Study of Analgesic Intake among Patients with Chronic Low Back Pain and Their Side Effects

2017 ◽  
Vol 69 (3) ◽  
pp. 2128-2132
Author(s):  
Molook Shebeeb Alotibi ◽  
Abdullah Ibrahim Saeed ◽  
Hussam Sunaid Dhaher Almuzaini
Author(s):  
G N Vasilieva ◽  
A L Linkov ◽  
N O Kukushkina ◽  
F I Dimitrienko ◽  
A E Karelov

Effectiveness of different methods of analgesia was studied in 34 aged patients suffering chronic low back pain. All patients were at age 60 to 86 and were randomized into N-group in which nefopam (60 mg rectally) was administrated and K-group that included patients who received ketoprofen (100 mg rectally). The end-points of this prospective study were decrease of pain intensity after analgesics administration, contentment of therapy, and characteristics of side effects of medications taking (twice daily for three days). We found that pain intensity decreases by 6,3±1,6 in N-group and 6,1±1,3 in K- group (p<0.05 in the both cases) and achieves 0,9±1,4 and 0,9±1,6 in N- and in K-group, respectively (p>0.05 in comparison between groups). No significant differences between groups were in estimation of therapy contentment. No side effects were registered. Thus, our data proved the equal effectiveness of central nonopioid analgesic nefopam and nonselective cyclooxygenise inhibitor ketoprofen for achievement of good analgesia in aged patients with chronic low back pain.


2019 ◽  
Vol 26 (6) ◽  
pp. 1019-1026 ◽  
Author(s):  
K. Pavelka ◽  
H. Jarosova ◽  
O. Sleglova ◽  
R. Svobodova ◽  
M. Votavova ◽  
...  

Chronic low back pain (CLBP) syndrome represents one of the leading causes of long-term disability worldwide. The prevalence of CLBP has been rising significantly in relation to increasing average life expectancy. CLBP results from chronification of acute low back pain. There are many factors contributing to the CLBP crisis; common etiopathogenetic factors include e.g., functional blockage of intervertebral joints. The treatment of CLBP is complex. An important part of treatment consists of pain pharmacotherapy, for which several groups of drugs are used. The problem lies in the side effects of many of these traditionally used medications. Therefore, new and safer treatment methods are being sought. Innovative options for CLBP pharmacology include injections containing collagen, which can be combined with other traditionally used drugs, which helps reduce dosages and increase the overall safety of CLBP therapy.


Author(s):  
Andrew H. Rogers ◽  
Lorra Garey ◽  
Amanda M. Raines ◽  
Nicholas P. Allan ◽  
Norman B. Schmidt ◽  
...  

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