U.S. Case Definition of Chronic Fatigue Syndrome

To the Editor.— We read with great interest the article "Chronic Fatigue in Adolescents" by Smith et al in the August 1991 issue.1 We appreciate the statement by the authors that "the CDC-recommended criteria for case definition of the chronic fatigue syndrome (CFS) were developed mainly from adult populations and may not be appropriate for children and adolescents." We have studied children suffering from unexplained fatigue, mild fever, nonexudative pharyngitis, lymphadenopathia, etc, since 1987, ie, prior to publication of CDC-recommended criteria of CFS.2

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A Constructive Debate With the CDC on the Empirical Case Definition of Chronic Fatigue Syndrome

Journal of Disability Policy Studies ◽

10.1177/1044207309359515 ◽

2010 ◽

Vol 20 (4) ◽

pp. 251-256 ◽

Cited By ~ 4

Author(s):

Leonard A. Jason ◽

Nicole Porter ◽

Molly Brown ◽

Abigail Brown ◽

Meredyth Evans

Keyword(s):

Chronic Fatigue Syndrome ◽

Chronic Fatigue ◽

Case Definition ◽

Fatigue Syndrome ◽

Definition Of

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An examination of the working case definition of chronic fatigue syndrome

The American Journal of Medicine ◽

10.1016/s0002-9343(96)90012-1 ◽

1996 ◽

Vol 100 (1) ◽

pp. 56-64 ◽

Cited By ~ 95

Author(s):

Anthony L Komaroff ◽

Laura R Fagioli ◽

Ann M Geiger ◽

Teresa H Doolittle ◽

Joshua Lee ◽

...

Keyword(s):

Chronic Fatigue Syndrome ◽

Chronic Fatigue ◽

Case Definition ◽

Fatigue Syndrome ◽

Definition Of

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Methods of applying the 1994 case definition of chronic fatigue syndrome – impact on classification and observed illness characteristics

Population Health Metrics ◽

10.1186/s12963-016-0077-1 ◽

2016 ◽

Vol 14 (1) ◽

Cited By ~ 5

Author(s):

E. R. Unger ◽

J.-M. S. Lin ◽

H. Tian ◽

B. M. Gurbaxani ◽

R. S. Boneva ◽

...

Keyword(s):

Chronic Fatigue Syndrome ◽

Chronic Fatigue ◽

Case Definition ◽

Fatigue Syndrome ◽

Definition Of

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Neuropsychological deficits in patients with chronic fatigue syndrome

Journal of the International Neuropsychological Society ◽

10.1017/s1355617704102178 ◽

2004 ◽

Vol 10 (2) ◽

pp. 278-285 ◽

Cited By ~ 33

Author(s):

KIM BUSICHIO ◽

LANA A. TIERSKY ◽

JOHN DELUCA ◽

BENJAMIN H. NATELSON

Keyword(s):

Information Processing ◽

Chronic Fatigue Syndrome ◽

Executive Functioning ◽

Chronic Fatigue ◽

Case Definition ◽

Motor Speed ◽

Neuropsychological Dysfunction ◽

Speed Of Information Processing ◽

Fatigue Syndrome ◽

Healthy Control

The degree of neuropsychological dysfunction across multiple domains was examined in individuals suffering from chronic fatigue syndrome (CFS). In this descriptive study, a similar series of neuropsychological tests was administered to a group of CFS patients and healthy participants. More specifically, CFS patients (n = 141) who met the 1994 Case Definition criteria were compared to 76 healthy control participants on tests of memory, attention (concentration), speed of information processing, motor speed, and executive functioning. On the 18 measures administered, CFS patients scored 1 standard deviation below the healthy mean on nine measures and scored 2 standard deviations below the healthy mean on four of the measures. Moreover, results indicated that CFS patients were more likely than healthy controls to fail (1.6 SD below the healthy mean) at least one test in each of the following domains: attention, speed of information processing, and motor speed, but not on measures of memory and executive functioning. Finally, CFS patients demonstrated a greater total number of tests failed across domains. (JINS, 2004, 10, 278–285.)

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