scholarly journals Liver abscess production in mice by intraportal injection of Fusobacterium necrophorum biovar a strain.

1981 ◽  
Vol 43 (6) ◽  
pp. 919-921 ◽  
Author(s):  
Toshiharu SHINJO ◽  
Makoto YOSHITAKE ◽  
Hiroko KIYOYAMA ◽  
Naoaki MISAWA ◽  
Kazuo UCHIDA
2013 ◽  
Vol 62 (11) ◽  
pp. 1755-1759 ◽  
Author(s):  
Kentaro Nagaoka ◽  
Katsunori Yanagihara ◽  
Yosuke Harada ◽  
Koichi Yamada ◽  
Yohei Migiyama ◽  
...  

Anaerobic bacterial infection is often accompanied by abscess formation; however, few in vivo studies have been published with descriptive data specifically evaluating antimicrobial activity in the presence of abscesses. The aim of this study was to establish a murine model of anaerobic infection with abscess formation and to verify the utility of this model for evaluating the in vivo efficacy of an antimicrobial agent. A clinical isolate of Fusobacterium necrophorum was inoculated into the caudal vein of immunocompetent BALB/c mice at 108 c.f.u. per mouse. Changes in body weight, bacterial load and histopathology of key organs were evaluated. After inoculation, bacterial counts in the liver increased from 104 to 108 c.f.u. after 1–3 days, and liver abscess formation was observed on the day following infection. Abscess formation and bacterial growth were not observed in other organs. In this model, 3 days of treatment with 5 mg metronidazole kg−1 eradicated F. necrophorum in the liver; however, a reduction in bacterial load was not observed with 0.05 mg metronidazole kg−1. In this study, we established a novel murine model of F. necrophorum liver abscess via haematogenous infection that may be useful for investigating in vivo antimicrobial activity against anaerobic abscesses and understanding the pathogenesis of F. necrophorum infection.


2011 ◽  
Vol 50 (17) ◽  
pp. 1815-1819 ◽  
Author(s):  
Yuichi Nozawa ◽  
Satoru Joshita ◽  
Mana Fukushima ◽  
Yukiko Sugiyama ◽  
Yuki Ichikawa ◽  
...  

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 212-212
Author(s):  
Kelton Adair ◽  
Samodha Fernando ◽  
Galen E Erickson ◽  
Alison Bartenslager ◽  
Zachary E Carlson

Abstract A feedlot study was conducted comparing the effects of a direct-fed microbial feed additive (DFM) to no feed additive (CON) on performance and liver abscess rates in finishing beef cattle. The study utilized 60 crossbred steers (initial BW 274 kg ± 2.23) individually fed using a Calan gate system. Steers were housed in separate pens by treatment to avoid DFM cross-contamination, with pen (barn of 30 steers) assigned randomly to each treatment. Cattle were fed a diet consisting of 15% corn silage, 36.5% high moisture corn, 24.5% dry rolled corn, 20% modified distillers grains, and 4% supplement for 189 days. The DFM counts were estimated using cell cytometry and was top dressed at a concentration of approximately 81 billion bacterial cells/head/day. The DFM additive used in this study was developed to reduce the abundance of Fusobacterium necrophorum and Streptococcus bovis in the rumen. No effect of treatment on hot carcass weight (HCW), average daily gain (ADG), dry matter intake (DMI), feed efficiency (G:F), or carcass traits (Table 1) were observed. No significant difference in the occurrence of liver abscesses between treatment groups were observed with 4 steers having abscessed livers in the CON group and 3 steers in the DFM group. Additionally, there were no differences in the severity of liver abscesses; all observed liver abscesses received the score of A. The DFM utilized in this study did not significantly affect performance, liver abscess rate, or the severity of liver abscesses in finishing beef cattle.


2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Natasa Radovanovic ◽  
Igor Dumic ◽  
Mladjen Veselinovic ◽  
Susanne Burger ◽  
Tamara Milovanovic ◽  
...  

Liver abscess associated with suppurative portal vein thrombosis (pylephlebitis) secondary to Fusobacterium necrophorum has been rarely reported. It is considered to be an abdominal variant of Lemierre’s syndrome associated with significant morbidity and mortality. We report a case of 69-year-old man who developed liver abscess and pylephlebitis due to F. necrophorum with an unclear source of infection. We discuss the pathogenesis, diagnosis, and treatment strategy for this entity, with a review of previously published cases of pyelephlebitis due to F. necrophorum in regard to their clinical presentation and outcome.


2011 ◽  
Vol 34 (5) ◽  
pp. 431-437 ◽  
Author(s):  
Eiji YAMAMOTO ◽  
Tomoaki FUKAE ◽  
Yasufumi KAWAI ◽  
Manabu KAMIO ◽  
Hideki HONDA ◽  
...  

Apmis ◽  
1993 ◽  
Vol 101 (7-12) ◽  
pp. 904-906 ◽  
Author(s):  
LENA HAGELSKAER ◽  
GITTE PEDERSEN

Sign in / Sign up

Export Citation Format

Share Document