scholarly journals Ascertaining and classifying cases of congenital anomalies in the ALSPAC birth cohort

2020 ◽  
Vol 5 ◽  
pp. 231
Author(s):  
Kurt Taylor ◽  
Richard Thomas ◽  
Mark Mumme ◽  
Jean Golding ◽  
Andy Boyd ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Congenital Anomalies ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases ◽  
Functional Disorders ◽  
Multiple Sources ◽  
Health Records ◽  
Parents And Children ◽  
Avon Longitudinal Study

Congenital anomalies (CAs) are structural or functional disorders that occur during intrauterine life. Longitudinal cohort studies provide unique opportunities to investigate potential causes and consequences of these disorders. In this data note, we describe how we identified cases of major CAs, with a specific focus on congenital heart diseases (CHDs), in the Avon Longitudinal Study of Parents and Children (ALSPAC). We demonstrate that combining multiple sources of data including data from antenatal, delivery, primary and secondary health records, and parent-reported information can improve case ascertainment. Our approach identified 590 participants with a CA according to the Euro Registers of Congenital Anomalies (EUROCAT) guidelines, 127 of whom had a CHD. We describe the methods that identified these cases and provide statistics on subtypes of anomalies. The data note contains details on the processes required for researchers to access these data.

scholarly journals Ascertaining and classifying cases of congenital anomalies in the ALSPAC birth cohort

2021 ◽  
Vol 5 ◽  
pp. 231
Author(s):  
Kurt Taylor ◽  
Richard Thomas ◽  
Mark Mumme ◽  
Jean Golding ◽  
Andy Boyd ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Congenital Anomalies ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases ◽  
Functional Disorders ◽  
Multiple Sources ◽  
Health Records ◽  
Parents And Children ◽  
Avon Longitudinal Study

Congenital anomalies (CAs) are structural or functional disorders that occur during intrauterine life. Longitudinal cohort studies provide unique opportunities to investigate potential causes and consequences of these disorders. In this data note, we describe how we identified cases of major CAs, with a specific focus on congenital heart diseases (CHDs), in the Avon Longitudinal Study of Parents and Children (ALSPAC). We demonstrate that combining multiple sources of data including data from antenatal, delivery, primary and secondary health records, and parent-reported information can improve case ascertainment. Our approach identified 590 participants with a CA according to the European Surveillance of Congenital Anomalies (EUROCAT) guidelines, 127 of whom had a CHD. We describe the methods that identified these cases and provide statistics on subtypes of anomalies. The data note contains details on the processes required for researchers to access these data.

scholarly journals The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture November 2020 – March 2021

2021 ◽  
Vol 6 ◽  
pp. 155
Author(s):  
Daniel Smith ◽  
Claire Bowring ◽  
Nicholas Wells ◽  
Michael Crawford ◽  
Nicholas John Timpson ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Physical And Mental Health ◽  
Online Questionnaire ◽  
Health Records ◽  
Health Lifestyle ◽  
Parents And Children ◽  
Offspring Generation ◽  
Avon Longitudinal Study

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study has reacted rapidly and repeatedly to the coronavirus disease 2019 (COVID-19) pandemic, deploying online questionnaires throughout the pandemic. In November/December 2020, a fourth questionnaire was deployed asking about physical and mental health, lifestyle and behaviours, employment and finances. G0 participants were offered an online questionnaire between 17th November 2020 and 7th February 2021, while G1 participants were offered both online and paper questionnaires between 1st December 2020 and 19th March 2021. Of 15,844 invitations, 8,643 (55%) participants returned the questionnaire (3,101 original mothers [mean age 58.6 years], 1,172 original fathers/partners [mean age 61.5 years] and 4,370 offspring [mean age 28.4 years]). Of these 8,643 participants, 2,012 (23%) had not returned a previous COVID-19 questionnaire, while 3,575 (41%) had returned all three previous questionnaires. In this questionnaire, 300 participants (3.5%) reported a previous positive COVID-19 test, 110 (1.3%) had been told by a doctor they likely had COVID-19, and 759 (8.8%) suspected that they had had COVID-19. Based on self-reported symptoms, between October 2020 and February 2021 359 participants (4.2%) were predicted COVID-19 cases. COVID data is being complemented with linkage to health records and Public Health England pillar testing results as they become available. Data has been released as an update to the previous COVID-19 datasets. It comprises: 1) a standard dataset containing all participant responses to both questionnaires with key sociodemographic factors; and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study. This data note describes the fourth questionnaire and the data obtained from it.

scholarly journals The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture November 2020 – March 2021

2021 ◽  
Vol 6 ◽  
pp. 155
Author(s):  
Daniel Smith ◽  
Claire Bowring ◽  
Nicholas Wells ◽  
Michael Crawford ◽  
Nicholas John Timpson ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Physical And Mental Health ◽  
Online Questionnaire ◽  
Health Records ◽  
Health Lifestyle ◽  
Parents And Children ◽  
Offspring Generation ◽  
Avon Longitudinal Study

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study has reacted rapidly and repeatedly to the coronavirus disease 2019 (COVID-19) pandemic, deploying online questionnaires throughout the pandemic. In November/December 2020, a fourth questionnaire was deployed asking about physical and mental health, lifestyle and behaviours, employment and finances. G0 participants were offered an online questionnaire between 17th November 2020 and 7th February 2021, while G1 participants were offered both online and paper questionnaires between 1st December 2020 and 19th March 2021. Of 15,844 invitations, 8,643 (55%) participants returned the questionnaire (3,101 original mothers [mean age 58.6 years], 1,172 original fathers/partners [mean age 61.5 years] and 4,370 offspring [mean age 28.4 years]). Of these 8,643 participants, 2,012 (23%) had not returned a previous COVID-19 questionnaire, while 3,575 (41%) had returned all three previous questionnaires. In this questionnaire, 300 participants (3.5%) reported a previous positive COVID-19 test, 110 (1.3%) had been told by a doctor they likely had COVID-19, and 759 (8.8%) suspected that they had had COVID-19. Based on self-reported symptoms, between October 2020 and February 2021 359 participants (4.2%) were predicted COVID-19 cases. COVID data is being complemented with linkage to health records and Public Health England pillar testing results as they become available. Data has been released as an update to the previous COVID-19 datasets. It comprises: 1) a standard dataset containing all participant responses to both questionnaires with key sociodemographic factors; and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study. This data note describes the fourth questionnaire and the data obtained from it.

scholarly journals The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture May-July 2020

2020 ◽  
Vol 5 ◽  
pp. 210
Author(s):  
Kate Northstone ◽  
Daniel Smith ◽  
Claire Bowring ◽  
Nicholas Wells ◽  
Michael Crawford ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Physical And Mental Health ◽  
Online Questionnaire ◽  
Health Records ◽  
Health Lifestyle ◽  
Original Dataset ◽  
Parents And Children ◽  
Avon Longitudinal Study

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners and their offspring ever since. The study reacted rapidly to the coronavirus disease 2019 (COVID-19) pandemic, deploying an online questionnaire early on during lockdown (from 9th April to 15th May). In late May 2020, a second questionnaire was developed asking about physical and mental health, lifestyle and behaviours, employment and finances. The online questionnaire was deployed across the parent and offspring generations between the 26th May and 5th July 2020. 6482 participants completed the questionnaire (2639 original mothers, 1039 original fathers/partners, 2711 offspring (mean age ~28 years) and 93 partners of offspring). 1039 new participants who did not respond to the first questionnaire deployed in April completed the second questionnaire.  A positive COVID-19 was reported by 36 (0.6%) participants (12 G0 and 24 G1), 91 (1.4%; 35 G0 and 56 G1) reported that they had been told by a doctor they likely had COVID-19 and 838 (13%; 422 G0 and 416 G1) suspected that they have had COVID-19.  Using algorithmically estimated cases based on symptoms, we estimate that the predicted prevalence of COVID-19 from mid-April to time of questionnaire completion was 3.1%. Data from both COVID questionnaires will be complemented with linkage to health records and results of biological testing as they become available. Data has been released as an update to the original dataset released in May 2020. It comprises: 1) a standard dataset containing all participant responses to both questionnaires with key sociodemographic factors and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study. This data note describes the second questionnaire and the data obtained from it.

scholarly journals The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture April-May 2020

2020 ◽  
Vol 5 ◽  
pp. 127 ◽  
Author(s):  
Kate Northstone ◽  
Simown Howarth ◽  
Daniel Smith ◽  
Claire Bowring ◽  
Nicholas Wells ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Online Questionnaire ◽  
Health Records ◽  
Parents And Children ◽  
Seasonal Flu ◽  
The Impact ◽  
Avon Longitudinal Study

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992. The resource provides an informative and efficient setting for collecting data on the current coronavirus 2019 (COVID-19) pandemic. In early March 2020, a questionnaire was developed in collaboration with other longitudinal population studies to ensure cross-cohort comparability. It targeted retrospective and current COVID-19 infection information (exposure assessment, symptom tracking and reported clinical outcomes) and the impact of both disease and mitigating measures implemented to manage the COVID-19 crisis more broadly. Data were collected on symptoms of COVID-19 and seasonal flu, travel prior to the pandemic, mental health and social, behavioural and lifestyle factors. The online questionnaire was deployed across the parent and offspring generations between the 9th April and 15th May 2020. 6807 participants completed the questionnaire (2706 original mothers, 1014 original fathers/partners, 2973 offspring (mean age ~28 years) and 114 partners of offspring). Eight (0.01%) participants (4 G0 and 4 G1) reported a positive test for COVID-19, 77 (1.13%; 28 G0 and 49 G1) reported that they had been told by a doctor they likely had COVID-19 and 865 (12.7%; 426 G0 and 439 G1) suspected that they have had COVID-19.  Using algorithmically defined cases, we estimate that the predicted proportion of COVID-19 cases fell between 1.03% - 4.19% depending on timing of measurement during the period of reporting. Data from this first questionnaire will be complemented with at least two more follow-up questionnaires, linkage to health records and results of biological testing as they become available. Data has been released as: 1) a standard dataset containing all participant responses with key sociodemographic factors and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study.

Repairing the tricuspid valve in congenital heart diseases other than Ebstein’s

2014 ◽  
Vol 24 (6) ◽  
pp. 1077-1087
Author(s):  
Ali Dodge-Khatami ◽  
Constantine D. Mavroudis ◽  
Jennifer Frost ◽  
Jeffrey P. Jacobs ◽  
Constantine Mavroudis
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Tricuspid Valve ◽  
Congenital Anomalies ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Surgical Techniques ◽  
Congenital Heart Diseases ◽  
Right Heart ◽  
The Right

AbstractThe tricuspid valve is being increasingly recognised as an important safeguard to the heart with congenital heart disease. Both structural anomalies of the valve and functional burdens from other malformations of the right heart can lead to major haemodynamic consequences both upstream and downstream. The indications to surgically intervene on the tricuspid valve are evolving and vary depending on the malformation. The extant surgical techniques and their applications to corresponding frequent congenital anomalies of the tricuspid valve are reviewed.

scholarly journals Congenital Heart Diseases Associated with Congenital Anomalies of the Gastrointestinal Tract

2015 ◽  
Vol 31 (4) ◽  
pp. 192-198
Author(s):  
Tomohiro Nawa ◽  
Masato Yokozawa ◽  
Tsutomu Wada ◽  
Keiji Haseyama ◽  
Motoki Takamuro
Keyword(s):  
Gastrointestinal Tract ◽  
Congenital Anomalies ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases

scholarly journals Outcome of Patients having Congenital Anomalies of the Kidney and Urinary Tract Associated with Congenital Heart Diseases in Pediatric Cardiac ICU.

GEGET ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 34-48
Author(s):  
Amr Salem ◽  
Sonia El-Saiedi ◽  
Nevine Soliman ◽  
Ahmed Badr ◽  
Ahmed Hassan ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Congenital Anomalies ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases

scholarly journals The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture May-July 2020

2020 ◽  
Vol 5 ◽  
pp. 210 ◽  
Author(s):  
Kate Northstone ◽  
Daniel Smith ◽  
Claire Bowring ◽  
Nicholas Wells ◽  
Michael Crawford ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Sociodemographic Factors ◽  
Population Based ◽  
Physical And Mental Health ◽  
Online Questionnaire ◽  
Health Records ◽  
Health Lifestyle ◽  
Original Dataset ◽  
Parents And Children ◽  
Avon Longitudinal Study

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners and their offspring ever since. The study reacted rapidly to the coronavirus disease 2019 (COVID-19) pandemic, deploying an online questionnaire early on during lockdown (from 9th April to 15th May). In late May 2020, a second questionnaire was developed asking about physical and mental health, lifestyle and behaviours, employment and finances. The online questionnaire was deployed across the parent and offspring generations between the 26th May and 5th July 2020. 6482 participants completed the questionnaire (2639 original mothers, 1039 original fathers/partners, 2711 offspring (mean age ~28 years) and 93 partners of offspring). 1039 new participants who did not respond to the first questionnaire deployed in April completed the second questionnaire.  A positive COVID-19 test was reported by 36 (0.6%) participants (12 G0 and 24 G1), 91 (1.4%; 35 G0 and 56 G1) reported that they had been told by a doctor they likely had COVID-19 and 838 (13%; 422 G0 and 416 G1) suspected that they have had COVID-19.   The observational data from both COVID questionnaires will be complemented with linkage to health records and results of biological testing as they become available. In combination, these data may help us identify true cases. Data has been released as an update to the original dataset released in May 2020. It comprises: 1) a standard dataset containing all participant responses to both questionnaires with key sociodemographic factors and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study. This data note describes the second questionnaire and the data obtained from it.

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