624 Poster A linear dose response relationship at a clinically relevant dose range exists for plasma citrulline levels after single dose whole body irradiation in mice

2002 ◽  
Vol 64 ◽  
pp. S192
Keyword(s):  
Single Dose ◽  
Dose Response ◽  
Dose Range ◽  
Whole Body ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Linear Dose ◽  
Plasma Citrulline ◽  
Relevant Dose

scholarly journals Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Dan-Hong Wei ◽  
Qi-Qi Mao
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Vitamin B12 ◽  
Dose Response ◽  
Vitamin B6 ◽  
Meta Analysis ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Pancreatic Cancer Risk ◽  
Linear Dose

Abstract Background Nutrients involved in one-carbon metabolism may play a key role in pancreatic carcinogenesis. The aim of this study was to examine the association between pancreatic cancer risk and intake or blood levels of vitamins B6, B12 and methionine via meta-analysis. Methods A systematic search was performed in PubMed, Web of Knowledge and Chinese National Knowledge Infrastructure (CNKI) up to April 2020 to identify relevant studies. Risk estimates and their 95% confidence intervals (CIs) were retrieved from the studies and combined by a random-effect model. Results A total of 18 studies were included in this meta-analysis on the association of vitamin B6, B12 and methionine with pancreatic cancer risk. The combined risk estimate (95% CI) of pancreatic cancer for the highest vs lowest category of vitamin B6 intake and blood pyridoxal 5′-phosphate (PLP, active form of vitamin B6) levels was 0.63 (0.48–0.79) and 0.65 (0.52–0.79), respectively. The results indicated a non-linear dose-response relationship between vitamin B6 intake and pancreatic risk. Linear dose–response relationship was found, and the risk of pancreatic cancer decreased by 9% for every 10 nmol/L increment in blood PLP levels. No significant association were found between pancreatic cancer risk and vitamin B12 intake, blood vitamin B12 levels, methionine intake and blood methionine levels. Conclusion Our study suggests that high intake of vitamin B6 and high concentration of blood PLP levels may be protective against the development of pancreatic cancer. Further research are warranted to confirm the results.

scholarly journals A dose–response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk

2015 ◽  
Vol 19 (8) ◽  
pp. 1446-1456 ◽  
Author(s):  
Nai-Hui Sun ◽  
Xuan-Zhang Huang ◽  
Shuai-Bo Wang ◽  
Yuan Li ◽  
Long-Yi Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dose Response ◽  
Meta Analysis ◽  
Dietary Vitamin ◽  
Vitamin B ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Total Vitamin ◽  
Linear Dose ◽  
Non Linear

AbstractObjectiveThe current meta-analysis evaluated the association between vitamin B12 intake and blood vitamin B12 level and colorectal cancer (CRC) risk.DesignThe PubMed and EMBASE databases were searched. A dose–response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values.SettingThe meta-analysis included seventeen studies.SubjectsA total of 10 601 patients.ResultsThe non-linear dose–response relationship between total vitamin B12 intake and CRC risk was insignificant (P=0·690), but the relationship between dietary vitamin B12 intake and CRC risk was significant (P<0·001). Every 4·5 μg/d increment in total and dietary vitamin B12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B12 intake and CRC risk was also significant when vitamin B12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose–response relationship between blood vitamin B12 level and CRC risk was insignificant (P=0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187).ConclusionsOur meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only.

SENSITIVITY OF THE RAT TO INCREASING DOSES OF DEXTRAN

1962 ◽  
Vol 40 (6) ◽  
pp. 697-702 ◽  
Author(s):  
Gaetan Jasmin ◽  
Pierre Bois ◽  
Mai-Shian Su
Keyword(s):  
Toxic Effect ◽  
Intravenous Injection ◽  
Dose Response ◽  
Dose Range ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Toxic Dose ◽  
Lower Dose Range ◽  
Higher Doses ◽  
Adrenalectomized Rats

Increasing doses of dextran, a commercial 6% solution, were injected intravenously into both intact and adrenalectomized rats to evaluate the dose–response relationship. The minimum dose capable of producing an edema with 100% incidence was approximately 30 mg/kg in intact and only 4 mg/kg in adrenalectomized rats. Lower doses produced responses of decreasing intensity and incidence with a longer period of onset. Conversely, higher doses resulted in a shorter period of onset and a more intense reaction until a toxic dose was reached, beyond which cyanosis and shock appeared. Adrenalectomized rats reacted similarly to intact ones except that their response occurred at a lower dose range; they could not withstand the toxic effect of higher doses and died of circulatory failure. The fact reported by other workers that the edema is more intense and appears more rapidly after intravenous injection of minute rather than large quantities of dextran was not confirmed; the existence of a "critical dose" that does not produce any edema was not substantiated.

The Thermoluminescence Response of Dy Doped Calcium Borate Glass Subjected to 6MV Photon Irradiation

2014 ◽  
Vol 895 ◽  
pp. 390-394 ◽  
Author(s):  
Hamiza Ahmad Tajuddin ◽  
Husin Wagiran ◽  
Rosli Hussin
Keyword(s):  
Dose Response ◽  
Borate Glass ◽  
Glass Sample ◽  
Dopant Concentration ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Melt Quenching ◽  
Photon Irradiation ◽  
Linear Dose ◽  
Quenching Method

This paper presents the thermoluminescence (TL) response and sensitivity of various dopant concentration of Dy into borate glass. Borates glass present absorption coefficient that closely to human bone and teeth. This fact makes borate as an ideal material for TL material either for medical or environmental dosimeter. Therefore, a series of glasses based on xCaO-(100-x)B2O3system (0 x 100) % weight has been prepared by using melt quenching method. In this research, Dy doped (0.01-0.4) mol% to 30CaO-70B2O3glass sample were studied to investigate the TL properties in terms of dose-response relationship and sensitivity. Samples were irradiated to various doses range 0.5-4.0 Gy subjected to 6 MV photon irradiation by using LINAC Primus MLC 3339. The TL intensity of various dopant concentration were studied and it was founds that the 0.3 mol% Dy has the highest TL response and has linear dose response relationship. The highest sensitivity was calculated as 58 nC.mg-1.Gy-1for 0.3 mol% Dy concentration.

Fluoxetine seems to widen the nortriptyline antidepressant-like dose range in mice submitted to the tail suspension test (TST)

1992 ◽  
Vol 7 (1) ◽  
pp. 33-37
Author(s):  
IR de Oliveira ◽  
PR Brito ◽  
MF Peres ◽  
R Dardennes ◽  
MA da Rocha-Junior ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Dose Response ◽  
Dose Range ◽  
Tail Suspension Test ◽  
Response Relationship ◽  
Tail Suspension ◽  
Dose Response Relationship ◽  
High Doses ◽  
Higher Doses ◽  
Suspension Test

SummaryThis study was designed to verify whether fluoxetine (FL), a serotonin (5-HT) re-uptake inhibitor, would interfere with nortriptyline (NT), a biphasic U-shaped curvilinear dose-response relationship recently described in our laboratory. We associated 10 mg/kg NT or vehicle to 0, 5, 10, 20 and 40 mg/kg FL, in one group, and 10 mg FL or vehicle to 0, 5, 10, 20 and 40 mg/kg NT, in another group, 30 min before the tail suspension test (TST) in mice. Although we were not able to confirm a synergistic effect between FL and NT, FL-NT association seems to require higher doses of NT to block its own anti-immobility effect at high doses, thus widening NT effective antidepressant-like dose range in mice submitted to TST.

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