From the Editor—Special Cluster on High-Throughput Optimization

We describe, for the first time, the use of fast neutron irradiation for the rapid metabolic optimization of an oleaginous yeast. The approach established in this study provides a progressive path towards automatable strain development efforts.

Download Full-text

High-throughput optimization of the chemically defined synthetic medium for the production of erythromycin A

Bioprocess and Biosystems Engineering ◽

10.1007/s00449-018-1980-6 ◽

2018 ◽

Vol 41 (10) ◽

pp. 1529-1538

Author(s):

Ming Hong ◽

Jianguo Liao ◽

Ju Chu

Keyword(s):

High Throughput ◽

Synthetic Medium ◽

Throughput Optimization ◽

Erythromycin A

Download Full-text

Fabrication of spin-frustrated Sm2Mo2O7 epitaxial films: High throughput optimization using a temperature gradient method

Applied Physics Letters ◽

10.1063/1.1559440 ◽

2003 ◽

Vol 82 (10) ◽

pp. 1571-1573 ◽

Cited By ~ 9

Author(s):

J. Nishimura ◽

T. Fukumura ◽

M. Ohtani ◽

Y. Taguchi ◽

M. Kawasaki ◽

...

Keyword(s):

Temperature Gradient ◽

High Throughput ◽

Gradient Method ◽

Epitaxial Films ◽

Throughput Optimization ◽

Temperature Gradient Method

Download Full-text

High-Throughput Optimization of Ir-Catalyzed C–H Borylation: A Tutorial for Practical Applications

Journal of the American Chemical Society ◽

10.1021/ja400295v ◽

2013 ◽

Vol 135 (20) ◽

pp. 7572-7582 ◽

Cited By ~ 130

Author(s):

Sean M. Preshlock ◽

Behnaz Ghaffari ◽

Peter E. Maligres ◽

Shane W. Krska ◽

Robert E. Maleczka ◽

...

Keyword(s):

High Throughput ◽

Throughput Optimization ◽

Practical Applications

Download Full-text

Microreactor Chemical Bath Deposition of Laterally Graded Cd1–xZnxS Thin Films: A Route to High-Throughput Optimization for Photovoltaic Buffer Layers

Chemistry of Materials ◽

10.1021/cm3023506 ◽

2013 ◽

Vol 25 (3) ◽

pp. 297-306 ◽

Cited By ~ 20

Author(s):

Kevin M. McPeak ◽

Borirak Opasanont ◽

Tomohiro Shibata ◽

Dong-Kyun Ko ◽

Matthew A. Becker ◽

...

Keyword(s):

Thin Films ◽

Chemical Bath Deposition ◽

High Throughput ◽

Buffer Layers ◽

Throughput Optimization

Download Full-text

Droplet Microfluidics: High‐Throughput Optimization of Recombinant Protein Production in Microfluidic Gel Beads (Small 2/2021)

Small ◽

10.1002/smll.202170004 ◽

2021 ◽

Vol 17 (2) ◽

pp. 2170004

Author(s):

Marta Napiorkowska ◽

Luzius Pestalozzi ◽

Sven Panke ◽

Martin Held ◽

Steven Schmitt

Keyword(s):

Recombinant Protein ◽

High Throughput ◽

Recombinant Protein Production ◽

Protein Production ◽

Droplet Microfluidics ◽

Throughput Optimization ◽

Gel Beads

Download Full-text

Development of Combinatorial Chemistry Methods for Coatings: High-Throughput Optimization of Curing Parameters of Coatings Libraries

Analytical Chemistry ◽

10.1021/ac025710x ◽

2002 ◽

Vol 74 (21) ◽

pp. 5676-5680 ◽

Cited By ~ 23

Author(s):

Radislav A. Potyrailo ◽

Daniel R. Olson ◽

George Medford ◽

Michael J. Brennan

Keyword(s):

High Throughput ◽

Combinatorial Chemistry ◽

Throughput Optimization

Download Full-text

High-throughput experimentation applied to atom transfer radical polymerization: Automated optimization of the copper catalysts removal from polymers

e-Polymers ◽

10.1515/epoly.2006.6.1.90 ◽

2006 ◽

Vol 6 (1) ◽

Cited By ~ 5

Author(s):

Huiqi Zhang ◽

Caroline H. Abeln ◽

Martin W. M. Fijten ◽

Ulrich S. Schubert

Keyword(s):

Atom Transfer Radical Polymerization ◽

Radical Polymerization ◽

High Throughput ◽

Copper Catalysts ◽

Atom Transfer ◽

Throughput Optimization ◽

Polymer Science ◽

Molecular Weights ◽

High Throughput Experimentation ◽

Automated Optimization

AbstractCombinatorial chemistry and high-throughput experimentation have drawn great attention in recent years because of their significant advantages in increasing the research productivity. One of the emerging fields is their application in polymer science. Herein we describe the high-throughput optimization of purification conditions for polymers prepared via atom transfer radical polymerization using an automated synthesizer. The effects of the column materials, column lengths and eluent volumes on the purification efficiency as well as the molecular weights of the obtained purified polymers were systematically investigated for the first time. The optimum purification conditions for the removal of copper catalysts are provided. As a result an online high-throughput purification workflow using SPE cartridges is now available for the utilization in automated parallel synthesizers for ATRP screening experiment.

Download Full-text