The role of the inflammatory response in chronic bronchitis: Therapeutic implications

2000 ◽  
Vol 15 (1) ◽  
pp. 24-31 ◽  
Author(s):  
S NELSON
Keyword(s):  
Inflammatory Response ◽  
Chronic Bronchitis ◽  
Therapeutic Implications

scholarly journals Platelets Are Critical Key Players in Sepsis

2019 ◽  
Vol 20 (14) ◽  
pp. 3494 ◽  
Author(s):  
Fanny Vardon-Bounes ◽  
Stéphanie Ruiz ◽  
Marie-Pierre Gratacap ◽  
Cédric Garcia ◽  
Bernard Payrastre ◽  
...  
Keyword(s):  
Immune Response ◽  
Endothelial Cells ◽  
Inflammatory Response ◽  
Host Defense ◽  
Critical Role ◽  
Therapeutic Implications ◽  
Key Players

Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet–pathogens interactions. The critical role of platelets during sepsis and the therapeutic implications are also reviewed.

Novel Mechanisms for Resolution of Liver Inflammation: Therapeutic Implications

2021 ◽  
Author(s):  
Benedikt Kaufmann ◽  
Agustina Reca ◽  
Andrea D. Kim ◽  
Ariel E. Feldstein
Keyword(s):  
Inflammatory Response ◽  
Adaptive Immune System ◽  
Hepatic Function ◽  
New Paradigm ◽  
Therapeutic Implications ◽  
Adaptive Immune ◽  
Disease States ◽  
Insight Into ◽  
Stimulation Of

AbstractTraditional concepts have classically viewed resolution of inflammation as a passive process yet insight into the pathways by which inflammation is resolved has challenged this idea. Resolution has been revealed as a highly dynamic and active event that is essential to counteract the dysregulated inflammatory response that drives diverse disease states. Abrogation of the hepatic inflammatory response through the stimulation of proresolving mechanisms represents a new paradigm in the setting of chronic inflammatory-driven liver diseases. Elucidation of the role of different cells of the innate and adaptive immune system has highlighted the interplay between them as an important orchestrator of liver repair. A finely tuned interaction between neutrophils and macrophages has risen as revolutionary mechanism that drives the restoration of hepatic function and architecture. Specialized proresolving mediators have also been shown to act as stop signals of the inflammatory response and promote resolution as well as tissue regeneration. In this review, we discuss the discovery and understanding of the mechanisms by which inflammation is resolved and highlight novel proresolving pathways that represent promising therapeutic strategies.

The role of microRNA regulation in the early inflammatory response: miR-146a and NF-κB signaling in lung inflammation

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
X Lai ◽  
C Schulz ◽  
F Seifert ◽  
B Dolniak ◽  
O Wolkenhauer ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lung Inflammation ◽  
Microrna Regulation ◽  
Early Inflammatory Response

The role of microRNA regulation in the early inflammatory response: miR-146a and NF-κB signaling in lung inflammation

Pneumologie ◽  
2014 ◽  
Vol 68 (02) ◽  
Author(s):  
C Schulz ◽  
X Lai ◽  
F Seifert ◽  
O Wolkenhauer ◽  
J Vera ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lung Inflammation ◽  
Microrna Regulation ◽  
Early Inflammatory Response

Role of melatonin in regulating neurogenesis: Implications for the neurodegenerative pathology and analogous therapeutics for Alzheimer’s disease

2020 ◽  
Vol 3 (2) ◽  
pp. 216-242 ◽  
Author(s):  
Mayuri Shukla ◽  
Areechun Sotthibundhu ◽  
Piyarat Govitrapong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Adult Neurogenesis ◽  
Adult Brain ◽  
Therapeutic Approaches ◽  
Therapeutic Implications ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Progenitor Cell Proliferation

The revelation of adult brain exhibiting neurogenesis has established that the brain possesses great plasticity and that neurons could be spawned in the neurogenic zones where hippocampal adult neurogenesis attributes to learning and memory processes. With strong implications in brain functional homeostasis, aging and cognition, various aspects of adult neurogenesis reveal exuberant mechanistic associations thereby further aiding in facilitating the therapeutic approaches regarding the development of neurodegenerative processes in Alzheimer’s Disease (AD). Impaired neurogenesis has been significantly evident in AD with compromised hippocampal function and cognitive deficits. Melatonin the pineal indolamine augments neurogenesis and has been linked to AD development as its levels are compromised with disease progression. Here, in this review, we discuss and appraise the mechanisms via which melatonin regulates neurogenesis in pathophysiological conditions which would unravel the molecular basis in such conditions and its role in endogenous brain repair. Also, its components as key regulators of neural stem and progenitor cell proliferation and differentiation in the embryonic and adult brain would aid in accentuating the therapeutic implications of this indoleamine in line of prevention and treatment of AD.   

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