scholarly journals Statin Therapy and the Risk of Osteoporotic Fractures in Patients with Metabolic Syndrome: a Nested Case-Control Study

2021 ◽  
Vol 10 (3) ◽  
pp. 322
Author(s):  
Kyoung Jin Kim ◽  
Jimi Choi ◽  
Ji Yoon Kim ◽  
Jae Hyun Bae ◽  
Kyeong Jin Kim ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Statin Therapy ◽  
Case Control Study ◽  
Osteoporotic Fractures ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Association of cystatin C levels with metabolic syndrome incidence: a nested case-control study with propensity score matching

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098631
Author(s):  
Tengfei Yang ◽  
Dongmei Pei
Keyword(s):  
Metabolic Syndrome ◽  
Propensity Score ◽  
Physical Examination ◽  
Propensity Score Matching ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Adults ◽  
Biochemical Profiles ◽  
Nested Case Control ◽  
Control Study

Objective Metabolic syndrome (MetS) involves multiple metabolic disorders and seriously affects human health. Identification of key biological factors associated with MetS incidence is therefore important. We explored the association between MetS and the biochemical profiles of Chinese adults in Shenyang City in a nested case-control study. Methods We included adult participants who underwent physical examination at our hospital for 2 consecutive years. Participants’ biochemical profiles and other MetS components were tested and monitored continuously. Propensity score matching was used to adjust confounding factors between participants with and without MetS. We analyzed the association between incidence of MetS and the biochemical profiles of participants. Results Of 5702 participants who underwent physical examination between 1 January 2017 and 1 December 2018, 538 had confirmed newly developed MetS. After successfully matching 436 pairs of participants, mean cystatin C (Cys-C) level was significantly higher in the MetS group than in the non-MetS group. Logistic regression analysis indicated that age (years) and γ-glutamate transpeptidase, creatinine, uric acid, and Cys-C levels were significantly associated with MetS incidence; among these, the odds ratio of Cys-C was highest (3.03; 95% confidence interval, 1.02–9.00). Conclusions Cys-C levels were significantly associated with the incidence of MetS among Chinese adults.

MFGE8 polymorphisms are significantly associated with metabolism-related indicators rather than metabolic syndrome in Chinese people: A nested case–control study

Gene ◽  
2018 ◽  
Vol 677 ◽  
pp. 176-181 ◽  
Author(s):  
Leilei Liu ◽  
Cheng Cheng ◽  
Dongdong Zhang ◽  
Ruiyuan Zhang ◽  
Yu Liu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Case Control Study ◽  
Case Control ◽  
Chinese People ◽  
Nested Case Control ◽  
Control Study

scholarly journals Incidence and predictors of osteoporotic fractures in patients with Barrett's oesophagus: a population-based nested case-control study

2017 ◽  
Vol 46 (11-12) ◽  
pp. 1094-1102 ◽  
Author(s):  
S. Kumar ◽  
M. T. Drake ◽  
C. D. Schleck ◽  
M. L. Johnson ◽  
J. A. Alexander ◽  
...  
Keyword(s):  
Case Control Study ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Case Control ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus ◽  
Nested Case Control ◽  
Control Study

scholarly journals Comparing proton pump inhibitors with histamin-2 receptor blockers regarding the risk of osteoporotic fractures: a nested case-control study of more than 350,000 Korean patients with GERD and peptic ulcer disease

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Joo-Hyun Park ◽  
Jessie Lee ◽  
Su-Yeon Yu ◽  
Jin-Hyung Jung ◽  
Kyungdo Han ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Proton Pump ◽  
Osteoporotic Fracture ◽  
Claims Data ◽  
Case Control Study ◽  
Osteoporotic Fractures ◽  
Case Control ◽  
Ulcer Disease ◽  
Nested Case Control ◽  
Control Study

Abstract Background Patients with peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) are more likely to receive long-term therapy with proton pump inhibitors (PPIs). This study aimed to investigate the risk of osteoporotic fractures in PPI users compared to histamine-2 receptor antagonist (H2RA) users and the association between fractures and the duration and regular use of PPI. Methods A population-based, nationwide nested case-control study from January 2006 to December 2015 was performed using Korean National Health Insurance Service claims data. We included patients ≥50 years of age, without previous fractures, newly prescribed with PPI or H2RA, and diagnosed with PUD or GERD from 2006 to 2015. Patients with osteoporotic fracture (n = 59,240) were matched with the non-fracture control group (n = 296,200) at a 1:5 ratio based on sex, age, cohort entry date, follow-up duration, and bisphosphonate use. The osteoporotic fractures were defined using the diagnostic codes of claims data (M80, M81, M82, M484, M485, S220, S221, S320, S327, S422, S423, S525, S526, S72). Results The higher the cumulative use of PPIs, the higher the osteoporotic fracture risk (P for trend < 0.001). The risk of osteoporotic fracture in the patients whose cumulative use of PPI was more than 1 year was higher than that of others (OR: 1.42, 95% CI: 1.32–1.52). Patients who regularly used PPI in the recent 1 year had a higher risk of osteoporotic fracture than exclusive H2RA users (OR: 1.37, 95% CI: 1.26–1.50). Conclusions The risk of osteoporotic fracture increased with the duration of PPI use, especially when PPI was used for ≥1 year and regularly in the recent 1 year.

scholarly journals Correction to: Acetylcholinesterase inhibitors and the risk of osteoporotic fractures: nested case-control study

2019 ◽  
Vol 30 (5) ◽  
pp. 1143-1143
Author(s):  
I. Tamimi ◽  
B. Nicolau ◽  
H. Eimar ◽  
S. Arekunnath Madathil ◽  
A. Kezouh ◽  
...  
Keyword(s):  
Case Control Study ◽  
Osteoporotic Fractures ◽  
Acetylcholinesterase Inhibitors ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document