A new aerodynamic design strategy of the S-shaped transition duct between two compressor components was studied. Based on the controlled wall pressure gradient distribution and the wall velocity distribution, a semi-inverse problem of the transition duct was proposed, the corresponding inverse and direct approach codes were developed. To verify the feasibility of this method, two axial-centrifugal compressor transition ducts were designed. The results show that the static pressure distribution on the inner wall and the duct geometry both can be controlled freely by adjusting the inverse design parameters. The designed inner wall pressure distribution can be realized through a numerical matching procedure of the outer wall geometry based on the direct problem. The new design method is practicable that, without searching the optimal solution of the static pressure distribution of the inner wall, the total pressure coefficient can be at least 0.92.