Surgical Ligation of Patent Ductus Arteriosus with Severe Pulmonary Hypertension in Three Dogs

Objective: To determine different treatment options in patients of Patent Ductus Arteriosus with pulmonary hypertension beyond neonatal period. Study Design: Descriptive cross sectional study. Place and Duration of Study: This study was carried out in Pediatric Cardiology department of Rawalpindi Institute of Cardiology, from Jan 2017 to Jan 2019. Methodology: Patients having PDA with pulmonary hypertension were included in the study. Treatment options were divided into percutaneous catheter device closure, surgical ligation of patent ductus arteriosus and palliative treatment. Any adverse event during the procedure was documented. Stratification was done in regard to gender and age group. Post stratification chi square test was applied and p-value less than or equal to 0.05 was considered as significant. Results: Total number of patients included in the study were 37. Mean age (years) of patients (Mean ± SD) was 19.21 ± 8.76. Mean ± SD pulmonary artery pressure was 56.43 ± 11.55 mmHg. Percutaneous catheter device closure was successful in 24 (64.9%) patients, in 7 (18.9%) patients primary surgical PDA ligation was done, 3 (8.1%) patients were advised palliative treatment and in 3 (8.1%) patients adverse events occurred during percutaneous device closure and were thus referred for surgical ligation. Patent ductus Arteriosus Occlutech device was used in 18 (48.6%) patients, Occlutech VSD device was used in 7 (18.5%) patients and in 1 (2.7%) patient AGA duct occluder was used. Conclusion: In patients with patent ductus arteriosus and pulmonary artery hypertension, percutaneous catheter device closure is a safe and effective procedure.

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MODERATE TO SEVERE PULMONARY HYPERTENSION ACCOMPANYING PATENT DUCTUS ARTERIOSUS

Heart ◽

10.1136/hrt.26.5.600 ◽

1964 ◽

Vol 26 (5) ◽

pp. 600-605 ◽

Cited By ~ 12

Author(s):

J. M. Reid ◽

J. G. Stevenson ◽

E. N. Coleman ◽

R. S. Barclay ◽

T. M. Welsh ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Patent Ductus Arteriosus ◽

Ductus Arteriosus ◽

Severe Pulmonary Hypertension ◽

Patent Ductus

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Unmasking of patent ductus arteriosus on cardiopulmonary bypass: Role of intraoperative trans-esophageal echocardiography in a patient with severe pulmonary hypertension due to pulmonary vein stenosis and cor triatriatum

Annals of Cardiac Anaesthesia ◽

10.4103/0971-9784.81573 ◽

2011 ◽

Vol 14 (2) ◽

pp. 152 ◽

Cited By ~ 1

Author(s):

Suman Kandachar ◽

Murali Chakravarthy ◽

Jayaprakash Krishnamoorthy ◽

Sharadaprasad Suryaprakash ◽

Geetha Muniappa ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Cardiopulmonary Bypass ◽

Patent Ductus Arteriosus ◽

Pulmonary Vein ◽

Ductus Arteriosus ◽

Pulmonary Vein Stenosis ◽

Severe Pulmonary Hypertension ◽

Vein Stenosis ◽

Patent Ductus

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Surgical treatment following transcatheter intervention in an adult patient with supravalvar mitral ring, large patent ductus arteriosus and severe pulmonary hypertension

International Journal of Cardiology ◽

10.1016/j.ijcard.2014.09.044 ◽

2014 ◽

Vol 177 (1) ◽

pp. 146-148

Author(s):

Dongxu Li ◽

Ke Lin ◽

Qi An ◽

Yuan Feng

Keyword(s):

Pulmonary Hypertension ◽

Surgical Treatment ◽

Patent Ductus Arteriosus ◽

Adult Patient ◽

Ductus Arteriosus ◽

Severe Pulmonary Hypertension ◽

Transcatheter Intervention ◽

Patent Ductus

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Transcatheter Closure of Adult Patent Ductus Arteriosus with Severe Pulmonary Hypertension

Hypertension Research ◽

10.1291/hypres.31.1997 ◽

2008 ◽

Vol 31 (11) ◽

pp. 1997-2002 ◽

Cited By ~ 9

Author(s):

Qiang Ji ◽

Jing Feng ◽

Yunqing Mei ◽

Xisheng Wang ◽

Jiangzhi Cai ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Patent Ductus Arteriosus ◽

Transcatheter Closure ◽

Ductus Arteriosus ◽

Severe Pulmonary Hypertension ◽

Patent Ductus

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Transcatheter intervention following ambrisentan treatment in an adult patient with patent ductus arteriosus and severe pulmonary hypertension

International Journal of Cardiology ◽

10.1016/j.ijcard.2014.03.035 ◽

2014 ◽

Vol 173 (2) ◽

pp. e16-e17 ◽

Cited By ~ 5

Author(s):

Ling Yunfei ◽

Lin Ke ◽

An Qi ◽

Feng Yuan

Keyword(s):

Pulmonary Hypertension ◽

Patent Ductus Arteriosus ◽

Adult Patient ◽

Ductus Arteriosus ◽

Severe Pulmonary Hypertension ◽

Transcatheter Intervention ◽

Patent Ductus

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ASSA13-15-6 Transcatheter Closure of Patent Ductus Arteriosus with Severe Pulmonary Hypertension Using Domestic Occluder in Adults

Heart ◽

10.1136/heartjnl-2013-303992.211 ◽

2013 ◽

Vol 99 (Suppl 1) ◽

pp. A68.3-A69

Author(s):

Han Xiumin ◽

Zhu Xianyang ◽

Zhang Duanzhen

Keyword(s):

Pulmonary Hypertension ◽

Patent Ductus Arteriosus ◽

Transcatheter Closure ◽

Ductus Arteriosus ◽

Severe Pulmonary Hypertension ◽

Patent Ductus

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Short-term results of interventional therapy for infants (7–36 months old) with patent ductus arteriosus and moderate-to-severe pulmonary hypertension: a retrospective study

Journal of Cardiothoracic Surgery ◽

10.1186/s13019-020-01110-5 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Yue Shu ◽

Yilong Guo ◽

Xiaoqi Wang ◽

Dexing Zhou

Keyword(s):

Pulmonary Hypertension ◽

Retrospective Study ◽

Patent Ductus Arteriosus ◽

Ductus Arteriosus ◽

Interventional Therapy ◽

Severe Pulmonary Hypertension ◽

Short Term ◽

Patent Ductus

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The effects of ductal size on the severity of pulmonary hypertension in children with patent ductus arteriosus (PDA): a multi-center study

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01449-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Josephat M. Chinawa ◽

Bartholomew F. Chukwu ◽

Awoere T. Chinawa ◽

Chika O. Duru

Keyword(s):

Pulmonary Hypertension ◽

Pulmonary Artery ◽

Patent Ductus Arteriosus ◽

Ductus Arteriosus ◽

Systolic Pressure ◽

Pulmonary Artery Systolic Pressure ◽

Severe Pulmonary Hypertension ◽

The Mean ◽

Hypertension In Children ◽

Patent Ductus

Abstract Introduction Patent ductus arteriosus (PDA) is a common acyanotic heart disease that presents with variable symptoms. Objectives This study is therefore aimed at determining the relationship between gender, age, and size of PDA and pulmonary hypertension. This study also seeks to determine the prevalence of elevated pulmonary artery systolic pressure in children with PDA. Patients and methods A descriptive study of children with patent ductus arteriosus was carried out from 2016 to 2020 in three institutions. The data were analysed with the IBM SPSS statistics for windows, version 20 (IBM Corp, Chicago) Result The mean ductal size was 3.78 (2.39) mm, with a minimum of 1.0 mm and a maximum size of 10.0 mm. The mean ductal size for males, 4.02 (2.53) mm was comparable with that of the females, 3.61 (2.28) mm (Student T-test = 0.8, 0.4). The mean pulmonary artery systolic pressure (PASP) of the patients was 43.36 (24.46) mmHg. Also the mean PASP was comparable among the males and the females, 48.37 (26.69) mmHg versus 39.63 (22.16) mmHg (Student T-test = 1.81, p = 0.07). There was no correlation between age and PASP (correlation coefficient = 0.009, p = 0.92). Sixty point two percent (60.2%) (62/103) of children with PDA had pulmonary hypertension. The proportion of males with pulmonary hypertension, 48.39% (30/62) was comparable with that of the females, 51.61% (32/62) (Chi2 = 2.05, p = 0.15) and females are 1.8 times more likely to have pulmonary hypertension as males (odds ratio 1.81, 95% CI 0.8–4.1). There was a positive correlation between ductal size and PASP (Pearson correlation coefficient = 0.26, p value = 0.007). Those with moderate and large sized duct tend to have moderate and severe pulmonary hypertension respectively and this is statistically significant. Chi2 = 17.85, p = 0.007 Conclusion The prevalence of pulmonary hypertension in children with PDA is 60.2%. Moderate and large size duct presents with moderate and severe pulmonary hypertension respectively. Females are 1.8 times more likely to have pulmonary hypertension than the males.

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