scholarly journals Dose-response Relationship for Life-shortening and Carcinogenesis in Mice Irradiated at Day 7 Postnatal Age with Dose Range below 1 Gy of Gamma Rays

2006 ◽  
Vol 47 (2) ◽  
pp. 135-145 ◽  
Author(s):  
Shunsaku SASAKI ◽  
Nobuo FUKUDA
Keyword(s):  
Gamma Rays ◽  
Dose Response ◽  
Dose Range ◽  
Response Relationship ◽  
Dose Response Relationship

SENSITIVITY OF THE RAT TO INCREASING DOSES OF DEXTRAN

1962 ◽  
Vol 40 (6) ◽  
pp. 697-702 ◽  
Author(s):  
Gaetan Jasmin ◽  
Pierre Bois ◽  
Mai-Shian Su
Keyword(s):  
Toxic Effect ◽  
Intravenous Injection ◽  
Dose Response ◽  
Dose Range ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Toxic Dose ◽  
Lower Dose Range ◽  
Higher Doses ◽  
Adrenalectomized Rats

Increasing doses of dextran, a commercial 6% solution, were injected intravenously into both intact and adrenalectomized rats to evaluate the dose–response relationship. The minimum dose capable of producing an edema with 100% incidence was approximately 30 mg/kg in intact and only 4 mg/kg in adrenalectomized rats. Lower doses produced responses of decreasing intensity and incidence with a longer period of onset. Conversely, higher doses resulted in a shorter period of onset and a more intense reaction until a toxic dose was reached, beyond which cyanosis and shock appeared. Adrenalectomized rats reacted similarly to intact ones except that their response occurred at a lower dose range; they could not withstand the toxic effect of higher doses and died of circulatory failure. The fact reported by other workers that the edema is more intense and appears more rapidly after intravenous injection of minute rather than large quantities of dextran was not confirmed; the existence of a "critical dose" that does not produce any edema was not substantiated.

Fluoxetine seems to widen the nortriptyline antidepressant-like dose range in mice submitted to the tail suspension test (TST)

1992 ◽  
Vol 7 (1) ◽  
pp. 33-37
Author(s):  
IR de Oliveira ◽  
PR Brito ◽  
MF Peres ◽  
R Dardennes ◽  
MA da Rocha-Junior ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Dose Response ◽  
Dose Range ◽  
Tail Suspension Test ◽  
Response Relationship ◽  
Tail Suspension ◽  
Dose Response Relationship ◽  
High Doses ◽  
Higher Doses ◽  
Suspension Test

SummaryThis study was designed to verify whether fluoxetine (FL), a serotonin (5-HT) re-uptake inhibitor, would interfere with nortriptyline (NT), a biphasic U-shaped curvilinear dose-response relationship recently described in our laboratory. We associated 10 mg/kg NT or vehicle to 0, 5, 10, 20 and 40 mg/kg FL, in one group, and 10 mg FL or vehicle to 0, 5, 10, 20 and 40 mg/kg NT, in another group, 30 min before the tail suspension test (TST) in mice. Although we were not able to confirm a synergistic effect between FL and NT, FL-NT association seems to require higher doses of NT to block its own anti-immobility effect at high doses, thus widening NT effective antidepressant-like dose range in mice submitted to TST.

SENSITIVITY OF THE RAT TO INCREASING DOSES OF DEXTRAN

1962 ◽  
Vol 40 (1) ◽  
pp. 697-702 ◽  
Author(s):  
Gaetan Jasmin ◽  
Pierre Bois ◽  
Mai-Shian Su
Keyword(s):  
Toxic Effect ◽  
Intravenous Injection ◽  
Dose Response ◽  
Dose Range ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Toxic Dose ◽  
Lower Dose Range ◽  
Higher Doses ◽  
Adrenalectomized Rats

Increasing doses of dextran, a commercial 6% solution, were injected intravenously into both intact and adrenalectomized rats to evaluate the dose–response relationship. The minimum dose capable of producing an edema with 100% incidence was approximately 30 mg/kg in intact and only 4 mg/kg in adrenalectomized rats. Lower doses produced responses of decreasing intensity and incidence with a longer period of onset. Conversely, higher doses resulted in a shorter period of onset and a more intense reaction until a toxic dose was reached, beyond which cyanosis and shock appeared. Adrenalectomized rats reacted similarly to intact ones except that their response occurred at a lower dose range; they could not withstand the toxic effect of higher doses and died of circulatory failure. The fact reported by other workers that the edema is more intense and appears more rapidly after intravenous injection of minute rather than large quantities of dextran was not confirmed; the existence of a "critical dose" that does not produce any edema was not substantiated.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

Sign in / Sign up

Export Citation Format

Share Document