scholarly journals Differential Kinetic Activities of Glycerol Kinase among African Trypanosome Species: Phylogenetic and Therapeutic Implications

2011 ◽  
Vol 73 (5) ◽  
pp. 615-621 ◽  
Author(s):  
Mitsuko OHASHI-SUZUKI ◽  
Yoshisada YABU ◽  
Shigeru OHSHIMA ◽  
Kosuke NAKAMURA ◽  
Yasutoshi KIDO ◽  
...  
Keyword(s):  
Glycerol Kinase ◽  
Trypanosome Species ◽  
African Trypanosome ◽  
Therapeutic Implications

scholarly journals Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Harriet Lane-Serff ◽  
Paula MacGregor ◽  
Lori Peacock ◽  
Olivia JS Macleod ◽  
Christopher Kay ◽  
...  
Keyword(s):  
Developmental Stage ◽  
Trypanosoma Brucei ◽  
Evolutionary History ◽  
Trypanosoma Congolense ◽  
Tsetse Fly ◽  
Mammalian Host ◽  
Trypanosome Species ◽  
African Trypanosome ◽  
Evolutionary Diversification ◽  
Cellular Changes

The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense receptor in complex with haemoglobin. This allows us to propose an evolutionary history for this receptor, charting the structural and cellular changes that took place as it adapted from a role in the insect to a new role in the mammalian host.

A PCR based assay for detection and differentiation of African trypanosome species in blood

2005 ◽  
Vol 111 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Andrew Cox ◽  
Aimee Tilley ◽  
Francis McOdimba ◽  
Jenna Fyfe ◽  
Mark Eisler ◽  
...  
Keyword(s):  
Trypanosome Species ◽  
African Trypanosome

Analysis of host genetic factors influencing African trypanosome species infection in a cohort of Tanzanian Bos indicus cattle

2011 ◽  
Vol 179 (1-3) ◽  
pp. 35-42 ◽  
Author(s):  
Esron D. Karimuribo ◽  
Liam J. Morrison ◽  
Alana Black ◽  
C. Michael R. Turner ◽  
Dominic M. Kambarage ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Bos Indicus ◽  
Trypanosome Species ◽  
African Trypanosome ◽  
Factors Influencing ◽  
Host Genetic ◽  
Host Genetic Factors

scholarly journals Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species

2012 ◽  
Vol 109 (9) ◽  
pp. 3416-3421 ◽  
Author(s):  
A. P. Jackson ◽  
A. Berry ◽  
M. Aslett ◽  
H. C. Allison ◽  
P. Burton ◽  
...  
Keyword(s):  
Trypanosome Species ◽  
Evolutionary Mechanisms ◽  
Antigenic Diversity ◽  
African Trypanosome
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