination was determined. Receiver operating characteristic (ROC) curve analysis performed and area under the curve (AUC) compared among these tests. Results: The average age of patients was 53.08 ± 12.41 years having male to female ratio 3.75:1(300 males and 80 females). NMP 22 had better sensitivity and comparable specificity to cytology (81.9 & 81.2% vs 54 & 93.9%). Combination of NMP 22 / cytology outperformed both in terms of sensitivity (91.63 vs 81.83 vs 53.96), NPV (87.59 vs 77.46 vs 61.02) and diagnostic accuracy (85.26 vs 81.58 vs 71.32) but at the cost of specificity (76.97 vs 81.21 vs 93.94) and PPV (83.83 vs 85.02 vs 92.06). ROC curve revealed statistically significant higher AUC (0.843 vs .815 vs .73) for combination as compared to NMP 22 and Cytology (p<0.001). Conclusion: NMP22 is a quick, point of care test having higher sensitivity, NPV and accuracy but similar specificity and PPV to urine cytology for detection of TCC urinary bladder. Combination outperformed both in terms of sensitivity while having modest specificity. doi: https://doi.org/10.12669/pjms.36.4.1638 How to cite this:Sajid MT, Zafar MR, Ahmad H, Saif Ullah, Mirza ZI, Shahzad K. Diagnostic accuracy of NMP 22 and urine cytology for detection of transitional cell carcinoma urinary bladder taking cystoscopy as gold standard. Pak J Med Sci. 2020;36(4):---------.  doi: https://doi.org/10.12669/pjms.36.4.1638 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Combined urine Cytology and Cystoscopy can detect recurrence of superficial transitional cell carcinoma of the urinary bladder.

2019 ◽  
Vol 12 (1) ◽  
pp. 1-5
Author(s):  
Mohammad Shafiqur Rahman ◽  
ASM Azizur Rahman Siddique ◽  
Mohammad Saiful Islam ◽  
Faika Farah Ahmed
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
False Positive ◽  
Transitional Cell ◽  
False Negative ◽  
Urine Cytology ◽  
Targeted Biopsy ◽  
Bladder Biopsy ◽  
Visible Growth

The study was aimed to evaluate the accuracy of combined urine cytology and cystoscopy for the detection of recurrence of superficial transitional cell carcinoma of the urinary bladder without bladder biopsy. Total 60 patients of superficial TCC of urinary bladder were selected of these 48 were male and 12 were female with age were between 41 to 80 years (mean age- 63.15 years).Urine cytology was done for all patients .Then cystoscopy done with targeted biopsy taken from any apparently visible growth in the bladder and systematic biopsy were taken where there was no growth. Reports of the cytology and cystoscopy were compared with the histopathology reports.It was found that 18 patients were cytology positive (false positive 2) and 42 patients were cytology negative (false negative 10) with sensitivity 61.5% and specificity 94%. During cystoscopy 24 patients were found recurrent growth in the bladder (false positive 3) and 36 patients were negative (false negative 5) with sensitivity 80.7% and specificity 91%. But when combined urine cytology and cystoscopic findings evaluated, the sensitivity and specificity were found 100% and 91% respectively.So, combined urine cytology and cystoscopy can be used for the detection of recurrence of superficial TCC. Key Ward- Urine Cytology, Cystoscopy, Bladder Biopsy

scholarly journals Role of Ultrasound in the Evaluation of Urinary Bladder Neoplasm with Histopathological Correlation

1970 ◽  
Vol 21 (2) ◽  
pp. 155-159 ◽  
Author(s):  
AHM Tohurul Islam ◽  
Syeda Nazlee Mostafa ◽  
Mizanur Rahman ◽  
Ziban Nahar
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Predictive Value ◽  
Bladder Tumor ◽  
Transitional Cell ◽  
Posterior Wall ◽  
Bladder Neoplasm ◽  
Urinary Bladder Neoplasm ◽  
Diagnostic Modality ◽  
Female Ratio

A descriptive study was carried out on 41 consecutive patients of clinically suspected bladder tumor presented with haematuria, which were studied by ultrasonography and was confirmed histopathologically. Per abdominal sonographic scan of KUB region, especially lower abdomen was done in full bladder state in supine position. Bladder lumens as well as peri-vesical structures were also studied. The sensitivity and specificity of ultrasonography were 96.87% and 60% respectively. The accuracy of ultrasonography was 91.89%. Positive predictive value 93.39% and negative predictive value was 75%. Histopathological types of bladder tumor where 90.63% were transitional cell carcinoma, 6.25% were adenocarcinoma and 3.13% were squamous cell carcinoma. The highest incidence was noted in the posterior wall of the bladder (53.13%) followed by lateral walls (35.50%), roof (03.13%) & the bladder neck (06.25%). The peak age incidence was in 5th to 7th decade, having mean age 57.4 ±2.3 years. Male to female ratio was 9.67:1 and most of them having the habit of smoking (81.25%). Highest incidence of bladder tumor was found in subjects belonging to blood group ‘O' (53.13%), followed by ‘A' (25%), ‘B' (18.75%) ‘AB' (3.13%). All the cases belong to Rhesus positive group. Bladder tumor was higher among the low socio-economic group (43.75%), followed by below average (34.38%), average (15.63%) and good (6.25%). Ultrasound is a very useful modality in diagnosis of urinary bladder neoplasm, which is cheap, easily available, noninvasive and negligible discomfort. So, sonographic scan can be recommended as a useful diagnostic modality in respect of urinary bladder neoplasm. doi: 10.3329/taj.v21i2.3797 TAJ 2008; 21(2): 155-159

scholarly journals Mitomycin c in the treatment of metastatic transitional cell carcinoma of urinary bladder

Cancer ◽  
1973 ◽  
Vol 31 (5) ◽  
pp. 1150-1153 ◽  
Author(s):  
K. Early ◽  
E. G. Elias ◽  
A. Mittelman ◽  
D. Albert ◽  
G. P. Murphy
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mitomycin C ◽  
Transitional Cell

Transitional cell carcinoma of the urinary bladder in a spectacled bear (Tremarctos ornatus)

2006 ◽  
Vol 158 (9) ◽  
pp. 306-307 ◽  
Author(s):  
S. Murray ◽  
C. D. Sanchez ◽  
G. H. Siemering ◽  
K. Enqvist ◽  
S. L. Deem
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell

Micropapillary Variant of Transitional Cell Carcinoma of the Urinary Bladder

2001 ◽  
Vol 45 (4) ◽  
pp. 599-604 ◽  
Author(s):  
Lourdes R. Ylagan ◽  
Peter A. Humphrey
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell
Sign in / Sign up

Export Citation Format

Share Document