Health Effects Of Non-Occupational Exposure To Oil Extraction Industry: A Prevalent But Poorly Studied Risk

2015 ◽  
Vol 2015 (1) ◽  
pp. 2005
Author(s):  
Cristina O'Callaghan Gordo ◽  
Martí Orta Martínez ◽  
Manolis Kogevinas
2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Cristina O’Callaghan-Gordo ◽  
Martí Orta-Martínez ◽  
Manolis Kogevinas

Author(s):  
Nektarios Karanikas ◽  
Cherry Foster ◽  
Adolfo Beltran Hernandez ◽  
Alice Harvey ◽  
Ozan Targal ◽  
...  

2019 ◽  
Vol 28 (15) ◽  
pp. 2477-2485 ◽  
Author(s):  
Diana A van der Plaat ◽  
Judith M Vonk ◽  
Natalie Terzikhan ◽  
Kim de Jong ◽  
Maaike de Vries ◽  
...  

Abstract Many workers are daily exposed to occupational agents like gases/fumes, mineral dust or biological dust, which could induce adverse health effects. Epigenetic mechanisms, such as DNA methylation, have been suggested to play a role. We therefore aimed to identify differentially methylated regions (DMRs) upon occupational exposures in never-smokers and investigated if these DMRs associated with gene expression levels. To determine the effects of occupational exposures independent of smoking, 903 never-smokers of the LifeLines cohort study were included. We performed three genome-wide methylation analyses (Illumina 450 K), one per occupational exposure being gases/fumes, mineral dust and biological dust, using robust linear regression adjusted for appropriate confounders. DMRs were identified using comb-p in Python. Results were validated in the Rotterdam Study (233 never-smokers) and methylation-expression associations were assessed using Biobank-based Integrative Omics Study data (n = 2802). Of the total 21 significant DMRs, 14 DMRs were associated with gases/fumes and 7 with mineral dust. Three of these DMRs were associated with both exposures (RPLP1 and LINC02169 (2×)) and 11 DMRs were located within transcript start sites of gene expression regulating genes. We replicated two DMRs with gases/fumes (VTRNA2-1 and GNAS) and one with mineral dust (CCDC144NL). In addition, nine gases/fumes DMRs and six mineral dust DMRs significantly associated with gene expression levels. Our data suggest that occupational exposures may induce differential methylation of gene expression regulating genes and thereby may induce adverse health effects. Given the millions of workers that are exposed daily to occupational exposures, further studies on this epigenetic mechanism and health outcomes are warranted.


2020 ◽  
Vol 27 (18) ◽  
pp. 22251-22270
Author(s):  
Patrick Amoatey ◽  
Ahmed Al-Mayahi ◽  
Hamid Omidvarborna ◽  
Mahad Said Baawain ◽  
Hameed Sulaiman

Chemosphere ◽  
2014 ◽  
Vol 104 ◽  
pp. 25-31 ◽  
Author(s):  
M. Jumpponen ◽  
H. Rönkkömäki ◽  
P. Pasanen ◽  
J. Laitinen

Sign in / Sign up

Export Citation Format

Share Document