scholarly journals Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 303
Author(s):  
Maysaa El Sayed Zaki ◽  
Dina Elhammady ◽  
Mona Foda Salama ◽  
Mostafa Abdelsalam ◽  
Asmaa Osama Bakr Osman
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gastrointestinal Disorder ◽  
The Other ◽  
University Hospital ◽  
Cytolethal Distending Toxin ◽  
Retrospective Case ◽  
Toxin B ◽  
Control Subjects ◽  
Irritable Bowel ◽  
Post Infectious

Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, categorized into various subtypes. Post-infection IBS may be attributed to the release of cytolethal distending toxin B (CdtB), which cross-reacts with the adhesion protein vinculin responsible for normal intestinal contractility. Objective: This study aims to identify anti-CdtB and anti-vinculin levels in IBS patients compared to healthy control. Subjects and methods: This retrospective case-control study was conducted on 100 subjects with IBS, as determined by a questionnaire based on Rome III criteria, recruited from the outpatient clinics of the Tropical Medicine at Mansoura University Hospital from January 2019 to January 2020. Results: Anti-vinculin and anti-CdtB levels were significantly elevated in patients with IBS (1.58±0.496, 2.47±0.60)  when compared to control subjects (1.13±0.249ng/ml, 2.1±0.24 ng/ml), respectively with P=0.001 for both.  Anti-vinculin level was significantly higher in the IBS-D subtype than the other subtypes (P=0.001) while, Anti-CdtB was significantly elevated in IBS-C, IBS-D subgroups compared to control subjects (P=0.001). Conclusion: Findings of the present study support the hypothesis that IBS results from post-infectious disorders initiated by bacterial enteritis. A hypothesis could be applied to all IBS subgroups. On the other hand. These biomarkers might reflect the post-infectious state's severity.

scholarly journals Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 303
Author(s):  
Maysaa El Sayed Zaki ◽  
Dina Elhammady ◽  
Mona Foda Salama ◽  
Mostafa Abdelsalam ◽  
Asmaa Osama Bakr Osman
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gastrointestinal Disorder ◽  
The Other ◽  
University Hospital ◽  
Cytolethal Distending Toxin ◽  
Retrospective Case ◽  
Toxin B ◽  
Control Subjects ◽  
Irritable Bowel ◽  
Post Infectious

Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, categorized into various subtypes. Post-infection IBS may be attributed to the release of cytolethal distending toxin B (CdtB), which cross-reacts with the adhesion protein vinculin responsible for normal intestinal contractility. Objective: This study aims to identify anti-CdtB and anti-vinculin levels in IBS patients compared to healthy control. Subjects and methods: This retrospective case-control study was conducted on 100 patients with IBS, as determined by a questionnaire based on Rome IV criteria, recruited from the outpatient clinics of the Tropical Medicine at Mansoura University Hospital from January 2019 to January 2020. Results: Anti-vinculin and anti-CdtB levels were significantly elevated in patients with IBS (1.58±0.496ng/ml, 2.47±0.60ng/ml)  when compared to control subjects (1.13±0.249ng/ml, 2.1±0.24 ng/ml), respectively with P=0.001 for both.  Anti-vinculin level was significantly higher in the IBS-D subtype than the other subtypes (P=0.001) while, Anti-CdtB was significantly elevated in IBS-C, IBS-D subgroups compared to control subjects (P=0.001). Conclusion: Findings of the present study support the hypothesis that IBS results from post-infectious disorders initiated by bacterial enteritis. A hypothesis could be applied to all IBS subgroups. On the other hand. These biomarkers might reflect the post-infectious state's severity. These findings need further extensive longitudinal studies in patients with IBS.

scholarly journals Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 303
Author(s):  
Maysaa El Sayed Zaki ◽  
Dina Elhammady ◽  
Mona Foda Salama ◽  
Mostafa Abdelsalam ◽  
Asmaa Osama Bakr Osman
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gastrointestinal Disorder ◽  
The Other ◽  
University Hospital ◽  
Cytolethal Distending Toxin ◽  
Retrospective Case ◽  
Toxin B ◽  
Control Subjects ◽  
Irritable Bowel ◽  
Post Infectious

Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, categorized into various subtypes. Post-infection IBS may be attributed to the release of cytolethal distending toxin B (CdtB), which cross-reacts with the adhesion protein vinculin responsible for normal intestinal contractility. Objective: This study aims to identify anti-CdtB and anti-vinculin levels in IBS patients compared to healthy control. Subjects and methods: This retrospective case-control study was conducted on 100 subjects with IBS, as determined by a questionnaire based on Rome IV criteria, recruited from the outpatient clinics of the Tropical Medicine at Mansoura University Hospital from January 2019 to January 2020. Results: Anti-vinculin and anti-CdtB levels were significantly elevated in patients with IBS (1.58±0.496ng/ml, 2.47±0.60ng/ml)  when compared to control subjects (1.13±0.249ng/ml, 2.1±0.24 ng/ml), respectively with P=0.001 for both.  Anti-vinculin level was significantly higher in the IBS-D subtype than the other subtypes (P=0.001) while, Anti-CdtB was significantly elevated in IBS-C, IBS-D subgroups compared to control subjects (P=0.001). Conclusion: Findings of the present study support the hypothesis that IBS results from post-infectious disorders initiated by bacterial enteritis. A hypothesis could be applied to all IBS subgroups. On the other hand. These biomarkers might reflect the post-infectious state's severity. These findings need further extensive longitudinal studies in patients with IBS.

scholarly journals Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 303
Author(s):  
Maysaa El Sayed Zaki ◽  
Dina Elhammady ◽  
Mona Foda Salama ◽  
Mostafa Abdelsalam ◽  
Asmaa Osama Bakr Osman
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gastrointestinal Disorder ◽  
The Other ◽  
University Hospital ◽  
Cytolethal Distending Toxin ◽  
Retrospective Case ◽  
Toxin B ◽  
Control Subjects ◽  
Irritable Bowel ◽  
Post Infectious

Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, categorized into various subtypes. Post-infection IBS may be attributed to the release of cytolethal distending toxin B (CdtB), which cross-reacts with the adhesion protein vinculin responsible for normal intestinal contractility. Objective: This study aims to identify anti-CdtB and anti-vinculin levels in IBS patients compared to healthy control. Subjects and methods: This retrospective case-control study was conducted on 100 subjects with IBS, as determined by a questionnaire based on Rome III criteria, recruited from the outpatient clinics of the Tropical Medicine at Mansoura University Hospital from January 2019 to January 2020. Results: The optical density (OD) results of the anti-vinculin and anti-CdtB levels were significantly elevated in patients with IBS (1.58±0.496 OD, 2.47±0.60 OD)  when compared to control subjects (1.13±0.249 OD, 2.1±0.24 OD), respectively with P=0.001 for both.  Anti-vinculin level was significantly higher in the IBS-D subtype than the other subtypes (P=0.001) while, Anti-CdtB was significantly elevated in IBS-C, IBS-D subgroups compared to control subjects (P=0.001). Conclusion: Findings of the present study support the hypothesis that IBS results from post-infectious disorders initiated by bacterial enteritis. A hypothesis could be applied to all IBS subgroups. On the other hand. These biomarkers might reflect the post-infectious state's severity.

scholarly journals Diarrhea syndrome: new accents of patient curation during COVID-19 pandemic

2021 ◽  
Vol 5 (6) ◽  
pp. 446-452
Author(s):  
O.V. Gaus ◽  
◽  
M.A. Livzan ◽  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Ischemic Colitis ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Gastrointestinal Disorder ◽  
Infected People ◽  
Antibiotic Associated Diarrhea ◽  
Irritable Bowel ◽  
Diarrhea Syndrome ◽  
Post Infectious

The digestive tract, like the respiratory organs, is the entrance gate for SARS-CoV-2. At the same time, diarrhea is one of the most common gastrointestinal symptoms among infected people. As the debut of COVID-19 clinical manifestations, diarrhea can be associated both with the direct cytopathic effect of the virus on the intestinal mucosal epithelium and with the gut microbiota modulation. During the period of the expanded clinical picture of COVID-19, diarrhea syndrome is commonly associated with the adverse event of drug therapy, primarily antibiotics, nonsteroidal anti-inflammatory drugs, antiviral agents, antiplatelet agents and anticoagulants, as well as with possible involvement in the pathological process of the liver and pancreas with a violation of their functional activity. Finally, after the infection, the repeated occurrence of diarrhea requires the exclusion of antibiotic-associated diarrhea, including those caused by Clostridium difficile, as well as ischemic colitis and post-infectious irritable bowel syndrome. Besides, despite the pandemic, it should not be forgotten about the possible debut of gastrointestinal disorder or an exacerbation of already existing chronic pathology. The article presents a brief algorithm for the differential diagnosis of diarrhea in the conditions of the COVID-19 pandemic. KEYWORDS: diarrhea, COVID-19 pandemic, antibiotic-associated diarrhea, ischemic colitis, post-infectious irritable bowel syndrome. FOR CITATION: Gaus O.V., Livzan M.A. Diarrhea syndrome: new accents of patient curation during COVID-19 pandemic. Russian Medical Inquiry. 2021;5(6):446–452 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-446-452.

The human translation of the postinfectious irritable bowel syndrome like rat model with antivinculin production after immunization with cytolethal distending toxin B

2020 ◽  
Vol 33 (1) ◽  
Author(s):  
Max Schmulson ◽  
María Fernanda Davalos De la Rosa ◽  
Laura Linares‐Garcia ◽  
Alizon Sujey Morales‐Guzmán ◽  
Rita Balbuena ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Rat Model ◽  
Cytolethal Distending Toxin ◽  
Toxin B ◽  
Irritable Bowel ◽  
Postinfectious Irritable Bowel Syndrome

Frequency of subtypes of irritable bowel syndrome in positive and negative subtypes of schizophrenia

2016 ◽  
Vol 33 (S1) ◽  
pp. s240-s240
Author(s):  
S. Ahmed ◽  
G. Rasool
Keyword(s):  
Irritable Bowel Syndrome ◽  
Negative Symptoms ◽  
Gastrointestinal Disorder ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Language Version ◽  
Control Subjects ◽  
Axis I ◽  
Dsm Iv ◽  
Irritable Bowel

ObjectiveThe aim of the study was to determine the frequency of subtypes of irritable bowel syndrome in positive and negative subtypes of schizophrenia.MethodsSixty-two drug naïve hospitalized patients between 18 and 65 years (mean age: 33.6) with first episode of schizophrenia based on DSM IV-TR and 69 control subjects matched for age and sex completed this study. A semi-structured clinical interview was used to assess both groups. Clinical data were obtained and basic lab investigations and ultrasonography of abdomen were done in all subjects to exclude any related abdominal pathology. Axis-I disorders of DSM IV-TR were excluded in control subjects. Positive and Negative Syndrome Scale (PANSS) and Rome III Urdu language version scale (cross-validation obtained) for irritable bowel syndrome (IBS) were administered to assess the severity of positive and negative symptoms of schizophrenia and subtypes of irritable bowel syndrome, IBS constipation (IBS-C), IBS Diarrhoea (IBS-D) and IBS Mix (IBS-M) in case and control groups respectively.ResultsForty-seven patients (75.8%) and 15 patients (24.2%) had positive and negative schizophrenia respectively. Patients with positive and negative schizophrenia had higher rate of IBS-C 6.5% (n = 4), IBS-D 8.1% (n = 5), IBS-M 12.9% (n = 8), non-IBS 72.6% (n = 45) versus healthy subjects IBS-C 1.4% (n = 1), IBS-D 2.9% (n = 2), IBS-M 2.9% (n = 2), and non-IBS 92.8% (n = 64), OR = 4.8; 95% CI.ConclusionIrritable bowel syndrome is more frequent in patients with schizophrenia than in general population. This functional gastrointestinal disorder associated with psychotic symptoms requires attention and management while managing patients with subtypes of schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Assessment of Anti-vinculin and Anti-cytolethal Distending Toxin B Antibodies in Subtypes of Irritable Bowel Syndrome

2017 ◽  
Vol 62 (6) ◽  
pp. 1480-1485 ◽  
Author(s):  
Ali Rezaie ◽  
Sung Chul Park ◽  
Walter Morales ◽  
Emily Marsh ◽  
Anthony Lembo ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Cytolethal Distending Toxin ◽  
Toxin B ◽  
Irritable Bowel
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