The treatment of status asthmaticus (epinephrine-fast state in an acutely ill asthmatic patient) has been described frequently; however, the need to correct the respiratory and metabolic acidosis which accompanies this condition has not been emphasized. Recently such recommendations have appeared in the nonpediatric literature of this country and of Europe. The purpose of this paper is to report two pediatric patients with status asthmaticus who recovered after administration of Tris (hydroxymethyl) aminomethane (THAM), an amine alkalinizing agent.
Methods
The Astrup technique employing the ME-l equipment and Sigaard-Andersen's nomogram were used to determine pH, pCO2, Base Excess (B.E.), Buffer Base (B.B.) and Standard Bicarbonate (S.B.) of capillary blood. Serum electrolytes were determined by conventional methods. [SEE TABLE I AND II IN SOURCE PDF].