OS1416 Evaluation of Viscoelastic Properties of Gasket Material at Elevated Temperature

2012 ◽  
Vol 2012 (0) ◽  
pp. _OS1416-1_-_OS1416-3_
Author(s):  
Naoki ISHII ◽  
Yuya MIYAZAWA ◽  
Masahiro HAGIHARA ◽  
Atsushi YAMAGUCHI ◽  
Hirokazu TSUJI
Keyword(s):  
Elevated Temperature ◽  
Viscoelastic Properties ◽  
Gasket Material

scholarly journals Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System

2019 ◽  
Vol 12 (1) ◽  
pp. 40 ◽  
Author(s):  
Justyna Knapik-Kowalczuk ◽  
Krzysztof Chmiel ◽  
Karolina Jurkiewicz ◽  
Natália Correia ◽  
Wiesław Sawicki ◽  
...  
Keyword(s):  
Elevated Temperature ◽  
Viscoelastic Properties ◽  
Room Temperature ◽  
Physical Stability ◽  
Ternary Systems ◽  
Storage Conditions ◽  
X Ray Diffraction ◽  
X Ray ◽  
Temperature Conditions ◽  
First Time

The purpose of this paper is to examine the physical stability as well as viscoelastic properties of the binary amorphous ezetimibe–simvastatin system. According to our knowledge, this is the first time that such an amorphous composition is prepared and investigated. The tendency toward re-crystallization of the amorphous ezetimibe–simvastatin system, at both standard storage and elevated temperature conditions, have been studied by means of X-ray diffraction (XRD). Our investigations have revealed that simvastatin remarkably improves the physical stability of ezetimibe, despite the fact that it works as a plasticizer. Pure amorphous ezetimibe, when stored at room temperature, begins to re-crystallize after 14 days after amorphization. On the other hand, the ezetimibe-simvastatin binary mixture (at the same storage conditions) is physically stable for at least 1 year. However, the devitrification of the binary amorphous composition was observed at elevated temperature conditions (T = 373 K). Therefore, we used a third compound to hinder the re-crystallization. Finally, both the physical stability as well as viscoelastic properties of the ternary systems containing different concentrations of the latter component have been thoroughly investigated.

scholarly journals 652 Evaluation of Viscoelastic Properties of Gasket Material by Nanoindentation Technique

2011 ◽  
Vol 2011 (0) ◽  
pp. 170-171
Author(s):  
Naoki ISHII ◽  
Masahiro HAGIHARA ◽  
Shinobu KANEDA ◽  
Hirokazu TSUJI
Keyword(s):  
Viscoelastic Properties ◽  
Nanoindentation Technique ◽  
Gasket Material
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