scholarly journals A Case of Gitelman Syndrome that Was Difficult to Distinguish from Hypokalemic Periodic Paralysis Caused by Graves' Disease

2019 ◽  
Vol 86 (5) ◽  
pp. 301-306
Author(s):  
Takeshi Oba ◽  
Shunsuke Kobayashi ◽  
Yuko Nakamura ◽  
Mototsugu Nagao ◽  
Kandai Nozu ◽  
...  
Keyword(s):  
Periodic Paralysis ◽  
Gitelman Syndrome ◽  
Graves Disease ◽  
Hypokalemic Periodic Paralysis

An Unusual Presentation of Short Stature With Childhood Hypokalemic Periodic Paralysis Due to Gitelman Syndrome

2009 ◽  
Vol 19 (4) ◽  
pp. 167-168
Author(s):  
Shrikrishna V. Acharya ◽  
Raju A. Gopal ◽  
Padma S. Menon ◽  
Tushar R. Bandgar ◽  
Nalini S. Shah
Keyword(s):  
Short Stature ◽  
Periodic Paralysis ◽  
Gitelman Syndrome ◽  
Unusual Presentation ◽  
Hypokalemic Periodic Paralysis

Thyrotoxic, hypokalemic periodic paralysis (THPP) in adolescents

2015 ◽  
Vol 28 (1-2) ◽  
Author(s):  
Hiba Al-Zubeidi ◽  
Carla Demeterco ◽  
Kenneth Lee Jones
Keyword(s):  
Chart Review ◽  
Periodic Paralysis ◽  
Pediatric Care ◽  
Graves Disease ◽  
Childhood And Adolescence ◽  
Care Providers ◽  
Hypokalemic Periodic Paralysis ◽  
The Third ◽  
The Usa ◽  
Thyrotoxic Hypokalemic Periodic Paralysis

AbstractPeriodic paralysis associated with hyperthyroidism and hypokalemia is an uncommon disorder reported primarily in Asian males and rarely in children. We report three Hispanic adolescent males who were seen with Graves’ disease (GD) and THPP.The method used was chart review.Two of these boys presented with episodes of paralysis and were diagnosed with GD. The third was initially seen with hyperthyroidism and developed weakness and paralysis when his disease progressed because of therapeutic noncompliance. Hypokalemia was documented in two of the three patients with the third not seen during paralysis. Intravenous KTHPP is considered uncommon except in Asian males and rare in childhood and adolescence. Its occurrence in these three Hispanic boys suggests that it may occur more frequently in the young and in the USA than has been suspected, especially with the changing national demographics. We believe that our experience should raise the awareness of THPP among pediatric care providers.

scholarly journals SUN-518 Graves’ Disease Newly Diagnosed in the Setting of Hypokalemic Periodic Paralysis in an HIV+ Patient

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Emily V Nosova ◽  
Emily Japp ◽  
Sheldon T Brown ◽  
Alan J Cohen ◽  
Pietra D Greenberg
Keyword(s):  
African American ◽  
Case Report ◽  
Thyroid Disease ◽  
Sudden Onset ◽  
Periodic Paralysis ◽  
Graves Disease ◽  
Thyroid Function Tests ◽  
Hypokalemic Periodic Paralysis ◽  
10Mg Daily ◽  
First Case

Abstract Relevance: A rare yet distinct cause of sudden onset paralysis is severe hypokalemia associated with thyrotoxicosis. This is thought to be associated with mutations in genes encoding cellular potassium channels. We report a case of acute onset paralysis with profound hypokalemia and a new diagnosis of Graves’ thyrotoxicosis in a previously asymptomatic African American, HIV+ man on highly active antiretroviral therapy (HAART) for over 8 years. Clinical case: A 49-year-old man with hypertension and HIV presented with acute paralysis of his bilateral upper and lower extremities. His initial potassium was 1.8 mEq/L (3.5-5.0). Prior to sudden onset loss of motor strength, he denied any preceding palpitations, tremor, anxiety, diaphoresis, hyper-defecation, weight loss, heat or cold intolerance, neck pain, increase in neck girth or difficulty swallowing, proptosis or other ocular symptoms. He has no family history of thyroid disease. He had an enlarged palpable thyroid without nodules and no audible bruit. There was no periorbital edema or proptosis, and no signs of dermopathy. A thyroid ultrasound showed a hyperemic and diffusely enlarged thyroid gland without nodules. Labs included a TSH of 0.007 mCU/mL (0.43-3.8), Free T4 2.1 ng/dL (0.71-1.85), Total T3 229.6 ng/dL (58-194), and thyrotropin receptor antibody 2.6 IU/L (0-1.75). The CD4+ count was 146 in 2010 with a slow gradual rise to 673 in 2019, and HIV viral load was undetectable. There were no offending medications or supplements identified. With aggressive potassium repletion, the serum potassium improved to 4.6 mEq/L and he regained normal strength within several hours. He was started on Methimazole 10mg daily and propranolol 10mg TID. At one month, the thyroid function tests normalized. Methimazole 10mg daily was continued and propranolol was tapered off. He remains euthyroid. Genetic testing is pending. Conclusions: Graves’ disease is the most common thyroid disease triggered by immune reconstitution in HIV + individuals on HAART. The incidence of thyroid disease in HIV patients on HAART is higher in women and Africans with a 1.5-2 fold increase compared with the general population [Muller et. al, Eur Thyroid J 2019;8:173-185]. Despite a higher incidence of hyperthyroidism in women, over 95% of cases of hypokalemic periodic paralysis have been reported in men, with a 10-fold higher incidence among Asians compared to Westerners. There has been one prior case report of Thyrotoxic Periodic Paralysis in an HIV + patient and this was in a Polynesian male (Brown JD et al. Hawaii Med J 2007). To our knowledge, this is the first case report of an African American HIV+ patient with this disorder. An association with mutations in the Kir2.6 gene (encodes a potassium channel, is expressed in skeletal muscle, and is transcriptionally regulated by thyroid hormone) has been proposed [Ryan et. al, Cell 2010 January 8; 140(1):88-98].

Hypokalemic Periodic Paralysis due to Graves Disease

2009 ◽  
Vol 122 (12) ◽  
pp. e5-e6
Author(s):  
Alexandra Drakaki ◽  
Muzzamal Habib ◽  
Ann T. Sweeney
Keyword(s):  
Periodic Paralysis ◽  
Graves Disease ◽  
Hypokalemic Periodic Paralysis

Unilateral Gynecomastia and Hypokalemic Periodic Paralysis as First Manifestations of Graves’ Disease

2013 ◽  
Vol 345 (6) ◽  
pp. 504-506 ◽  
Author(s):  
Yufan Wang ◽  
Li Zhao ◽  
Fang Fang ◽  
Yong-de Peng ◽  
Fan Li ◽  
...  
Keyword(s):  
Periodic Paralysis ◽  
Graves Disease ◽  
Hypokalemic Periodic Paralysis

Thyrotoxic Hypokalemic Periodic Paralysis as the First Manifestation of Interferon-?????induced Graves Disease

2006 ◽  
Vol 40 (9) ◽  
pp. 863-865 ◽  
Author(s):  
Mustafa Cesur ◽  
Alptekin Gursoy ◽  
Ufuk Avcioglu ◽  
Murat Faik Erdogan ◽  
Demet Corapcioglu ◽  
...  
Keyword(s):  
Periodic Paralysis ◽  
Graves Disease ◽  
Hypokalemic Periodic Paralysis ◽  
Thyrotoxic Hypokalemic Periodic Paralysis
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