Definition of the Chronic Fatigue Syndrome

Chronic fatigue syndrome (CFS) and fibromyalgia (FM) appear to meet the criteria of a tryptophan-kynurenine pathway disorder with potential neuroimmunological sequelae. Aspects of some of the putative precipitating factors have been previously outlined. 2 , 3 An analysis of the areas of metabolic dysfunction will focus on future directions for research and management. The definition of dual tryptophan pathways has increased the understanding of the mind-body, body-mind dichotomy. The serotonergic pathway highlights the primary (endogenous) psychiatric disorders. The up-regulation of the kynurenine pathway by physical illnesses can cause neuropathic and immunological disorders 1 associated with secondary neuropsychiatric symptoms. Tryptophan and nicotinamide deficiencies fall within the protein energy malnutrition (PEM) spectrum. They can arise if the kynurenine pathway is stressed by primary or secondary inflammatory conditions and the consequent imbalance of available catabolic/anabolic substrates may adversely influence convalescent phase efficiency. The replacement of depleted or reduced NAD+ levels and other cofactors can perhaps improve the clinical management of these disorders.

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Chronic Fatigue Immune Dysfunction Syndrome: An Epidemic?

PEDIATRICS ◽

10.1542/peds.89.4.804 ◽

1992 ◽

Vol 89 (4) ◽

pp. 804-804

Author(s):

MUDR ALEŠ KMINEK ◽

MUDR IVO SIMUNEK

Keyword(s):

Chronic Fatigue Syndrome ◽

Children And Adolescents ◽

Immune Dysfunction ◽

Chronic Fatigue ◽

Case Definition ◽

Fatigue Syndrome ◽

Definition Of ◽

Mild Fever

To the Editor.— We read with great interest the article "Chronic Fatigue in Adolescents" by Smith et al in the August 1991 issue.1 We appreciate the statement by the authors that "the CDC-recommended criteria for case definition of the chronic fatigue syndrome (CFS) were developed mainly from adult populations and may not be appropriate for children and adolescents." We have studied children suffering from unexplained fatigue, mild fever, nonexudative pharyngitis, lymphadenopathia, etc, since 1987, ie, prior to publication of CDC-recommended criteria of CFS.2

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U.S. Case Definition of Chronic Fatigue Syndrome

Journal of Chronic Fatigue Syndrome ◽

10.1300/j092v05n03_02 ◽

1999 ◽

Vol 5 (3-4) ◽

pp. 3-33 ◽

Cited By ~ 24

Author(s):

Leonard A. Jason ◽

Caroline P. King ◽

Judith A. Richman ◽

Renee R. Taylor ◽

Susan R. Torres ◽

...

Keyword(s):

Chronic Fatigue Syndrome ◽

Chronic Fatigue ◽

Case Definition ◽

Fatigue Syndrome ◽

Definition Of

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Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort

Brain Sciences ◽

10.3390/brainsci11060760 ◽

2021 ◽

Vol 11 (6) ◽

pp. 760

Author(s):

J Antonio González-Hermosillo ◽

Jhanea Patricia Martínez-López ◽

Sofía Antonieta Carrillo-Lampón ◽

Dayanara Ruiz-Ojeda ◽

Sharon Herrera-Ramírez ◽

...

Keyword(s):

Chronic Fatigue Syndrome ◽

Clinical Features ◽

Length Of Hospital Stay ◽

Chronic Fatigue ◽

Median Number ◽

Myalgic Encephalomyelitis ◽

Common Symptom ◽

Fatigue Syndrome ◽

Potential Link ◽

Definition Of

The aim of this study was to describe the clinical evolution during 6 months of follow-up of adults recovered from COVID-19. We tried to determine how many met the definition of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A total of 130 patients (51.0 ± 14 years, 34.6% female) were enrolled. Symptoms were common, participants reported a median number of 9 (IQR 5–14) symptoms. Fatigue was the most common symptom (61/130; 46.9%). Patients with fatigue were older 53.9 ± 13.5 years compared with 48.5 ± 13.3 years in those without fatigue (p = 0.02) and had a longer length of hospital stay, 17 ± 14 days vs. 13 ± 10 days (p = 0.04). There was no difference in other comorbidities between patients with fatigue and those without it, and no association between COVID-19 severity and fatigue. After multivariate adjustment of all baseline clinical features, only age 40 to 50 years old was positively associated with fatigue, OR 2.5 (95% CI 1.05–6.05) p = 0.03. In our survey, only 17 (13%) patients met the Institute of Medicine’s criteria for “systemic exertion intolerance disease,” the new name of ME/CFS. In conclusion, in some patients, the features of post-acute COVID-19 syndrome overlap with the clinical features of ME/CFS.

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