scholarly journals Comparing the temporal relationship of structural and functional connectivity changes in different adult human brain networks: a single-case study

2018 ◽  
Vol 3 ◽  
pp. 50 ◽  
Author(s):  
Takamitsu Watanabe ◽  
Geraint Rees
Keyword(s):  
Functional Connectivity ◽  
Human Brain ◽  
Large Scale ◽  
Single Case ◽  
Brain Networks ◽  
Structural Connectivity ◽  
Time Lags ◽  
Single Case Study ◽  
Adult Human

Background: Despite accumulated evidence for adult brain plasticity, the temporal relationships between large-scale functional and structural connectivity changes in human brain networks remain unclear. Methods: By analysing a unique richly detailed 19-week longitudinal neuroimaging dataset, we tested whether macroscopic functional connectivity changes lead to the corresponding structural alterations in the adult human brain, and examined whether such time lags between functional and structural connectivity changes are affected by functional differences between different large-scale brain networks. Results: In this single-case study, we report that, compared to attention-related networks, functional connectivity changes in default-mode, fronto-parietal, and sensory-related networks occurred in advance of modulations of the corresponding structural connectivity with significantly longer time lags. In particular, the longest time lags were observed in sensory-related networks. In contrast, such significant temporal differences in connectivity change were not seen in comparisons between anatomically categorised different brain areas, such as frontal and occipital lobes. These observations survived even after multiple validation analyses using different connectivity definitions or using parts of the datasets. Conclusions: Although the current findings should be examined in independent datasets with different demographic background and by experimental manipulation, this single-case study indicates the possibility that plasticity of macroscopic brain networks could be affected by cognitive and perceptual functions implemented in the networks, and implies a hierarchy in the plasticity of functionally different brain systems.

scholarly journals Intersectional observations of the Human Brain Project’s approach to sex and gender

2019 ◽  
Vol 17 (2) ◽  
pp. 128-144
Author(s):  
B. Tyr Fothergill ◽  
William Knight ◽  
Bernd Carsten Stahl ◽  
Inga Ulnicane
Keyword(s):  
Human Brain ◽  
Large Scale ◽  
Single Case ◽  
Sex And Gender ◽  
Discursive Space ◽  
Content Type ◽  
Horizon 2020 ◽  
Representation Of Women ◽  
And Gender

Purpose This paper aims to critically assess approaches to sex and gender in the Human Brain Project (HBP) as a large information and communication technology (ICT) project case study using intersectionality. Design/methodology/approach The strategy of the HBP is contextualised within the wider context of the representation of women in ICT, and critically reflected upon from an intersectional standpoint. Findings The policy underpinning the approach deployed by the HBP in response to these issues parallels Horizon 2020 wording and emphasises economic outcomes, productivity and value, which aligns with other “equality” initiatives influenced by neoliberalised versions of feminism. Research limitations/implications Limitations include focussing on a single case study, the authors being funded as part of the Ethics and Society Subproject of the HBP, and the limited temporal period under consideration. Social implications The frameworks underpinning the HBP approach to sex and gender issues present risks with regard to the further entrenchment of present disparities in the ICT sector, may fail to acknowledge systemic inequalities and biases and ignore the importance of intersectionality. Shortcomings of the approach employed by the HBP up to March, 2018 included aspects of each of these risks, and replicated problematic understandings of sex, gender and diversity. Originality/value This paper is the first to use an intersectional approach to issues of sex and gender in the context of large-scale ICT research. Its value lies in raising awareness, opening a discursive space and presenting opportunities to consider and reflect upon potential, contextualised intersectional solutions to such issues.

scholarly journals Relationship of critical dynamics, functional connectivity, and states of consciousness in large-scale human brain networks

NeuroImage ◽  
2019 ◽  
Vol 188 ◽  
pp. 228-238 ◽  
Author(s):  
Heonsoo Lee ◽  
Daniel Golkowski ◽  
Denis Jordan ◽  
Sebastian Berger ◽  
Rüdiger Ilg ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Human Brain ◽  
Large Scale ◽  
Brain Networks ◽  
Critical Dynamics ◽  
States Of Consciousness ◽  
Relationship Of

scholarly journals Altered structural connectivity networks in dementia with lewy bodies

2021 ◽  
Author(s):  
Nicolas Nicastro ◽  
Elijah Mak ◽  
Ajenthan Surendranathan ◽  
Timothy Rittman ◽  
James B. Rowe ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Dementia With Lewy Bodies ◽  
Large Scale ◽  
Brain Networks ◽  
Structural Connectivity ◽  
Lewy Bodies ◽  
Occipital Lobe ◽  
Mri Imaging ◽  
Structural Networks ◽  
Graph Parameters

AbstractThe impairment of large-scale brain networks has been observed in dementia with Lewy bodies (DLB) using functional connectivity, but the potential for an analogous effect on structural covariance patterns has not been determined. Twenty-four probable DLB subjects (mean age 74.3 ± 6.7 years, 16.7% female) and 23 similarly aged Controls were included. All participants underwent 3T MRI imaging with high-resolution T1-weighted magnetization-prepared rapid gradient echo (MPRAGE) sequence. Graph theoretical analyses were performed using variation in regional cortical thickness to construct a structural association matrix with pairwise Pearson correlations. Global and nodal graph parameters were computed to assess between-group differences and community structure was studied in order to quantify large-scale brain networks in both groups. In comparison to Controls, DLB subjects had decreased global efficiency, clustering, modularity and small-worldness of structural networks (all p < 0.05). Nodal measures showed that DLB subjects also had decreased clustering in bilateral temporal regions and decreased closeness centrality in extensive areas including right middle frontal, left cingulate and bilateral occipital lobe (all false-discovery rate (FDR)-corrected q < 0.05). Whereas four distinct modules could be clearly identified in Controls, DLB showed extensively disorganized modules, including default-mode network and dorsal attentional network. Our results suggest a marked impairment in large-scale brain structural networks in DLB, mirroring functional connectivity networks disruption.

scholarly journals Visual imagery and functional connectivity in blindness: a single-case study

2015 ◽  
Vol 221 (4) ◽  
pp. 2367-2374 ◽  
Author(s):  
Christine C. Boucard ◽  
Josef P. Rauschecker ◽  
Susanne Neufang ◽  
Achim Berthele ◽  
Anselm Doll ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Visual Imagery ◽  
Single Case ◽  
Single Case Study

Metals and Metalla

2013 ◽  
Author(s):  
David J. Mattingly
Keyword(s):  
Natural Resources ◽  
Large Scale ◽  
Single Case ◽  
Mineral Resources ◽  
Mining Operation ◽  
Environmental Cost ◽  
Single Case Study ◽  
Metal Production ◽  
Landscape Survey

This chapter presents a single case study of a Roman imperial mining operation (metalla) as an example of the potential environmental and human consequences of large-scale Roman metal production. As such, it stands for many instances of Rome's exploitation of the key natural resources of provincial territories. Tacitus, for instance, was explicit in describing the mineral resources of Britain as the “spoils of victory.” However, it is shown that the consequences of Rome's pursuit of economic gain carried a high human and environmental cost. It draws on the results of the Wadi Faynan landscape survey (1996–2000), an interdisciplinary and diachronic investigation of evidence of environmental and climatic change, settlement pattern, and human activity.

Who Has Potatoes?

2003 ◽  
Vol 1 (2) ◽  
pp. 148-159
Author(s):  
Keith V. Bletzer
Keyword(s):  
Substance Use ◽  
Home Country ◽  
Single Case ◽  
Turning Points ◽  
Farm Labor ◽  
Single Case Study ◽  
Long Period ◽  
Migrant Work

Migratory farm labor like other forms of migrant work both in and outside agriculture impedes on the opportunity to make choices. The following essay explores particular phases in the life of one man (a single case study) and examines how he considers turning points in his life that led to a long period of substance use, both as an immigrant in the country and as a working man in his home country, followed by a cessation of use and the beginning stages of recovery. / Para el migrante, viajar en busca de trabajo es díficil, ya sea que trabaje en agricultura o en otras labores. Este ensayo examina ciertas etapas en la vida de un hombre (estudio de un solo caso) que examina los cambios que le han ocurrido durante un período en que él consumía grandes cantidades de alcohol en los estados y en su país, seguido por un período de sobriedad (no tomaba alcohol, no usaba drogas) en este país en que él comienza una etapa de rehabilitación.

Sign in / Sign up

Export Citation Format

Share Document